Myocardial contraction is 5-fold more economical in ventricular than in atrial human tissue

Cardiac energetics and performance depend on the expression level of the fast (alpha-) and slow (beta-) myosin heavy chain (MHC) isoform. In ventricular tissue, the beta-MHC isoform predominates, whereas in atrial tissue a variable mixture of alpha- and beta-MHC is found. In several cardiac diseases...

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Veröffentlicht in:	Cardiovascular research 2005, Vol.65 (1), p.221-229
Hauptverfasser:	NAROLSKA, N. A, VAN LOON, R. B, VAN DER VELDEN, J, STIENEN, G. J. M, BOONTJE, N. M, ZAREMBA, R, EIRAS PENAS, S, RUSSELL, J, SPIEGELENBERG, S. R, HUYBREGTS, M. A. J. M, VISSER, F. C, DE JONG, J. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adult Aged Aged, 80 and over Atrial Function - physiology Biological and medical sciences Biomechanical Phenomena Cardiology. Vascular system Electrophoresis, Polyacrylamide Gel Heart Heart Atria Heart failure, cardiogenic pulmonary edema, cardiac enlargement Heart Ventricles Humans Medical sciences Middle Aged Myocardial Contraction - physiology Myocardium - metabolism Myosin Heavy Chains - metabolism Protein Isoforms - metabolism Ventricular Function - physiology
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