Role of Vasospasm in Acute Coronary Syndrome: Insights From Ergonovine Stress Echocardiography
Background Previous studies have shown that ergonovine stress echocardiography (ESE) may be a valuable noninvasive tool for the diagnosis of vasospasm after the confirmation of no significant fixed stenosis. Methods and Results From May 1999 to January 2002, 52 patients who presented with acute coro...
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| Veröffentlicht in: | Circulation Journal 2005, Vol.69(1), pp.39-43 |
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| creator | Kim, Moo Hyun Park, En Hee Yang, Doo Kyung Park, Tae Ho Kim, Sang Gon Yoon, Jin Hyuk Cha, Kwang Soo Kum, Dong Sung Kim, Hye Jin Kim, Jong Seong |
| description | Background Previous studies have shown that ergonovine stress echocardiography (ESE) may be a valuable noninvasive tool for the diagnosis of vasospasm after the confirmation of no significant fixed stenosis. Methods and Results From May 1999 to January 2002, 52 patients who presented with acute coronary syndrome (ACS) and had normal or near-normal coronary angiograms were enrolled. A 50 μg bolus of ergonovine was given intravenously at 5-min intervals, until a positive result was observed or a total dose of 350 μg was given. After the ergonovine injection, positive results were found in 25 (48%) of 52 patients: 5 (26%) of 19 with unstable angina, 10 (53%) of 19 non-ST elevation myocardial infarction (MI) and 10 (71%) of 14 patients with ST elevation MI. Using univariate analysis, the elevation of troponin concentration, clinical diagnosis of MI, and ST segment elevation on initial electrocardiographic were significantly associated with positive stress test results. Conclusions Despite the limitation that coronary spasm was not confirmed angiographically with ergonovine provocation, ESE may be a useful technique for the noninvasive diagnosis of vasospasm. (Circ J 2005; 69: 39 - 43) |
| doi_str_mv | 10.1253/circj.69.39 |
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Methods and Results From May 1999 to January 2002, 52 patients who presented with acute coronary syndrome (ACS) and had normal or near-normal coronary angiograms were enrolled. A 50 μg bolus of ergonovine was given intravenously at 5-min intervals, until a positive result was observed or a total dose of 350 μg was given. After the ergonovine injection, positive results were found in 25 (48%) of 52 patients: 5 (26%) of 19 with unstable angina, 10 (53%) of 19 non-ST elevation myocardial infarction (MI) and 10 (71%) of 14 patients with ST elevation MI. Using univariate analysis, the elevation of troponin concentration, clinical diagnosis of MI, and ST segment elevation on initial electrocardiographic were significantly associated with positive stress test results. Conclusions Despite the limitation that coronary spasm was not confirmed angiographically with ergonovine provocation, ESE may be a useful technique for the noninvasive diagnosis of vasospasm. (Circ J 2005; 69: 39 - 43)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.69.39</identifier><identifier>PMID: 15635200</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Acute coronary syndrome ; Acute Disease ; Chest Pain - epidemiology ; Coronary Disease - diagnostic imaging ; Coronary Vasospasm - diagnostic imaging ; Coronary Vasospasm - physiopathology ; Echocardiography, Stress - methods ; Ergonovine - administration & dosage ; Ergonovine stress echocardiogram ; Female ; Humans ; Hyperlipidemias - epidemiology ; Hypertension - epidemiology ; Japan ; Male ; Middle Aged ; Oxytocics - administration & dosage ; Retrospective Studies ; Risk Factors ; Smoking ; Vasospasm</subject><ispartof>Circulation Journal, 2005, Vol.69(1), pp.39-43</ispartof><rights>2005 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-db76c5fca8300966cfda2f96868e4980210fcc6aa47caf1a970516cfe228c2b03</citedby><cites>FETCH-LOGICAL-c447t-db76c5fca8300966cfda2f96868e4980210fcc6aa47caf1a970516cfe228c2b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15635200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Moo Hyun</creatorcontrib><creatorcontrib>Park, En Hee</creatorcontrib><creatorcontrib>Yang, Doo Kyung</creatorcontrib><creatorcontrib>Park, Tae Ho</creatorcontrib><creatorcontrib>Kim, Sang Gon</creatorcontrib><creatorcontrib>Yoon, Jin Hyuk</creatorcontrib><creatorcontrib>Cha, Kwang Soo</creatorcontrib><creatorcontrib>Kum, Dong Sung</creatorcontrib><creatorcontrib>Kim, Hye Jin</creatorcontrib><creatorcontrib>Kim, Jong Seong</creatorcontrib><title>Role of Vasospasm in Acute Coronary Syndrome: Insights From Ergonovine Stress Echocardiography</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background Previous studies have shown that ergonovine stress echocardiography (ESE) may be a valuable noninvasive tool for the diagnosis of vasospasm after the confirmation of no significant fixed stenosis. Methods and Results From May 1999 to January 2002, 52 patients who presented with acute coronary syndrome (ACS) and had normal or near-normal coronary angiograms were enrolled. A 50 μg bolus of ergonovine was given intravenously at 5-min intervals, until a positive result was observed or a total dose of 350 μg was given. After the ergonovine injection, positive results were found in 25 (48%) of 52 patients: 5 (26%) of 19 with unstable angina, 10 (53%) of 19 non-ST elevation myocardial infarction (MI) and 10 (71%) of 14 patients with ST elevation MI. Using univariate analysis, the elevation of troponin concentration, clinical diagnosis of MI, and ST segment elevation on initial electrocardiographic were significantly associated with positive stress test results. Conclusions Despite the limitation that coronary spasm was not confirmed angiographically with ergonovine provocation, ESE may be a useful technique for the noninvasive diagnosis of vasospasm. (Circ J 2005; 69: 39 - 43)</description><subject>Acute coronary syndrome</subject><subject>Acute Disease</subject><subject>Chest Pain - epidemiology</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Vasospasm - diagnostic imaging</subject><subject>Coronary Vasospasm - physiopathology</subject><subject>Echocardiography, Stress - methods</subject><subject>Ergonovine - administration & dosage</subject><subject>Ergonovine stress echocardiogram</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperlipidemias - epidemiology</subject><subject>Hypertension - epidemiology</subject><subject>Japan</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxytocics - administration & dosage</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Vasospasm</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0M1LwzAYBvAgipvTk3fpycvszFfT5OYYfsFA8OsasvSNdrTNTNrD_nvrOtwlb-D98fDyIHRJ8IzQjN3aMtj1TKgZU0doTBjPUy4pPt79RaokZyN0FuMaY6pwpk7RiGSCZRTjMbp59RUk3iWfJvq4MbFOyiaZ266FZOGDb0zYJm_bpgi-hnN04kwV4WI_J-jj4f598ZQuXx6fF_NlajnP27RY5cJmzhrJMFZCWFcY6pSQQgJXElOCnbXCGJ5b44hROc5Ir4BSaekKswm6HnI3wf90EFtdl9FCVZkGfBe1yBmnXNAeTgdog48xgNObUNb9yZpg_VeO3pWjhdJM9fpqH9utaigOdt9GD-4GsI6t-YJ_YEJb2goOYWR4mDqsvk3Q0LBfZMp3BA</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Kim, Moo Hyun</creator><creator>Park, En Hee</creator><creator>Yang, Doo Kyung</creator><creator>Park, Tae Ho</creator><creator>Kim, Sang Gon</creator><creator>Yoon, Jin Hyuk</creator><creator>Cha, Kwang Soo</creator><creator>Kum, Dong Sung</creator><creator>Kim, Hye Jin</creator><creator>Kim, Jong Seong</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Role of Vasospasm in Acute Coronary Syndrome</title><author>Kim, Moo Hyun ; Park, En Hee ; Yang, Doo Kyung ; Park, Tae Ho ; Kim, Sang Gon ; Yoon, Jin Hyuk ; Cha, Kwang Soo ; Kum, Dong Sung ; Kim, Hye Jin ; Kim, Jong Seong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-db76c5fca8300966cfda2f96868e4980210fcc6aa47caf1a970516cfe228c2b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acute coronary syndrome</topic><topic>Acute Disease</topic><topic>Chest Pain - epidemiology</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Vasospasm - diagnostic imaging</topic><topic>Coronary Vasospasm - physiopathology</topic><topic>Echocardiography, Stress - methods</topic><topic>Ergonovine - administration & dosage</topic><topic>Ergonovine stress echocardiogram</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperlipidemias - epidemiology</topic><topic>Hypertension - epidemiology</topic><topic>Japan</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxytocics - administration & dosage</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Vasospasm</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Moo Hyun</creatorcontrib><creatorcontrib>Park, En Hee</creatorcontrib><creatorcontrib>Yang, Doo Kyung</creatorcontrib><creatorcontrib>Park, Tae Ho</creatorcontrib><creatorcontrib>Kim, Sang Gon</creatorcontrib><creatorcontrib>Yoon, Jin Hyuk</creatorcontrib><creatorcontrib>Cha, Kwang Soo</creatorcontrib><creatorcontrib>Kum, Dong Sung</creatorcontrib><creatorcontrib>Kim, Hye Jin</creatorcontrib><creatorcontrib>Kim, Jong Seong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Moo Hyun</au><au>Park, En Hee</au><au>Yang, Doo Kyung</au><au>Park, Tae Ho</au><au>Kim, Sang Gon</au><au>Yoon, Jin Hyuk</au><au>Cha, Kwang Soo</au><au>Kum, Dong Sung</au><au>Kim, Hye Jin</au><au>Kim, Jong Seong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Vasospasm in Acute Coronary Syndrome: Insights From Ergonovine Stress Echocardiography</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2005</date><risdate>2005</risdate><volume>69</volume><issue>1</issue><spage>39</spage><epage>43</epage><pages>39-43</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background Previous studies have shown that ergonovine stress echocardiography (ESE) may be a valuable noninvasive tool for the diagnosis of vasospasm after the confirmation of no significant fixed stenosis. Methods and Results From May 1999 to January 2002, 52 patients who presented with acute coronary syndrome (ACS) and had normal or near-normal coronary angiograms were enrolled. A 50 μg bolus of ergonovine was given intravenously at 5-min intervals, until a positive result was observed or a total dose of 350 μg was given. After the ergonovine injection, positive results were found in 25 (48%) of 52 patients: 5 (26%) of 19 with unstable angina, 10 (53%) of 19 non-ST elevation myocardial infarction (MI) and 10 (71%) of 14 patients with ST elevation MI. Using univariate analysis, the elevation of troponin concentration, clinical diagnosis of MI, and ST segment elevation on initial electrocardiographic were significantly associated with positive stress test results. Conclusions Despite the limitation that coronary spasm was not confirmed angiographically with ergonovine provocation, ESE may be a useful technique for the noninvasive diagnosis of vasospasm. (Circ J 2005; 69: 39 - 43)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>15635200</pmid><doi>10.1253/circj.69.39</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute coronary syndrome Acute Disease Chest Pain - epidemiology Coronary Disease - diagnostic imaging Coronary Vasospasm - diagnostic imaging Coronary Vasospasm - physiopathology Echocardiography, Stress - methods Ergonovine - administration & dosage Ergonovine stress echocardiogram Female Humans Hyperlipidemias - epidemiology Hypertension - epidemiology Japan Male Middle Aged Oxytocics - administration & dosage Retrospective Studies Risk Factors Smoking Vasospasm |
| title | Role of Vasospasm in Acute Coronary Syndrome: Insights From Ergonovine Stress Echocardiography |
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