Correlation between inhalant allergen-specific IgE and pulmonary function in children with asthma
Sensitization to aeroallergens is associated with diminished lung function in adults. Little has been studied on the relationship between the inhalant allergen‐specific IgE and pulmonary function in asthmatic children. This study was focused on four major inhalant allergens found in Korea, including...
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| Veröffentlicht in: | Pediatric pulmonology 2005-02, Vol.39 (2), p.150-155 |
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| creator | Choi, Sung-Yon Sohn, Myung Hyun Yum, Hye-Yung Kwon, Byoung-Chul Kim, Kyu-Earn |
| description | Sensitization to aeroallergens is associated with diminished lung function in adults. Little has been studied on the relationship between the inhalant allergen‐specific IgE and pulmonary function in asthmatic children. This study was focused on four major inhalant allergens found in Korea, including Dermatophagoides pteronyssinus (Der p.), Dermatophagoides farinae (Der f.), and Alternaria‐ and German cockroach‐specific IgEs, with evaluation of pulmonary function in relation to the amount of allergens. The parents or legal guardians of participants enrolled in this study gave informed consent. Fifty‐five asthmatic patients and 48 nonasthmatic children were included. The amounts of specific IgE for the four specified inhalant allergens were determined by employing the CAP system FEIA. Forced expiratory volume in 1 sec (FEV1)/forced vital capacity (FVC), FEV1, and forced expiratory flow between 25% and 75% of FVC (FEF25–75) of subjects were evaluated through pulmonary function tests. In the asthmatic group, FEV1, FEV1/FVC, and FEF25–75 were significantly reduced (P |
| doi_str_mv | 10.1002/ppul.20163 |
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Little has been studied on the relationship between the inhalant allergen‐specific IgE and pulmonary function in asthmatic children. This study was focused on four major inhalant allergens found in Korea, including Dermatophagoides pteronyssinus (Der p.), Dermatophagoides farinae (Der f.), and Alternaria‐ and German cockroach‐specific IgEs, with evaluation of pulmonary function in relation to the amount of allergens. The parents or legal guardians of participants enrolled in this study gave informed consent. Fifty‐five asthmatic patients and 48 nonasthmatic children were included. The amounts of specific IgE for the four specified inhalant allergens were determined by employing the CAP system FEIA. Forced expiratory volume in 1 sec (FEV1)/forced vital capacity (FVC), FEV1, and forced expiratory flow between 25% and 75% of FVC (FEF25–75) of subjects were evaluated through pulmonary function tests. In the asthmatic group, FEV1, FEV1/FVC, and FEF25–75 were significantly reduced (P < 0.05): reduction in FEV1 (r = −0.44) and FEF25–75 (r = −0.33) in association with the Der f.‐specific allergen, and reduction in FEV1 (r = −0.37) and FEF25–75 (r = −0.34) in association with the Der p.‐specific allergen, were observed. However, there was no significant correlation with German cockroach and Alternaria allergen. In the control group, no significant correlation was detectable between the allergen‐specific IgE titers and the results of pulmonary function tests. In asthmatic patients, Der p.‐ and Der f.‐specific IgEs, and not German cockroach and Alternaria, seem to play a considerable role in reduced pulmonary function among asthmatic children. Pediatr Pulmonol. 2005;39:150–155. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.20163</identifier><identifier>PMID: 15633201</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Administration, Inhalation ; Adolescent ; Allergens - administration & dosage ; asthma ; Asthma - diagnosis ; Asthma - immunology ; Asthma - physiopathology ; Biological and medical sciences ; Bronchial Provocation Tests ; Child ; Chronic obstructive pulmonary disease, asthma ; Female ; Forced Expiratory Flow Rates - drug effects ; Forced Expiratory Flow Rates - physiology ; house dust mite ; Humans ; Immunoglobulin E - administration & dosage ; inhalant allergen ; Korea ; Male ; Medical sciences ; Pneumology ; pulmonary function test ; Pulmonary Ventilation - drug effects ; Pulmonary Ventilation - physiology ; Pyroglyphidae - immunology ; Retrospective Studies ; Severity of Illness Index ; specific IgE ; Spirometry ; Vital Capacity - drug effects ; Vital Capacity - physiology</subject><ispartof>Pediatric pulmonology, 2005-02, Vol.39 (2), p.150-155</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3953-6a9a75d6c0adf2b31d56e25b0a7d4b7cecf8c67af9430838a0f3c376a0464dfb3</citedby><cites>FETCH-LOGICAL-c3953-6a9a75d6c0adf2b31d56e25b0a7d4b7cecf8c67af9430838a0f3c376a0464dfb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fppul.20163$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fppul.20163$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16470218$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15633201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Sung-Yon</creatorcontrib><creatorcontrib>Sohn, Myung Hyun</creatorcontrib><creatorcontrib>Yum, Hye-Yung</creatorcontrib><creatorcontrib>Kwon, Byoung-Chul</creatorcontrib><creatorcontrib>Kim, Kyu-Earn</creatorcontrib><title>Correlation between inhalant allergen-specific IgE and pulmonary function in children with asthma</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>Sensitization to aeroallergens is associated with diminished lung function in adults. Little has been studied on the relationship between the inhalant allergen‐specific IgE and pulmonary function in asthmatic children. This study was focused on four major inhalant allergens found in Korea, including Dermatophagoides pteronyssinus (Der p.), Dermatophagoides farinae (Der f.), and Alternaria‐ and German cockroach‐specific IgEs, with evaluation of pulmonary function in relation to the amount of allergens. The parents or legal guardians of participants enrolled in this study gave informed consent. Fifty‐five asthmatic patients and 48 nonasthmatic children were included. The amounts of specific IgE for the four specified inhalant allergens were determined by employing the CAP system FEIA. Forced expiratory volume in 1 sec (FEV1)/forced vital capacity (FVC), FEV1, and forced expiratory flow between 25% and 75% of FVC (FEF25–75) of subjects were evaluated through pulmonary function tests. In the asthmatic group, FEV1, FEV1/FVC, and FEF25–75 were significantly reduced (P < 0.05): reduction in FEV1 (r = −0.44) and FEF25–75 (r = −0.33) in association with the Der f.‐specific allergen, and reduction in FEV1 (r = −0.37) and FEF25–75 (r = −0.34) in association with the Der p.‐specific allergen, were observed. However, there was no significant correlation with German cockroach and Alternaria allergen. In the control group, no significant correlation was detectable between the allergen‐specific IgE titers and the results of pulmonary function tests. In asthmatic patients, Der p.‐ and Der f.‐specific IgEs, and not German cockroach and Alternaria, seem to play a considerable role in reduced pulmonary function among asthmatic children. Pediatr Pulmonol. 2005;39:150–155. © 2005 Wiley‐Liss, Inc.</description><subject>Administration, Inhalation</subject><subject>Adolescent</subject><subject>Allergens - administration & dosage</subject><subject>asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - immunology</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Bronchial Provocation Tests</subject><subject>Child</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Female</subject><subject>Forced Expiratory Flow Rates - drug effects</subject><subject>Forced Expiratory Flow Rates - physiology</subject><subject>house dust mite</subject><subject>Humans</subject><subject>Immunoglobulin E - administration & dosage</subject><subject>inhalant allergen</subject><subject>Korea</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>pulmonary function test</subject><subject>Pulmonary Ventilation - drug effects</subject><subject>Pulmonary Ventilation - physiology</subject><subject>Pyroglyphidae - immunology</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>specific IgE</subject><subject>Spirometry</subject><subject>Vital Capacity - drug effects</subject><subject>Vital Capacity - physiology</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9v1DAUxC1ERZfChQ-AfIEDUlo7Tuz4iFb9h1ZtkSg9Wi-O3TU4TmonWvrt6-0u9MbpHd5vZjSD0AdKjikh5ck4zv64JJSzV2hBiZQFqSR_jRaNqOuCN5wdorcp_SIk_yR9gw5pzRnLigWC5RCj8TC5IeDWTBtjAnZhDR7ChMF7E-9NKNJotLNO48v7UwyhwzmyHwLER2znoJ_VLmC9dr6L2WHjpjWGNK17eIcOLPhk3u_vEbo9O_2xvChW1-eXy6-rQjNZs4KDBFF3XBPobNky2tXclHVLQHRVK7TRttFcgJUVIw1rgFimmeBAKl51tmVH6PPOd4zDw2zSpHqXtPG5iBnmpLhgFZWMZ_DLDtRxSCkaq8bo-lxFUaK2g6rtoOp50Ax_3LvObW-6F3S_YAY-7QFIGryNELRLLxyvBClpkzm64zbOm8f_RKqbm9vV3_Bip3FpMn_-aSD-3rYRtbq7Olf87Oe3UrLv6o49AfHPnn8</recordid><startdate>200502</startdate><enddate>200502</enddate><creator>Choi, Sung-Yon</creator><creator>Sohn, Myung Hyun</creator><creator>Yum, Hye-Yung</creator><creator>Kwon, Byoung-Chul</creator><creator>Kim, Kyu-Earn</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200502</creationdate><title>Correlation between inhalant allergen-specific IgE and pulmonary function in children with asthma</title><author>Choi, Sung-Yon ; Sohn, Myung Hyun ; Yum, Hye-Yung ; Kwon, Byoung-Chul ; Kim, Kyu-Earn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3953-6a9a75d6c0adf2b31d56e25b0a7d4b7cecf8c67af9430838a0f3c376a0464dfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Administration, Inhalation</topic><topic>Adolescent</topic><topic>Allergens - administration & dosage</topic><topic>asthma</topic><topic>Asthma - diagnosis</topic><topic>Asthma - immunology</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bronchial Provocation Tests</topic><topic>Child</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Female</topic><topic>Forced Expiratory Flow Rates - drug effects</topic><topic>Forced Expiratory Flow Rates - physiology</topic><topic>house dust mite</topic><topic>Humans</topic><topic>Immunoglobulin E - administration & dosage</topic><topic>inhalant allergen</topic><topic>Korea</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pneumology</topic><topic>pulmonary function test</topic><topic>Pulmonary Ventilation - drug effects</topic><topic>Pulmonary Ventilation - physiology</topic><topic>Pyroglyphidae - immunology</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>specific IgE</topic><topic>Spirometry</topic><topic>Vital Capacity - drug effects</topic><topic>Vital Capacity - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Sung-Yon</creatorcontrib><creatorcontrib>Sohn, Myung Hyun</creatorcontrib><creatorcontrib>Yum, Hye-Yung</creatorcontrib><creatorcontrib>Kwon, Byoung-Chul</creatorcontrib><creatorcontrib>Kim, Kyu-Earn</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Sung-Yon</au><au>Sohn, Myung Hyun</au><au>Yum, Hye-Yung</au><au>Kwon, Byoung-Chul</au><au>Kim, Kyu-Earn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between inhalant allergen-specific IgE and pulmonary function in children with asthma</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2005-02</date><risdate>2005</risdate><volume>39</volume><issue>2</issue><spage>150</spage><epage>155</epage><pages>150-155</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>Sensitization to aeroallergens is associated with diminished lung function in adults. Little has been studied on the relationship between the inhalant allergen‐specific IgE and pulmonary function in asthmatic children. This study was focused on four major inhalant allergens found in Korea, including Dermatophagoides pteronyssinus (Der p.), Dermatophagoides farinae (Der f.), and Alternaria‐ and German cockroach‐specific IgEs, with evaluation of pulmonary function in relation to the amount of allergens. The parents or legal guardians of participants enrolled in this study gave informed consent. Fifty‐five asthmatic patients and 48 nonasthmatic children were included. The amounts of specific IgE for the four specified inhalant allergens were determined by employing the CAP system FEIA. Forced expiratory volume in 1 sec (FEV1)/forced vital capacity (FVC), FEV1, and forced expiratory flow between 25% and 75% of FVC (FEF25–75) of subjects were evaluated through pulmonary function tests. In the asthmatic group, FEV1, FEV1/FVC, and FEF25–75 were significantly reduced (P < 0.05): reduction in FEV1 (r = −0.44) and FEF25–75 (r = −0.33) in association with the Der f.‐specific allergen, and reduction in FEV1 (r = −0.37) and FEF25–75 (r = −0.34) in association with the Der p.‐specific allergen, were observed. However, there was no significant correlation with German cockroach and Alternaria allergen. In the control group, no significant correlation was detectable between the allergen‐specific IgE titers and the results of pulmonary function tests. In asthmatic patients, Der p.‐ and Der f.‐specific IgEs, and not German cockroach and Alternaria, seem to play a considerable role in reduced pulmonary function among asthmatic children. Pediatr Pulmonol. 2005;39:150–155. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15633201</pmid><doi>10.1002/ppul.20163</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Inhalation Adolescent Allergens - administration & dosage asthma Asthma - diagnosis Asthma - immunology Asthma - physiopathology Biological and medical sciences Bronchial Provocation Tests Child Chronic obstructive pulmonary disease, asthma Female Forced Expiratory Flow Rates - drug effects Forced Expiratory Flow Rates - physiology house dust mite Humans Immunoglobulin E - administration & dosage inhalant allergen Korea Male Medical sciences Pneumology pulmonary function test Pulmonary Ventilation - drug effects Pulmonary Ventilation - physiology Pyroglyphidae - immunology Retrospective Studies Severity of Illness Index specific IgE Spirometry Vital Capacity - drug effects Vital Capacity - physiology |
| title | Correlation between inhalant allergen-specific IgE and pulmonary function in children with asthma |
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