Redox modulation of human prostate carcinoma cells by selenite increases radiation-induced cell killing

Although selenium compounds have been extensively studied as chemopreventative agents for prostate cancer, little is known about the potential use of selenium compounds for chemotherapy. We have shown that selenite inhibits cell growth and induces apoptosis in androgen-dependent LAPC-4 prostate canc...

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Veröffentlicht in:	Free radical biology & medicine 2005, Vol.38 (1), p.50-57
Hauptverfasser:	Husbeck, Bryan, Peehl, Donna M., Knox, Susan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - radiation effects Bcl-2 bcl-2-Associated X Protein Free radicals Gamma Rays Glutathione - analysis GSH Humans Male Oxidation-Reduction Prostate - drug effects Prostate - metabolism Prostate - radiation effects Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology Prostatic Neoplasms - radiotherapy Proto-Oncogene Proteins c-bcl-2 - metabolism Radiation therapy Radiation Tolerance Selenite Sodium Selenite - pharmacology Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - radiation effects
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