Evolving concepts on the pathogenic mechanisms of aniridia related keratopathy

Heterozygosity for PAX6 deficiency (PAX6 +/−) results in aniridia. Corneal changes in aniridia-related keratopathy (ARK) include corneal vascular pannus formation, conjunctival invasion of the corneal surface, corneal epithelial erosions and epithelial abnormalities, which eventually result in corne...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2005-03, Vol.37 (3), p.547-557
Hauptverfasser:	Ramaesh, K., Ramaesh, T., Dutton, G.N., Dhillon, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aniridia Aniridia - etiology Aniridia - genetics Aniridia - pathology Cornea - growth & development Corneal Diseases - etiology Corneal Diseases - genetics Corneal Diseases - pathology Disease Models, Animal Eye Proteins Homeodomain Proteins Humans Keratopathy Limbus Corneae - pathology Mice Mice, Knockout Models, Biological Paired Box Transcription Factors PAX6 PAX6 Transcription Factor Repressor Proteins Stem Cells - physiology
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