Physical activity in the Prevention of type 2 Diabetes: The Finnish Diabetes Prevention study
Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2005, Vol.54 (1), p.158-165 |
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| creator | LAAKSONEN, David E LINDSTRÖM, Jaana ILANNE-PARIKKA, Pirjo LOUHERANTA, Anne HÄMÄLÄINEN, Helena RASTAS, Merja SALMINEN, Virpi CEPAITIS, Zygimantas HAKUMÄKI, Martti KAIKKONEN, Hannu HÄRKÖNEN, Pirjo SUNDVALL, Jouko LAKKA, Timo A TUOMILEHTO, Jaakko UUSITUPA, Matti ERIKSSON, Johan G NISKANEN, Leo WIKSTRÖM, Katja AUNOLA, Sirkka KEINÄNEN-KIUKAANNIEMI, Sirkka LAAKSO, Mauri VALLE, Timo T |
| description | Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance who had completed 12-month LTPA questionnaires. The subjects were participants in the Finnish Diabetes Prevention Study, a randomized controlled trial of lifestyle changes including diet, weight loss, and LTPA. There were 107 new cases of diabetes during the 4.1-year follow-up period. Individuals who increased moderate-to-vigorous LTPA or strenuous, structured LTPA the most were 63-65% less likely to develop diabetes. Adjustment for changes in diet and body weight during the study attenuated the association somewhat (upper versus lower third: moderate-to-vigorous LTPA, relative risk 0.51, 95% CI 0.26-0.97; strenuous, structured LTPA, 0.63, 0.35-1.13). Low-intensity and lifestyle LTPA and walking also conferred benefits, consistent with the finding that the change in total LTPA (upper versus lower third: 0.34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals. |
| doi_str_mv | 10.2337/diabetes.54.1.158 |
| format | Article |
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We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance who had completed 12-month LTPA questionnaires. The subjects were participants in the Finnish Diabetes Prevention Study, a randomized controlled trial of lifestyle changes including diet, weight loss, and LTPA. There were 107 new cases of diabetes during the 4.1-year follow-up period. Individuals who increased moderate-to-vigorous LTPA or strenuous, structured LTPA the most were 63-65% less likely to develop diabetes. Adjustment for changes in diet and body weight during the study attenuated the association somewhat (upper versus lower third: moderate-to-vigorous LTPA, relative risk 0.51, 95% CI 0.26-0.97; strenuous, structured LTPA, 0.63, 0.35-1.13). Low-intensity and lifestyle LTPA and walking also conferred benefits, consistent with the finding that the change in total LTPA (upper versus lower third: 0.34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/diabetes.54.1.158</identifier><identifier>PMID: 15616024</identifier><identifier>CODEN: DIAEAZ</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Aerobic exercises ; Biological and medical sciences ; Diabetes Mellitus, Type 2 - prevention & control ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Energy Intake ; Exercise ; Female ; Finland ; Glucose Tolerance Test ; Health aspects ; Humans ; Leisure Activities ; Life Style ; Male ; Medical sciences ; Middle Aged ; Physical Fitness ; Prevention ; Risk Factors ; Type 2 diabetes ; Walking ; Weight Loss</subject><ispartof>Diabetes (New York, N.Y.), 2005, Vol.54 (1), p.158-165</ispartof><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 American Diabetes Association</rights><rights>Copyright American Diabetes Association Jan 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,4026,27930,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16483491$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15616024$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LAAKSONEN, David E</creatorcontrib><creatorcontrib>LINDSTRÖM, Jaana</creatorcontrib><creatorcontrib>ILANNE-PARIKKA, Pirjo</creatorcontrib><creatorcontrib>LOUHERANTA, Anne</creatorcontrib><creatorcontrib>HÄMÄLÄINEN, Helena</creatorcontrib><creatorcontrib>RASTAS, Merja</creatorcontrib><creatorcontrib>SALMINEN, Virpi</creatorcontrib><creatorcontrib>CEPAITIS, Zygimantas</creatorcontrib><creatorcontrib>HAKUMÄKI, Martti</creatorcontrib><creatorcontrib>KAIKKONEN, Hannu</creatorcontrib><creatorcontrib>HÄRKÖNEN, Pirjo</creatorcontrib><creatorcontrib>SUNDVALL, Jouko</creatorcontrib><creatorcontrib>LAKKA, Timo A</creatorcontrib><creatorcontrib>TUOMILEHTO, Jaakko</creatorcontrib><creatorcontrib>UUSITUPA, Matti</creatorcontrib><creatorcontrib>ERIKSSON, Johan G</creatorcontrib><creatorcontrib>NISKANEN, Leo</creatorcontrib><creatorcontrib>WIKSTRÖM, Katja</creatorcontrib><creatorcontrib>AUNOLA, Sirkka</creatorcontrib><creatorcontrib>KEINÄNEN-KIUKAANNIEMI, Sirkka</creatorcontrib><creatorcontrib>LAAKSO, Mauri</creatorcontrib><creatorcontrib>VALLE, Timo T</creatorcontrib><creatorcontrib>Finnish diabetes prevention study</creatorcontrib><title>Physical activity in the Prevention of type 2 Diabetes: The Finnish Diabetes Prevention study</title><title>Diabetes (New York, N.Y.)</title><addtitle>Diabetes</addtitle><description>Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance who had completed 12-month LTPA questionnaires. The subjects were participants in the Finnish Diabetes Prevention Study, a randomized controlled trial of lifestyle changes including diet, weight loss, and LTPA. There were 107 new cases of diabetes during the 4.1-year follow-up period. Individuals who increased moderate-to-vigorous LTPA or strenuous, structured LTPA the most were 63-65% less likely to develop diabetes. Adjustment for changes in diet and body weight during the study attenuated the association somewhat (upper versus lower third: moderate-to-vigorous LTPA, relative risk 0.51, 95% CI 0.26-0.97; strenuous, structured LTPA, 0.63, 0.35-1.13). Low-intensity and lifestyle LTPA and walking also conferred benefits, consistent with the finding that the change in total LTPA (upper versus lower third: 0.34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals.</description><subject>Aerobic exercises</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 2 - prevention & control</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Energy Intake</subject><subject>Exercise</subject><subject>Female</subject><subject>Finland</subject><subject>Glucose Tolerance Test</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Leisure Activities</subject><subject>Life Style</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Physical Fitness</subject><subject>Prevention</subject><subject>Risk Factors</subject><subject>Type 2 diabetes</subject><subject>Walking</subject><subject>Weight Loss</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0t2L1DAQAPAgireu_gG-SFEUfGjN5Kutb8eedwoLdw8n-CIlm067Obrp2qSH_e8vcvVjZVHyEAi_mUwmQ8hzoBnjPH9XW73BgD6TIoMMZPGALKDkZcpZ_uUhWVAKLIW8zE_IE-9vKKUqrsfkBKQCRZlYkK9X28lbo7tEm2BvbZgS65KwxeRqwFt0wfYu6ZskTHtMWHI23_g-uY7k3Dpn_fbX6Z8xPoz19JQ8anTn8dm8L8nn8w_Xq4_p-vLi0-p0nbYiFyFViheFoUbqsoxlNbThNZXKgAauNlJCrlFtBBOaGlYLiTovmNSC1xJMbARfkjf3efdD_21EH6qd9Qa7TjvsR1-pnAvg4v8QSgGSUxrhy7_gTT8OLj6iYqBiJhkbvSSv7lGrO6ysa_owaPMjY3UKrMiBxdKjSo-oFh0OuusdNjYeH_jsiI-rxp01RwPeHgREE_B7aPXofVVcrP9VzGxN33XYYhV_ZXV56F_MfRg3O6yr_WB3epiqnxMUwesZaB_HqBm0M9b_dkoUXJTA7wC6m9AX</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>LAAKSONEN, David E</creator><creator>LINDSTRÖM, Jaana</creator><creator>ILANNE-PARIKKA, Pirjo</creator><creator>LOUHERANTA, Anne</creator><creator>HÄMÄLÄINEN, Helena</creator><creator>RASTAS, Merja</creator><creator>SALMINEN, Virpi</creator><creator>CEPAITIS, Zygimantas</creator><creator>HAKUMÄKI, Martti</creator><creator>KAIKKONEN, Hannu</creator><creator>HÄRKÖNEN, Pirjo</creator><creator>SUNDVALL, Jouko</creator><creator>LAKKA, Timo A</creator><creator>TUOMILEHTO, Jaakko</creator><creator>UUSITUPA, Matti</creator><creator>ERIKSSON, Johan G</creator><creator>NISKANEN, Leo</creator><creator>WIKSTRÖM, Katja</creator><creator>AUNOLA, Sirkka</creator><creator>KEINÄNEN-KIUKAANNIEMI, Sirkka</creator><creator>LAAKSO, Mauri</creator><creator>VALLE, Timo T</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>8GL</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>2005</creationdate><title>Physical activity in the Prevention of type 2 Diabetes: The Finnish Diabetes Prevention study</title><author>LAAKSONEN, David E ; LINDSTRÖM, Jaana ; ILANNE-PARIKKA, Pirjo ; LOUHERANTA, Anne ; HÄMÄLÄINEN, Helena ; RASTAS, Merja ; SALMINEN, Virpi ; CEPAITIS, Zygimantas ; HAKUMÄKI, Martti ; KAIKKONEN, Hannu ; HÄRKÖNEN, Pirjo ; SUNDVALL, Jouko ; LAKKA, Timo A ; TUOMILEHTO, Jaakko ; UUSITUPA, Matti ; ERIKSSON, Johan G ; NISKANEN, Leo ; WIKSTRÖM, Katja ; AUNOLA, Sirkka ; KEINÄNEN-KIUKAANNIEMI, Sirkka ; LAAKSO, Mauri ; VALLE, Timo T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g474t-66388c0c5a99602f0f3d056c1a136b5517ae6b424a0c2d45ea7825a43d51c3373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aerobic exercises</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 2 - prevention & control</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. 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Academic</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LAAKSONEN, David E</au><au>LINDSTRÖM, Jaana</au><au>ILANNE-PARIKKA, Pirjo</au><au>LOUHERANTA, Anne</au><au>HÄMÄLÄINEN, Helena</au><au>RASTAS, Merja</au><au>SALMINEN, Virpi</au><au>CEPAITIS, Zygimantas</au><au>HAKUMÄKI, Martti</au><au>KAIKKONEN, Hannu</au><au>HÄRKÖNEN, Pirjo</au><au>SUNDVALL, Jouko</au><au>LAKKA, Timo A</au><au>TUOMILEHTO, Jaakko</au><au>UUSITUPA, Matti</au><au>ERIKSSON, Johan G</au><au>NISKANEN, Leo</au><au>WIKSTRÖM, Katja</au><au>AUNOLA, Sirkka</au><au>KEINÄNEN-KIUKAANNIEMI, Sirkka</au><au>LAAKSO, Mauri</au><au>VALLE, Timo T</au><aucorp>Finnish diabetes prevention study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical activity in the Prevention of type 2 Diabetes: The Finnish Diabetes Prevention study</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><addtitle>Diabetes</addtitle><date>2005</date><risdate>2005</risdate><volume>54</volume><issue>1</issue><spage>158</spage><epage>165</epage><pages>158-165</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><coden>DIAEAZ</coden><abstract>Clinical trials have demonstrated that lifestyle changes can prevent type 2 diabetes, but the importance of leisure-time physical activity (LTPA) is still unclear. We carried out post hoc analyses on the role of LTPA in preventing type 2 diabetes in 487 men and women with impaired glucose tolerance who had completed 12-month LTPA questionnaires. The subjects were participants in the Finnish Diabetes Prevention Study, a randomized controlled trial of lifestyle changes including diet, weight loss, and LTPA. There were 107 new cases of diabetes during the 4.1-year follow-up period. Individuals who increased moderate-to-vigorous LTPA or strenuous, structured LTPA the most were 63-65% less likely to develop diabetes. Adjustment for changes in diet and body weight during the study attenuated the association somewhat (upper versus lower third: moderate-to-vigorous LTPA, relative risk 0.51, 95% CI 0.26-0.97; strenuous, structured LTPA, 0.63, 0.35-1.13). Low-intensity and lifestyle LTPA and walking also conferred benefits, consistent with the finding that the change in total LTPA (upper versus lower third: 0.34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>15616024</pmid><doi>10.2337/diabetes.54.1.158</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0012-1797 |
| ispartof | Diabetes (New York, N.Y.), 2005, Vol.54 (1), p.158-165 |
| issn | 0012-1797 1939-327X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67341347 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aerobic exercises Biological and medical sciences Diabetes Mellitus, Type 2 - prevention & control Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy Intake Exercise Female Finland Glucose Tolerance Test Health aspects Humans Leisure Activities Life Style Male Medical sciences Middle Aged Physical Fitness Prevention Risk Factors Type 2 diabetes Walking Weight Loss |
| title | Physical activity in the Prevention of type 2 Diabetes: The Finnish Diabetes Prevention study |
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