Acute exposure to a novel object during consolidation enhances cognition
Environmental enrichment enhances learning and memory in both rodents and man. We examined the effect of active manipulation of a novel object (toy) on cognitive performance and acetylcholine (ACh) efflux in the hippocampus of rats. Animals exposed to the toy showed a significant increase in hippoca...
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| Veröffentlicht in: | Neuroreport 2005-01, Vol.16 (1), p.63-67 |
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| creator | Degroot, Aldemar Wolff, Mary C Nomikos, George G |
| description | Environmental enrichment enhances learning and memory in both rodents and man. We examined the effect of active manipulation of a novel object (toy) on cognitive performance and acetylcholine (ACh) efflux in the hippocampus of rats. Animals exposed to the toy showed a significant increase in hippocampal ACh efflux provided that they actively manipulated the object. Similarly, a single 1 h introduction of the novel object (toy) immediately after a training session in a radial arm maze significantly improved memory only if the animals actively manipulated the object. The data suggest that environmental enrichment during a critical period (consolidation) is sufficient to improve learning and memory. This effect is likely mediated through an enhancement of hippocampal cholinergic neurotransmission. |
| doi_str_mv | 10.1097/00001756-200501190-00015 |
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We examined the effect of active manipulation of a novel object (toy) on cognitive performance and acetylcholine (ACh) efflux in the hippocampus of rats. Animals exposed to the toy showed a significant increase in hippocampal ACh efflux provided that they actively manipulated the object. Similarly, a single 1 h introduction of the novel object (toy) immediately after a training session in a radial arm maze significantly improved memory only if the animals actively manipulated the object. The data suggest that environmental enrichment during a critical period (consolidation) is sufficient to improve learning and memory. 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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acetylcholine - metabolism Acetylcholine - physiology Animals Behavioral psychophysiology Biological and medical sciences Cognition - physiology Fundamental and applied biological sciences. Psychology Hippocampus - physiology Learning - physiology Male Maze Learning - physiology Memory - physiology Microdialysis Neurotransmission and behavior Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Touch - physiology |
| title | Acute exposure to a novel object during consolidation enhances cognition |
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