Isoflurane modulation of neuronal nicotinic acetylcholine receptors expressed in human embryonic kidney cells

It is well established that neuronal nicotinic acetylcholine receptors (nAChRs) are sensitive to inhalational anesthetics. The authors previously reported that halothane potently blocked alpha4beta2-type nAChRs of rat cortical neurons. However, the effect of isoflurane, which is widely used clinical...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2005, Vol.102 (1), p.76-84
Hauptverfasser:	YAMASHITA, Megumi, MORI, Takashi, NAGATA, Keiichi, YEH, Jay Z, NARAHASHI, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - antagonists & inhibitors Acetylcholine - pharmacology Algorithms Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation - pharmacology Biological and medical sciences Cell Line Dose-Response Relationship, Drug Electrophysiology Humans Ion Channel Gating - drug effects Isoflurane - pharmacology Kidney - metabolism Medical sciences Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques Receptors, Nicotinic - drug effects Solutions
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