Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells

In a search for new anticancer agents, we identified a novel compound polyphyllin D (PD) (diosgenyl α- l-rhamnopyranosyl-(1→2)-(α- l-arabinofuranosyl)-(1→4)]-[β- d-glucopyranoside) that induced DNA fragmentation and phosphatidyl-serine (PS) externalization in a hepatocellular carcinoma cell line Hep...

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Veröffentlicht in:	Cancer letters 2005-01, Vol.217 (2), p.203-211
Hauptverfasser:	Yuen-Nei Cheung, Jenny, Chik-Ying Ong, Rose, Suen, Yick-Keung, Ooi, Vincent, Nai-Ching Wong, Henry, Chung-Wai Mak, Thomas, Fung, Kwok-Pui, Yu, Biao, Kong, Siu-Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects Apoptosis - physiology Apoptosis Inducing Factor Blotting, Western Cancer therapies Carcinoma, Hepatocellular - metabolism Cell Line, Tumor Cytochromes c - drug effects Cytochromes c - metabolism Cytotoxicity Deoxyribonucleic acid Diosgenin - analogs & derivatives Diosgenin - pharmacology DNA Drug resistance Drug Resistance, Neoplasm Flavoproteins - drug effects Flavoproteins - metabolism Flow Cytometry HepG2 Humans Liver cancer Membrane Proteins - drug effects Membrane Proteins - metabolism Mitochondria Mitochondria - drug effects Mitochondria - pathology Molecular weight Polyphyllin D Proteins Reactive Oxygen Species - metabolism Saponins
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