Correlation between gene expression and morphological alterations in baboon carotid after balloon dilatation injury
ABSTRACT Treatment for fibroproliferative restenosis after angioplasty and endovascular surgery is an unmet medical need. Rational therapy and drug design still lack the very basic knowledge about the underlying biological processes leading to pathological changes in the vessel wall. We have develop...
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| Veröffentlicht in: | The FASEB journal 2005-01, Vol.19 (1), p.130-132 |
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| creator | Aavik, Einari Mahapatra, Ajit Boldrick, Jennifer Chen, Xin Barry, Christopher Dutoit, Daniel Sarwal, Minnie Häyry, Pekka |
| description | ABSTRACT
Treatment for fibroproliferative restenosis after angioplasty and endovascular surgery is an unmet medical need. Rational therapy and drug design still lack the very basic knowledge about the underlying biological processes leading to pathological changes in the vessel wall. We have developed a primate model for vascular response to denudation‐overstretch injury of baboon carotid artery. With this model, we have investigated the time course of vascular expression of 41,000 human cDNA clones and correlated these changes with carotid histology and function. Analysis revealed 20,788 differentially regulated cDNA clones. After high stringency data selection, the most prominently regulated 1629 cDNA clones representing 1510 genes of known function were clustered. Genes corresponding to functional and anatomical alterations in the injured carotid wall were further aligned into functional groups according to Gene Ontology classification. The observed expression patterns faithfully reflected the functional and anatomical alterations observed in the vascular wall in response to injury. The analysis presents a tentative model for genomic response to balloon catheter injury and a road map to identify time‐ related genomic alterations in human vascular specimens. |
| doi_str_mv | 10.1096/fj.04-2225fje |
| format | Article |
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Treatment for fibroproliferative restenosis after angioplasty and endovascular surgery is an unmet medical need. Rational therapy and drug design still lack the very basic knowledge about the underlying biological processes leading to pathological changes in the vessel wall. We have developed a primate model for vascular response to denudation‐overstretch injury of baboon carotid artery. With this model, we have investigated the time course of vascular expression of 41,000 human cDNA clones and correlated these changes with carotid histology and function. Analysis revealed 20,788 differentially regulated cDNA clones. After high stringency data selection, the most prominently regulated 1629 cDNA clones representing 1510 genes of known function were clustered. Genes corresponding to functional and anatomical alterations in the injured carotid wall were further aligned into functional groups according to Gene Ontology classification. The observed expression patterns faithfully reflected the functional and anatomical alterations observed in the vascular wall in response to injury. The analysis presents a tentative model for genomic response to balloon catheter injury and a road map to identify time‐ related genomic alterations in human vascular specimens.</description><identifier>ISSN: 0892-6638</identifier><identifier>EISSN: 1530-6860</identifier><identifier>DOI: 10.1096/fj.04-2225fje</identifier><identifier>PMID: 15496494</identifier><language>eng</language><publisher>United States: Federation of American Societies for Experimental Biology</publisher><subject>Animals ; balloon angioplasty ; carotid arteries ; Carotid Arteries - chemistry ; Carotid Arteries - pathology ; Carotid Artery Injuries - etiology ; Carotid Artery Injuries - genetics ; Carotid Artery Injuries - pathology ; Catheterization - adverse effects ; Catheterization - methods ; Endothelium, Vascular - chemistry ; Endothelium, Vascular - metabolism ; Endothelium, Vascular - pathology ; Gene Expression Profiling - methods ; Gene Expression Regulation - physiology ; genes ; Genes - physiology ; Male ; Microarray Analysis - methods ; Muscle, Smooth, Vascular - chemistry ; Muscle, Smooth, Vascular - metabolism ; Muscle, Smooth, Vascular - pathology ; Nucleic Acid Hybridization - methods ; Papio ursinus - genetics ; Proteins - metabolism ; Transcription, Genetic - genetics</subject><ispartof>The FASEB journal, 2005-01, Vol.19 (1), p.130-132</ispartof><rights>FASEB</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366E-1f070f593f97e47bd133c7f18f2ba37719201ace605c94e8144e7e1d422ddf403</citedby><cites>FETCH-LOGICAL-c366E-1f070f593f97e47bd133c7f18f2ba37719201ace605c94e8144e7e1d422ddf403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1096%2Ffj.04-2225fje$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1096%2Ffj.04-2225fje$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15496494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aavik, Einari</creatorcontrib><creatorcontrib>Mahapatra, Ajit</creatorcontrib><creatorcontrib>Boldrick, Jennifer</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Barry, Christopher</creatorcontrib><creatorcontrib>Dutoit, Daniel</creatorcontrib><creatorcontrib>Sarwal, Minnie</creatorcontrib><creatorcontrib>Häyry, Pekka</creatorcontrib><title>Correlation between gene expression and morphological alterations in baboon carotid after balloon dilatation injury</title><title>The FASEB journal</title><addtitle>FASEB J</addtitle><description>ABSTRACT
Treatment for fibroproliferative restenosis after angioplasty and endovascular surgery is an unmet medical need. Rational therapy and drug design still lack the very basic knowledge about the underlying biological processes leading to pathological changes in the vessel wall. We have developed a primate model for vascular response to denudation‐overstretch injury of baboon carotid artery. With this model, we have investigated the time course of vascular expression of 41,000 human cDNA clones and correlated these changes with carotid histology and function. Analysis revealed 20,788 differentially regulated cDNA clones. After high stringency data selection, the most prominently regulated 1629 cDNA clones representing 1510 genes of known function were clustered. Genes corresponding to functional and anatomical alterations in the injured carotid wall were further aligned into functional groups according to Gene Ontology classification. The observed expression patterns faithfully reflected the functional and anatomical alterations observed in the vascular wall in response to injury. The analysis presents a tentative model for genomic response to balloon catheter injury and a road map to identify time‐ related genomic alterations in human vascular specimens.</description><subject>Animals</subject><subject>balloon angioplasty</subject><subject>carotid arteries</subject><subject>Carotid Arteries - chemistry</subject><subject>Carotid Arteries - pathology</subject><subject>Carotid Artery Injuries - etiology</subject><subject>Carotid Artery Injuries - genetics</subject><subject>Carotid Artery Injuries - pathology</subject><subject>Catheterization - adverse effects</subject><subject>Catheterization - methods</subject><subject>Endothelium, Vascular - chemistry</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Endothelium, Vascular - pathology</subject><subject>Gene Expression Profiling - methods</subject><subject>Gene Expression Regulation - physiology</subject><subject>genes</subject><subject>Genes - physiology</subject><subject>Male</subject><subject>Microarray Analysis - methods</subject><subject>Muscle, Smooth, Vascular - chemistry</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Nucleic Acid Hybridization - methods</subject><subject>Papio ursinus - genetics</subject><subject>Proteins - metabolism</subject><subject>Transcription, Genetic - genetics</subject><issn>0892-6638</issn><issn>1530-6860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kL1v2zAQxYmiReM6Hbu2mrIpPX6IErs1hp02CNAhyUxQ0tGlQIsuKSPxf1-6MpCtCwk-_t473CPkE4VrCkp-tcM1iJIxVtkB35AFrTiUspHwliygUayUkjcX5ENKAwBQoPI9uaCVUFIosSBpFWJEbyYXxqLF6RlxLLY4YoEv-4gpnXQz9sUuxP3v4MPWdcYXxk8Y_5lS4bLRtCFznYlhcn1hbP7NovcntXc5fh7gxuEQj5fknTU-4cfzvSRPm_Xj6kd5_-v25-r7fdlxKdcltVCDrRS3qkZRtz3lvKstbSxrDa9rqhhQ06GEqlMCGyoE1kh7wVjfWwF8Sa7m3H0Mfw6YJr1zqUPvzYjhkLSseR6UzyUpZ7CLIaWIVu-j25l41BT0qWVtBw1Cn1vO_Odz8KHdYf9Kn2vNwLcZeHYej_9P05uHG7a5A3F6b-7W2fxlNlsTtNlGl_TTQ16VAyhFleT8L2MWlmQ</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Aavik, Einari</creator><creator>Mahapatra, Ajit</creator><creator>Boldrick, Jennifer</creator><creator>Chen, Xin</creator><creator>Barry, Christopher</creator><creator>Dutoit, Daniel</creator><creator>Sarwal, Minnie</creator><creator>Häyry, Pekka</creator><general>Federation of American Societies for Experimental Biology</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Correlation between gene expression and morphological alterations in baboon carotid after balloon dilatation injury</title><author>Aavik, Einari ; Mahapatra, Ajit ; Boldrick, Jennifer ; Chen, Xin ; Barry, Christopher ; Dutoit, Daniel ; Sarwal, Minnie ; Häyry, Pekka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366E-1f070f593f97e47bd133c7f18f2ba37719201ace605c94e8144e7e1d422ddf403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>balloon angioplasty</topic><topic>carotid arteries</topic><topic>Carotid Arteries - chemistry</topic><topic>Carotid Arteries - pathology</topic><topic>Carotid Artery Injuries - etiology</topic><topic>Carotid Artery Injuries - genetics</topic><topic>Carotid Artery Injuries - pathology</topic><topic>Catheterization - adverse effects</topic><topic>Catheterization - methods</topic><topic>Endothelium, Vascular - chemistry</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Endothelium, Vascular - pathology</topic><topic>Gene Expression Profiling - methods</topic><topic>Gene Expression Regulation - physiology</topic><topic>genes</topic><topic>Genes - physiology</topic><topic>Male</topic><topic>Microarray Analysis - methods</topic><topic>Muscle, Smooth, Vascular - chemistry</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Nucleic Acid Hybridization - methods</topic><topic>Papio ursinus - genetics</topic><topic>Proteins - metabolism</topic><topic>Transcription, Genetic - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aavik, Einari</creatorcontrib><creatorcontrib>Mahapatra, Ajit</creatorcontrib><creatorcontrib>Boldrick, Jennifer</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Barry, Christopher</creatorcontrib><creatorcontrib>Dutoit, Daniel</creatorcontrib><creatorcontrib>Sarwal, Minnie</creatorcontrib><creatorcontrib>Häyry, Pekka</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The FASEB journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aavik, Einari</au><au>Mahapatra, Ajit</au><au>Boldrick, Jennifer</au><au>Chen, Xin</au><au>Barry, Christopher</au><au>Dutoit, Daniel</au><au>Sarwal, Minnie</au><au>Häyry, Pekka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between gene expression and morphological alterations in baboon carotid after balloon dilatation injury</atitle><jtitle>The FASEB journal</jtitle><addtitle>FASEB J</addtitle><date>2005-01</date><risdate>2005</risdate><volume>19</volume><issue>1</issue><spage>130</spage><epage>132</epage><pages>130-132</pages><issn>0892-6638</issn><eissn>1530-6860</eissn><abstract>ABSTRACT
Treatment for fibroproliferative restenosis after angioplasty and endovascular surgery is an unmet medical need. Rational therapy and drug design still lack the very basic knowledge about the underlying biological processes leading to pathological changes in the vessel wall. We have developed a primate model for vascular response to denudation‐overstretch injury of baboon carotid artery. With this model, we have investigated the time course of vascular expression of 41,000 human cDNA clones and correlated these changes with carotid histology and function. Analysis revealed 20,788 differentially regulated cDNA clones. After high stringency data selection, the most prominently regulated 1629 cDNA clones representing 1510 genes of known function were clustered. Genes corresponding to functional and anatomical alterations in the injured carotid wall were further aligned into functional groups according to Gene Ontology classification. The observed expression patterns faithfully reflected the functional and anatomical alterations observed in the vascular wall in response to injury. The analysis presents a tentative model for genomic response to balloon catheter injury and a road map to identify time‐ related genomic alterations in human vascular specimens.</abstract><cop>United States</cop><pub>Federation of American Societies for Experimental Biology</pub><pmid>15496494</pmid><doi>10.1096/fj.04-2225fje</doi><tpages>3</tpages></addata></record> |
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| subjects | Animals balloon angioplasty carotid arteries Carotid Arteries - chemistry Carotid Arteries - pathology Carotid Artery Injuries - etiology Carotid Artery Injuries - genetics Carotid Artery Injuries - pathology Catheterization - adverse effects Catheterization - methods Endothelium, Vascular - chemistry Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Gene Expression Profiling - methods Gene Expression Regulation - physiology genes Genes - physiology Male Microarray Analysis - methods Muscle, Smooth, Vascular - chemistry Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Nucleic Acid Hybridization - methods Papio ursinus - genetics Proteins - metabolism Transcription, Genetic - genetics |
| title | Correlation between gene expression and morphological alterations in baboon carotid after balloon dilatation injury |
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