Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids

The gene encoding cholesterol 7alpha-hydroxylase (CYP7A1) is tightly regulated in order to control intrahepatic cholesterol and bile acid levels. Ligands of the xenobiotic-sensing pregnane X receptor inhibit CYP7A1 expression. To retrace the evolution of the molecular mechanisms underlying CYP7A1 in...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2005-02, Vol.434 (1), p.75-85
Hauptverfasser:	Handschin, Christoph, Gnerre, Carmela, Fraser, David J, Martinez-Jimenez, Celia, Jover, Ramiro, Meyer, Urs A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Acids and Salts - metabolism Bile Acids and Salts - pharmacology Cells, Cultured Chickens Cholesterol 7-alpha-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation, Enzymologic - drug effects Hepatocyte Nuclear Factor 4 Hepatocytes - drug effects Hepatocytes - metabolism Humans In Vitro Techniques Mice Mice, Knockout Molecular Sequence Data Phenobarbital - pharmacology Phosphoproteins - genetics Phosphoproteins - metabolism Receptors, Cytoplasmic and Nuclear - deficiency Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Receptors, Steroid - deficiency Receptors, Steroid - genetics Receptors, Steroid - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Species Specificity Transcription Factors - genetics Transcription Factors - metabolism
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