Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization
Aim of our study was to determine if there were distinct, disease-related patterns of urinary analytes in chronic fatigue syndrome (CFS) and chronic fatigue syndrome/fibromyalgia (CFS/FM) compared to normal controls (NC). Urine was collected from these subjects for two consecutive 24 h periods and a...
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| Veröffentlicht in: | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2005-01, Vol.814 (1), p.43-51 |
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| container_title | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences |
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| creator | Casado, Begoña Zanone, Chiara Annovazzi, Laura Iadarola, Paolo Whalen, Gail Baraniuk, James N. |
| description | Aim of our study was to determine if there were distinct, disease-related patterns of urinary analytes in chronic fatigue syndrome (CFS) and chronic fatigue syndrome/fibromyalgia (CFS/FM) compared to normal controls (NC). Urine was collected from these subjects for two consecutive 24
h periods and aliquots were submitted to micellar electrokinetic chromatography (MEKC). To compensate for the differences in peak migration times, these were normalized from the 35
min duration of run to a 100-point scale, and each peak was assigned its normalized time measure. Peak heights were also normalized by dividing the mAU by that of the internal standard (creatinine) and multiplying by 100. MEKC with normalization for peak height and migration time generated comparable results within each of the patient groups. CFS/FM and CFS had significant differences in peaks compared to NC that may be of significance as biomarkers of illnesses. |
| doi_str_mv | 10.1016/j.jchromb.2004.09.056 |
| format | Article |
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h periods and aliquots were submitted to micellar electrokinetic chromatography (MEKC). To compensate for the differences in peak migration times, these were normalized from the 35
min duration of run to a 100-point scale, and each peak was assigned its normalized time measure. Peak heights were also normalized by dividing the mAU by that of the internal standard (creatinine) and multiplying by 100. MEKC with normalization for peak height and migration time generated comparable results within each of the patient groups. CFS/FM and CFS had significant differences in peaks compared to NC that may be of significance as biomarkers of illnesses.</description><identifier>ISSN: 1570-0232</identifier><identifier>EISSN: 1873-376X</identifier><identifier>DOI: 10.1016/j.jchromb.2004.09.056</identifier><identifier>PMID: 15607706</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Chromatography, Micellar Electrokinetic Capillary - methods ; Chronic fatigue syndrome ; Creatinine - urine ; Fatigue Syndrome, Chronic - urine ; Fibromyalgia ; Fibromyalgia - urine ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Humans ; Medical sciences ; Pharmacology. Drug treatments ; Pilot Projects ; Reference Standards ; Spectrophotometry, Ultraviolet</subject><ispartof>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-01, Vol.814 (1), p.43-51</ispartof><rights>2004 Elsevier B.V.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-9c45a2ed1c78e21d369f15c8ce102f1b583863080f1e57af953ae66d04cdea6f3</citedby><cites>FETCH-LOGICAL-c422t-9c45a2ed1c78e21d369f15c8ce102f1b583863080f1e57af953ae66d04cdea6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jchromb.2004.09.056$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16370993$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15607706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Casado, Begoña</creatorcontrib><creatorcontrib>Zanone, Chiara</creatorcontrib><creatorcontrib>Annovazzi, Laura</creatorcontrib><creatorcontrib>Iadarola, Paolo</creatorcontrib><creatorcontrib>Whalen, Gail</creatorcontrib><creatorcontrib>Baraniuk, James N.</creatorcontrib><title>Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization</title><title>Journal of chromatography. B, Analytical technologies in the biomedical and life sciences</title><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><description>Aim of our study was to determine if there were distinct, disease-related patterns of urinary analytes in chronic fatigue syndrome (CFS) and chronic fatigue syndrome/fibromyalgia (CFS/FM) compared to normal controls (NC). Urine was collected from these subjects for two consecutive 24
h periods and aliquots were submitted to micellar electrokinetic chromatography (MEKC). To compensate for the differences in peak migration times, these were normalized from the 35
min duration of run to a 100-point scale, and each peak was assigned its normalized time measure. Peak heights were also normalized by dividing the mAU by that of the internal standard (creatinine) and multiplying by 100. MEKC with normalization for peak height and migration time generated comparable results within each of the patient groups. CFS/FM and CFS had significant differences in peaks compared to NC that may be of significance as biomarkers of illnesses.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Micellar Electrokinetic Capillary - methods</subject><subject>Chronic fatigue syndrome</subject><subject>Creatinine - urine</subject><subject>Fatigue Syndrome, Chronic - urine</subject><subject>Fibromyalgia</subject><subject>Fibromyalgia - urine</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Pilot Projects</subject><subject>Reference Standards</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>1570-0232</issn><issn>1873-376X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc-KFDEQxhtR3D_6CEoueuveSqeTdHsRWVwVFry44C1kkspMhu5kTLoXxsfxSc0wDXsST1VU_Spfpb6qekOhoUDFzb7Zm12K06ZpAboGhga4eFZd0l6ymknx83nJuYQaWtZeVFc57wGoBMleVheUC5ASxGX15yH5oNOR4IhmTvGwiwlnb8ghRedHzMQVEXKSCqXq9Oy3C5J8DLbUkehg_9m8cX5T4lGPW6_JoXQxzPkDKbkf40zyvNgjcTERbXYeH33YknmHPpEQ06RH_7uMxPCqeuH0mPH1Gq-rh7vPP26_1vffv3y7_XRfm65t53owHdctWmpkjy21TAyOctMbpNA6uuE96wWDHhxFLrUbONMohIXOWNTCsevq_fnd8vVfC-ZZTT4bHEcdMC5ZCckY5x0tID-DJsWcEzp1SH4qR1QU1MkctVerOepkjoJBFXPK3NtVYNlMaJ-mVjcK8G4FdDZ6dEkH4_MTJ5iEYWCF-3jmsJzj0WNS2ZTbGrQ-FReVjf4_q_wFqBW1yg</recordid><startdate>20050105</startdate><enddate>20050105</enddate><creator>Casado, Begoña</creator><creator>Zanone, Chiara</creator><creator>Annovazzi, Laura</creator><creator>Iadarola, Paolo</creator><creator>Whalen, Gail</creator><creator>Baraniuk, James N.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050105</creationdate><title>Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization</title><author>Casado, Begoña ; Zanone, Chiara ; Annovazzi, Laura ; Iadarola, Paolo ; Whalen, Gail ; Baraniuk, James N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-9c45a2ed1c78e21d369f15c8ce102f1b583863080f1e57af953ae66d04cdea6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Micellar Electrokinetic Capillary - methods</topic><topic>Chronic fatigue syndrome</topic><topic>Creatinine - urine</topic><topic>Fatigue Syndrome, Chronic - urine</topic><topic>Fibromyalgia</topic><topic>Fibromyalgia - urine</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Pilot Projects</topic><topic>Reference Standards</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Casado, Begoña</creatorcontrib><creatorcontrib>Zanone, Chiara</creatorcontrib><creatorcontrib>Annovazzi, Laura</creatorcontrib><creatorcontrib>Iadarola, Paolo</creatorcontrib><creatorcontrib>Whalen, Gail</creatorcontrib><creatorcontrib>Baraniuk, James N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chromatography. 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B, Analytical technologies in the biomedical and life sciences</jtitle><addtitle>J Chromatogr B Analyt Technol Biomed Life Sci</addtitle><date>2005-01-05</date><risdate>2005</risdate><volume>814</volume><issue>1</issue><spage>43</spage><epage>51</epage><pages>43-51</pages><issn>1570-0232</issn><eissn>1873-376X</eissn><abstract>Aim of our study was to determine if there were distinct, disease-related patterns of urinary analytes in chronic fatigue syndrome (CFS) and chronic fatigue syndrome/fibromyalgia (CFS/FM) compared to normal controls (NC). Urine was collected from these subjects for two consecutive 24
h periods and aliquots were submitted to micellar electrokinetic chromatography (MEKC). To compensate for the differences in peak migration times, these were normalized from the 35
min duration of run to a 100-point scale, and each peak was assigned its normalized time measure. Peak heights were also normalized by dividing the mAU by that of the internal standard (creatinine) and multiplying by 100. MEKC with normalization for peak height and migration time generated comparable results within each of the patient groups. CFS/FM and CFS had significant differences in peaks compared to NC that may be of significance as biomarkers of illnesses.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15607706</pmid><doi>10.1016/j.jchromb.2004.09.056</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-01, Vol.814 (1), p.43-51 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, Micellar Electrokinetic Capillary - methods Chronic fatigue syndrome Creatinine - urine Fatigue Syndrome, Chronic - urine Fibromyalgia Fibromyalgia - urine Fundamental and applied biological sciences. Psychology General pharmacology Humans Medical sciences Pharmacology. Drug treatments Pilot Projects Reference Standards Spectrophotometry, Ultraviolet |
| title | Urinary electrophoretic profiles from chronic fatigue syndrome and chronic fatigue syndrome/fibromyalgia patients: a pilot study for achieving their normalization |
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