Leishmania lipophosphoglycan activates the transcription factor activating protein 1 in J774A.1 macrophages through the extracellular signal-related kinase (ERK) and p38 mitogen-activated protein kinase

Leishmania donovani is an obligatory intracellular pathogen that resides and multiplies in the phagolysosomes of macrophages. The outcome of this infection depends on the balance between the host ability to activate macrophage killing and the parasite ability to suppress or evade this host immune re...

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Veröffentlicht in:	Molecular and biochemical parasitology 2005, Vol.139 (1), p.117-127
Hauptverfasser:	Balaraman, Sridevi, Singh, Vandana K., Tewary, Poonam, Madhubala, Rentala
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AP-1 transcription factor Cell Line Cells, Cultured Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation Glycosphingolipids - immunology Interleukin-12 - biosynthesis JNK Mitogen-Activated Protein Kinases Leishmania donovani Leishmania donovani - immunology Leishmania donovani - pathogenicity Lipophosphoglycan Macrophages Macrophages - immunology Macrophages - metabolism Mice Mitogen-activated protein kinase Mitogen-Activated Protein Kinase 1 Nitric Oxide - biosynthesis p38 Mitogen-Activated Protein Kinases - metabolism Transcription Factor AP-1 - metabolism Virulence
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