Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness

ABSTRACT We recently established the critical role of the lipid phosphatase activity of the PTEN tumor suppressor in stabilizing cell‐cell contacts and suppressing invasiveness. To delineate the effector systems involved, we investigated the interaction of PTEN with E‐cadherin junctional complexes i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2005-01, Vol.19 (1), p.115-117
Hauptverfasser:	Kotelevets, Larissa, van Hengel, Jolanda, Bruyneel, Erik, Mareel, Marc, van Roy, Frans, Chastre, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Adherens Junctions - metabolism AKT protein kinase alpha Catenin Amino Acid Sequence Animals Antennapedia Homeodomain Protein Caco-2 Cells - chemistry Caco-2 Cells - metabolism Cadherins - metabolism Carcinoma - genetics Cell Line Cell Line, Tumor Cytoskeletal Proteins - metabolism Dogs E‐cadherin Genes, src Homeodomain Proteins - chemistry HT29 Cells - chemistry HT29 Cells - metabolism Humans junctional complexes Kidney - cytology Kidney - embryology Male Membrane Proteins - metabolism Molecular Sequence Data Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Nuclear Proteins - chemistry Phosphatidate Phosphatase Phosphatidylinositol 3-Kinases - metabolism Phosphoric Monoester Hydrolases - deficiency Phosphoric Monoester Hydrolases - metabolism Prostatic Neoplasms - genetics Protein-Serine-Threonine Kinases - physiology Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-akt PTEN Phosphohydrolase Signal Transduction Src Transcription Factors - chemistry Tumor Suppressor Proteins - deficiency Tumor Suppressor Proteins - metabolism β‐catenin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!