Reversal of a hallmark of brain ageing: lipofuscin accumulation

The prospect of removing cellular deposits of lipofuscin is of considerable interest because they may contribute to age related functional decline and disease. Here, we use a decapod crustacean model to circumvent a number of problems inherent in previous studies on lipofuscin loss. We employ (a) va...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neurobiology of aging 2005, Vol.26 (1), p.69-76
Hauptverfasser:	Fonseca, D.B., Sheehy, M.R.J., Blackman, N., Shelton, P.M.J., Prior, A.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycosylation end product Aging - physiology Animals Anti-ageing Antioxidant Astacoidea Biological and medical sciences Biomarkers Blood transport Brain - metabolism Brain - ultrastructure Caloric restriction Carbonyl CNS biopsy Cross-Sectional Studies Degradability Deleteriousness Development. Senescence. Regeneration. Transplantation Exocytosis Free radical Functional Laterality Fundamental and applied biological sciences. Psychology Ganglia, Invertebrate - metabolism Ganglia, Invertebrate - ultrastructure Glial uptake Hormesis In vivo Insulin receptor gene Late-life mortality decline Linear Models Lipofuscin - metabolism Longitudinal sampling Microscopy, Electron, Transmission - methods Nerve Tissue - metabolism Nerve Tissue - ultrastructure Reproducibility of Results Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!