Oxidative stress inactivates VEGF survival signaling in retinal endothelial cells via PI 3-kinase tyrosine nitration

In diabetic retinopathy, endothelial cell apoptosis is paradoxically increased despite upregulation of the potent pro-survival factor VEGF. We tested the hypothesis that elevated glucose levels disrupt VEGF's pro-survival function via peroxynitrite-mediated alteration of the Akt-1/p38 MAP kinas...

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Veröffentlicht in:	Journal of cell science 2005-01, Vol.118 (Pt 1), p.243-252
Hauptverfasser:	el-Remessy, Azza B, Bartoli, Manuela, Platt, Danial H, Fulton, David, Caldwell, Ruth B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Animals Apoptosis - drug effects Blotting, Western Caspase 3 Caspases - analysis Caspases - metabolism Cattle Cell Survival Cells, Cultured Dose-Response Relationship, Drug Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Glucose - pharmacology Models, Biological Oxidative Stress p38 Mitogen-Activated Protein Kinases - metabolism Peroxynitrous Acid - pharmacology Phosphatidylinositol 3-Kinases - chemistry Phosphatidylinositol 3-Kinases - metabolism Phosphorylation - drug effects Precipitin Tests Protein-Serine-Threonine Kinases - analysis Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - analysis Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt Retina - cytology Tyrosine - metabolism Vascular Endothelial Growth Factor A - metabolism
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