Abnormal accumulation of inter-α-trypsin inhibitor and hyaluronic acid in lichen sclerosus

Inter‐α‐trypsin inhibitor (ITI) is a recently identified extracellular hyaluronic acid (HA)‐binding protein which greatly improves extracellular HA stability. In lichen sclerosus (LS), a broad hyalinized zone of superficial dermis is the most prominent pathological change. To assess the pathogenic r...

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