Proteomic Analysis of Butyrate Effects and Loss of Butyrate Sensitivity in HT29 Colorectal Cancer Cells

Butyrate, a fermentation product of the large bowel microflora, is potentially protective against the development of colorectal cancer. In vitro, butyrate has been shown to induce apoptosis and inhibit proliferation in numerous cancer cell lines, including colorectal cancer. Although these tumor sup...

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Veröffentlicht in:	Journal of proteome research 2009-03, Vol.8 (3), p.1220-1227
Hauptverfasser:	Fung, Kim Y. C, Lewanowitsch, Tanya, Henderson, Steven T, Priebe, Ilka, Hoffmann, Peter, McColl, Shaun R, Lockett, Trevor, Head, Richard, Cosgrove, Leah J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - physiology Butyrates - pharmacology Cell Differentiation - physiology Colorectal Neoplasms - drug therapy Colorectal Neoplasms - metabolism Electrophoresis, Gel, Two-Dimensional HT29 Cells Humans Protective Agents - pharmacology Proteome - drug effects Proteome - metabolism Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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