Phosphorylation of glycosyl-phosphatidylinositol by phosphatidylinositol 3-kinase changes its properties as a substrate for phospholipases

Phosphatidylinositol 3-kinases (PI3K) phosphorylate the 3-position of the inositol ring of phosphatidylinositol-4,5-bisphosphate to produce phosphatidylinositol-3,4,5-trisphosphate. It is not clear whether PI3K can phosphorylate the inositol group in other biomolecules. We sought to determine whethe...

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Veröffentlicht in:	FEBS letters 2005-01, Vol.579 (1), p.59-65
Hauptverfasser:	Jones, David R., Pañeda, Covadonga, Villar, Ana Victoria, Alonso, Alicia, Goñi, Félix M., Bütikofer, Peter, Brodbeck, Urs, Shepherd, Peter R., Varela-Nieto, Isabel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Glycosyl-phosphatidylinositol Glycosylphosphatidylinositols - chemistry Glycosylphosphatidylinositols - metabolism Phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - metabolism Phospholipase D - metabolism Phosphorylation Rats Substrate Specificity Type C Phospholipases - metabolism
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