Serotype Chimeric and Fiber-Mutated Adenovirus Ad5/19p-HIT for Targeting Renal Cancer and Untargeting the Liver

Despite some advances, patients with advanced renal cell carcinoma (RCC) cannot usually be cured. Alteration of the natural tropism of adenoviruses may permit more specific gene transfer to target tissues. The aim of this study was to use novel targeting moieties for adenoviral gene therapy of RCC....

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Veröffentlicht in:	Human gene therapy 2009-06, Vol.20 (6), p.611-620
Hauptverfasser:	DIACONU, Iulia, DENBY, Laura, BAKER, Andrew H, HEMMINKI, Akseli, PESONEN, Sari, CERULLO, Vincenzo, BAUERSCHMITZ, Gerd J, GUSE, Kilian, RAJECKI, Maria, DIAS, Joao D, TAARI, Kimmo, KANERVA, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenovirus Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Carcinoma, Renal cell Care and treatment Cell Line, Tumor Disease Models, Animal Female Fundamental and applied biological sciences. Psychology Gene therapy Gene Transfer Techniques Genetic aspects Health aspects Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Injections, Intraperitoneal Injections, Intravenous Kidney Neoplasms - therapy Liver - drug effects Liver - metabolism Medical sciences Mice Mice, SCID Middle Aged Mutation - genetics Organ Specificity - drug effects Peptides - administration & dosage Peptides - pharmacology Physiological aspects Rats Serotyping Transduction, Genetic Transfusions. Complications. Transfusion reactions. Cell and gene therapy Viral proteins
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