Protections of SMND-309, a novel derivate of salvianolic acid B, on brain mitochondria contribute to injury amelioration in cerebral ischemia rats

SMND-309, a novel compound named (2E)-2-{6-[(E)-2-carboxylvinyl]-2,3-dihydroxyphenyl}-3-(3,4-dihydroxyphenyl) propenoic acid, is a new derivate of salvianolic acid B. The present study was conducted to investigate whether SMND-309 has a protective effect on brain injury after focal cerebral ischemia...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2009-08, Vol.16 (8), p.726-733
Hauptverfasser:	Tian, Jingwei, Fu, Fenghua, Li, Guisheng, Gao, Yubai, Zhang, Yunjuan, Meng, Qingsheng, Li, Changlu, Liu, Fu
Format:	Artikel
Sprache:	eng
Schlagworte:	(2E)-2-{6-[(E)-2-carboxylvinyl]-2,3-dihydroxyphenyl}-3-(3,4-dihydroxyphenyl) propenoic acid Animals Antioxidants - pharmacology Antioxidants - therapeutic use Benzofurans - metabolism Brain - metabolism Brain - pathology Brain Ischemia - drug therapy Caffeic Acids - pharmacology Caffeic Acids - therapeutic use Cerebral ischemia Chemical properties Drug therapy Energy metabolism Health aspects Immunocytochemistry Male Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Physiological aspects Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plants, Medicinal - chemistry Plants, Medicinal - metabolism Rats Rats, Sprague-Dawley Reactive oxygen species Salvia Salvia miltiorrhiza Salvia miltiorrhiza - chemistry Salvia miltiorrhiza - metabolism Salviolic acid derivative Superoxide dismutase
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