Antiangiogenic Activity of Semisynthetic Biotechnological Heparins: Low-Molecular-Weight–Sulfated Escherichia coli K5 Polysaccharide Derivatives as Fibroblast Growth Factor Antagonists

OBJECTIVE—Low-molecular-weight heparin (LMWH) exerts antitumor activity in clinical trials. The K5 polysaccharide from Escherichia coli has the same structure as the heparin precursor. Chemical and enzymatic modifications of K5 polysaccharide lead to the production of biotechnological heparin-like c...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2005-01, Vol.25 (1), p.71-76
Hauptverfasser:	Presta, Marco, Oreste, Pasqua, Zoppetti, Giorgio, Belleri, Mirella, Tanghetti, Elena, Leali, Daria, Urbinati, Chiara, Bugatti, Antonella, Ronca, Roberto, Nicoli, Stefania, Moroni, Emanuela, Stabile, Helena, Camozzi, Maura, Hernandez, German Andrés, Mitola, Stefania, Dell’Era, Patrizia, Rusnati, Marco, Ribatti, Domenico
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - biosynthesis Angiogenesis Inhibitors - genetics Animals Atherosclerosis (general aspects, experimental research) Bacterial Capsules Biological and medical sciences Blood and lymphatic vessels Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Cattle Cell Adhesion - physiology Cell Line Cell Proliferation - drug effects Chick Embryo CHO Cells - chemistry CHO Cells - metabolism Chorioallantoic Membrane - drug effects Cricetinae Cricetulus Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelial Cells - chemistry Endothelial Cells - metabolism Escherichia coli - chemistry Escherichia coli - genetics Fibroblast Growth Factor 2 - analogs & derivatives Fibroblast Growth Factor 2 - antagonists & inhibitors Fibroblast Growth Factor 2 - metabolism Fibroblast Growth Factors - analogs & derivatives Fibroblast Growth Factors - metabolism Genetic Engineering - methods Heparan Sulfate Proteoglycans - analogs & derivatives Heparan Sulfate Proteoglycans - deficiency Heparan Sulfate Proteoglycans - metabolism Heparin, Low-Molecular-Weight - biosynthesis Heparin, Low-Molecular-Weight - chemical synthesis Heparin, Low-Molecular-Weight - genetics Integrin alphaVbeta3 - metabolism Medical sciences Mice Neovascularization, Physiologic - drug effects Pharmacology. Drug treatments Polysaccharides, Bacterial - biosynthesis Polysaccharides, Bacterial - genetics
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