Chronic Sildenafil Improves Erectile Function and Endothelium-dependent Cavernosal Relaxations in Rats: Lack of Tachyphylaxis

Sildenafil is a widely-prescribed effective on-demand treatment of erectile dysfunction (ED). Chronic treatment with sildenafil could help patients with ED. The effects of an 8-week long treatment with sildenafil (60 mg/kg/d sc) in male Sprague Dawley rats were evaluated on electrically-elicited ere...

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Veröffentlicht in:	European urology 2005, Vol.47 (1), p.87-91
Hauptverfasser:	Behr-Roussel, Delphine, Gorny, Diane, Mevel, Katell, Caisey, Stéphanie, Bernabé, Jacques, Burgess, Gillian, Wayman, Chris, Alexandre, Laurent, Giuliano, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chronic administration Corpus cavernosum Endothelium Endothelium, Vascular - drug effects Erectile dysfunction Erectile Dysfunction - drug therapy Erectile Dysfunction - physiopathology Male Medical sciences Muscle Relaxation - drug effects Nephrology. Urinary tract diseases PDE-5 Penile Erection - drug effects Phosphodiesterase Inhibitors - pharmacology Piperazines - pharmacology Purines Rats Rats, Sprague-Dawley Sildenafil Sildenafil Citrate Sulfones Tachyphylaxis
Online-Zugang:	Volltext
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