Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection
Abstract Adoptive immune transfer plays an important role in clearance of hepatitis B virus (HBV) in chronic hepatitis B (CHB) patients. However, it is unclear whether cytokine-induced killer (CIK) cells could suppress HBV replication in CHB patients, especially if drug resistance develops. In this...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2009-07, Vol.132 (1), p.43-54 |
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| container_title | Clinical immunology (Orlando, Fla.) |
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| creator | Shi, Ming Fu, Junliang Shi, Feng Zhang, Bin Tang, Zirong Jin, Lei Fan, Zhenping Zhang, Zheng Chen, Liming Wang, Huifeng Lau, George K.K Wang, Fu-Sheng |
| description | Abstract Adoptive immune transfer plays an important role in clearance of hepatitis B virus (HBV) in chronic hepatitis B (CHB) patients. However, it is unclear whether cytokine-induced killer (CIK) cells could suppress HBV replication in CHB patients, especially if drug resistance develops. In this study, functional CIK cells were efficiently generated from 21 CHB patients and were transfused in an autologous manner. We found that CIK cells from the CHB patients displayed substantial proliferation and function. Administration of the CIK cells closely correlated with the decrease in the serum HBV load and improvement in liver function in some patients. The virological response rate in patients with baseline serum alanine aminotransferase (ALT) levels of > 40 U/L was higher than that in patients with baseline serum ALT levels of ≤ 40 U/L. Moreover, patients who had HBeAg loss or showed seroconversion generally had baseline serum ALT levels of > 40 U/L. No serious side effects were observed. This protocol represents an alternative immune therapeutic strategy for the disease. |
| doi_str_mv | 10.1016/j.clim.2009.03.001 |
| format | Article |
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However, it is unclear whether cytokine-induced killer (CIK) cells could suppress HBV replication in CHB patients, especially if drug resistance develops. In this study, functional CIK cells were efficiently generated from 21 CHB patients and were transfused in an autologous manner. We found that CIK cells from the CHB patients displayed substantial proliferation and function. Administration of the CIK cells closely correlated with the decrease in the serum HBV load and improvement in liver function in some patients. The virological response rate in patients with baseline serum alanine aminotransferase (ALT) levels of > 40 U/L was higher than that in patients with baseline serum ALT levels of ≤ 40 U/L. Moreover, patients who had HBeAg loss or showed seroconversion generally had baseline serum ALT levels of > 40 U/L. No serious side effects were observed. This protocol represents an alternative immune therapeutic strategy for the disease.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2009.03.001</identifier><identifier>PMID: 19328038</identifier><identifier>CODEN: CLIIFY</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adoptive Transfer - methods ; Adult ; Aged ; Alanine transaminase ; Allergy and Immunology ; Biological and medical sciences ; Cell proliferation ; Chronic hepatitis B ; Chronic infection ; Cytokine-induced killer cell ; Cytokine-Induced Killer Cells - cytology ; Cytokine-Induced Killer Cells - immunology ; Cytokine-Induced Killer Cells - transplantation ; Drug resistance ; Efficacy ; Female ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Hepatitis B ; hepatitis B e antigen ; Hepatitis B virus ; Hepatitis B virus - immunology ; Hepatitis B, Chronic - immunology ; Hepatitis B, Chronic - therapy ; Hepatitis B, Chronic - virology ; Human viral diseases ; Humans ; Infectious diseases ; Interferon-gamma - immunology ; Killer cells ; Liver ; Male ; Medical sciences ; Middle Aged ; Replication ; Safety ; Seroconversion ; Side effects ; Transfusion ; Transplantation, Autologous ; Treatment Outcome ; Viral diseases ; Viral hepatitis ; Virus Replication - immunology ; Young Adult</subject><ispartof>Clinical immunology (Orlando, Fla.), 2009-07, Vol.132 (1), p.43-54</ispartof><rights>2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-25bbeed2dbf9db2922f36ef8e96abf4a12540e7b6bdbc495065c63bb7ea91c823</citedby><cites>FETCH-LOGICAL-c470t-25bbeed2dbf9db2922f36ef8e96abf4a12540e7b6bdbc495065c63bb7ea91c823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1521661609000710$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21642073$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19328038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Ming</creatorcontrib><creatorcontrib>Fu, Junliang</creatorcontrib><creatorcontrib>Shi, Feng</creatorcontrib><creatorcontrib>Zhang, Bin</creatorcontrib><creatorcontrib>Tang, Zirong</creatorcontrib><creatorcontrib>Jin, Lei</creatorcontrib><creatorcontrib>Fan, Zhenping</creatorcontrib><creatorcontrib>Zhang, Zheng</creatorcontrib><creatorcontrib>Chen, Liming</creatorcontrib><creatorcontrib>Wang, Huifeng</creatorcontrib><creatorcontrib>Lau, George K.K</creatorcontrib><creatorcontrib>Wang, Fu-Sheng</creatorcontrib><title>Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>Abstract Adoptive immune transfer plays an important role in clearance of hepatitis B virus (HBV) in chronic hepatitis B (CHB) patients. However, it is unclear whether cytokine-induced killer (CIK) cells could suppress HBV replication in CHB patients, especially if drug resistance develops. In this study, functional CIK cells were efficiently generated from 21 CHB patients and were transfused in an autologous manner. We found that CIK cells from the CHB patients displayed substantial proliferation and function. Administration of the CIK cells closely correlated with the decrease in the serum HBV load and improvement in liver function in some patients. The virological response rate in patients with baseline serum alanine aminotransferase (ALT) levels of > 40 U/L was higher than that in patients with baseline serum ALT levels of ≤ 40 U/L. Moreover, patients who had HBeAg loss or showed seroconversion generally had baseline serum ALT levels of > 40 U/L. No serious side effects were observed. This protocol represents an alternative immune therapeutic strategy for the disease.</description><subject>Adoptive Transfer - methods</subject><subject>Adult</subject><subject>Aged</subject><subject>Alanine transaminase</subject><subject>Allergy and Immunology</subject><subject>Biological and medical sciences</subject><subject>Cell proliferation</subject><subject>Chronic hepatitis B</subject><subject>Chronic infection</subject><subject>Cytokine-induced killer cell</subject><subject>Cytokine-Induced Killer Cells - cytology</subject><subject>Cytokine-Induced Killer Cells - immunology</subject><subject>Cytokine-Induced Killer Cells - transplantation</subject><subject>Drug resistance</subject><subject>Efficacy</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Hepatitis B</subject><subject>hepatitis B e antigen</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - immunology</subject><subject>Hepatitis B, Chronic - immunology</subject><subject>Hepatitis B, Chronic - therapy</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interferon-gamma - immunology</subject><subject>Killer cells</subject><subject>Liver</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Replication</subject><subject>Safety</subject><subject>Seroconversion</subject><subject>Side effects</subject><subject>Transfusion</subject><subject>Transplantation, Autologous</subject><subject>Treatment Outcome</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Virus Replication - immunology</subject><subject>Young Adult</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks-OFCEQhztG466rL-DBcNFbtwV009OJMdGN_5JNPLieCdCFwwzTjNC9Zp7A1xYyHU086AkC368C9VVVPaXQUKDi5a4x3h0aBjA0wBsAeq-6pB2jdQ-8u7_uhaDionqU0g4AOsbEw-qCDpxtgG8uq5-3UU3JLsmFiQRL1DIHH76FJRFzmsPeTVi7aVwMjmTvvMdIDHqfiJu2Trs5kTsXlScRj94ZNZcybiLHvMMp3_5w85aYbQyTM2SL5Xx2ibwtsaVUsWhK6HH1wCqf8Mm6XlVf37-7vf5Y33z-8On6zU1t2h7mmnVaI45s1HYYNRsYs1yg3eAglLatoqxrAXst9KhNO3QgOiO41j2qgZoN41fVi3PdYwzfF0yzPLhUfqQmzJ-WoudsaMXwX5CB4LTdFJCdQRNDShGtPEZ3UPEkKcjiSe5k8SSLJwlcZk859GytvugDjn8iq5gMPF8BlYzyNlsyLv3mGBUtg55n7tWZw9y0O4dRJpM7n3W5mDsrx-D-_Y7Xf8UzklUpv8cTpl1Y4pR1SCoTkyC_lIkqAwVDHqaeAv8FiSvJ4Q</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Shi, Ming</creator><creator>Fu, Junliang</creator><creator>Shi, Feng</creator><creator>Zhang, Bin</creator><creator>Tang, Zirong</creator><creator>Jin, Lei</creator><creator>Fan, Zhenping</creator><creator>Zhang, Zheng</creator><creator>Chen, Liming</creator><creator>Wang, Huifeng</creator><creator>Lau, George K.K</creator><creator>Wang, Fu-Sheng</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection</title><author>Shi, Ming ; Fu, Junliang ; Shi, Feng ; Zhang, Bin ; Tang, Zirong ; Jin, Lei ; Fan, Zhenping ; Zhang, Zheng ; Chen, Liming ; Wang, Huifeng ; Lau, George K.K ; Wang, Fu-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-25bbeed2dbf9db2922f36ef8e96abf4a12540e7b6bdbc495065c63bb7ea91c823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adoptive Transfer - methods</topic><topic>Adult</topic><topic>Aged</topic><topic>Alanine transaminase</topic><topic>Allergy and Immunology</topic><topic>Biological and medical sciences</topic><topic>Cell proliferation</topic><topic>Chronic hepatitis B</topic><topic>Chronic infection</topic><topic>Cytokine-induced killer cell</topic><topic>Cytokine-Induced Killer Cells - cytology</topic><topic>Cytokine-Induced Killer Cells - immunology</topic><topic>Cytokine-Induced Killer Cells - transplantation</topic><topic>Drug resistance</topic><topic>Efficacy</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Hepatitis B</topic><topic>hepatitis B e antigen</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - immunology</topic><topic>Hepatitis B, Chronic - immunology</topic><topic>Hepatitis B, Chronic - therapy</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interferon-gamma - immunology</topic><topic>Killer cells</topic><topic>Liver</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Replication</topic><topic>Safety</topic><topic>Seroconversion</topic><topic>Side effects</topic><topic>Transfusion</topic><topic>Transplantation, Autologous</topic><topic>Treatment Outcome</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Virus Replication - immunology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shi, Ming</creatorcontrib><creatorcontrib>Fu, Junliang</creatorcontrib><creatorcontrib>Shi, Feng</creatorcontrib><creatorcontrib>Zhang, Bin</creatorcontrib><creatorcontrib>Tang, Zirong</creatorcontrib><creatorcontrib>Jin, Lei</creatorcontrib><creatorcontrib>Fan, Zhenping</creatorcontrib><creatorcontrib>Zhang, Zheng</creatorcontrib><creatorcontrib>Chen, Liming</creatorcontrib><creatorcontrib>Wang, Huifeng</creatorcontrib><creatorcontrib>Lau, George K.K</creatorcontrib><creatorcontrib>Wang, Fu-Sheng</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shi, Ming</au><au>Fu, Junliang</au><au>Shi, Feng</au><au>Zhang, Bin</au><au>Tang, Zirong</au><au>Jin, Lei</au><au>Fan, Zhenping</au><au>Zhang, Zheng</au><au>Chen, Liming</au><au>Wang, Huifeng</au><au>Lau, George K.K</au><au>Wang, Fu-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>132</volume><issue>1</issue><spage>43</spage><epage>54</epage><pages>43-54</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><coden>CLIIFY</coden><abstract>Abstract Adoptive immune transfer plays an important role in clearance of hepatitis B virus (HBV) in chronic hepatitis B (CHB) patients. However, it is unclear whether cytokine-induced killer (CIK) cells could suppress HBV replication in CHB patients, especially if drug resistance develops. In this study, functional CIK cells were efficiently generated from 21 CHB patients and were transfused in an autologous manner. We found that CIK cells from the CHB patients displayed substantial proliferation and function. Administration of the CIK cells closely correlated with the decrease in the serum HBV load and improvement in liver function in some patients. The virological response rate in patients with baseline serum alanine aminotransferase (ALT) levels of > 40 U/L was higher than that in patients with baseline serum ALT levels of ≤ 40 U/L. Moreover, patients who had HBeAg loss or showed seroconversion generally had baseline serum ALT levels of > 40 U/L. No serious side effects were observed. This protocol represents an alternative immune therapeutic strategy for the disease.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>19328038</pmid><doi>10.1016/j.clim.2009.03.001</doi><tpages>12</tpages></addata></record> |
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| ispartof | Clinical immunology (Orlando, Fla.), 2009-07, Vol.132 (1), p.43-54 |
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| subjects | Adoptive Transfer - methods Adult Aged Alanine transaminase Allergy and Immunology Biological and medical sciences Cell proliferation Chronic hepatitis B Chronic infection Cytokine-induced killer cell Cytokine-Induced Killer Cells - cytology Cytokine-Induced Killer Cells - immunology Cytokine-Induced Killer Cells - transplantation Drug resistance Efficacy Female Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Hepatitis B hepatitis B e antigen Hepatitis B virus Hepatitis B virus - immunology Hepatitis B, Chronic - immunology Hepatitis B, Chronic - therapy Hepatitis B, Chronic - virology Human viral diseases Humans Infectious diseases Interferon-gamma - immunology Killer cells Liver Male Medical sciences Middle Aged Replication Safety Seroconversion Side effects Transfusion Transplantation, Autologous Treatment Outcome Viral diseases Viral hepatitis Virus Replication - immunology Young Adult |
| title | Transfusion of autologous cytokine-induced killer cells inhibits viral replication in patients with chronic hepatitis B virus infection |
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