Synergy between Activin A and Gonadotropin-Releasing Hormone in Transcriptional Activation of the Rat Follicle-Stimulating Hormone-β Gene

Both activin and GnRH can independently stimulate expression of the FSHβ subunit gene. In this study, we used the gonadotrope-derived LβT2 cell line to investigate the potential interaction between activin and GnRH in regulating the transcriptional activity of the rat FSHβ gene promoter. Activin A a...

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Veröffentlicht in:	Molecular endocrinology (Baltimore, Md.) Md.), 2005-01, Vol.19 (1), p.237-254
Hauptverfasser:	Gregory, Susan J, Lacza, Charlemagne T, Detz, Alissa A, Xu, Shuyun, Petrillo, Laura A, Kaiser, Ursula B
Format:	Artikel
Sprache:	eng
Schlagworte:	Activins - pharmacology Animals Base Sequence Binding Sites Cell Line DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Follicle Stimulating Hormone, beta Subunit - genetics Follicle Stimulating Hormone, beta Subunit - pharmacology Gonadotropin-Releasing Hormone - pharmacology Humans Inhibin-beta Subunits - pharmacology MAP Kinase Signaling System Mice Molecular Sequence Data Mutation - genetics Nuclear Proteins - metabolism Promoter Regions, Genetic - genetics Rats Response Elements - genetics Smad2 Protein Smad3 Protein Smad4 Protein Trans-Activators - genetics Trans-Activators - metabolism Transcriptional Activation - drug effects Transcriptional Activation - genetics
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