Physical and functional link of the leukemia-associated factors AML1 and PML

The AML1-CBFβ transcription factor complex is the most frequent target of specific chromosome translocations in acute myeloid leukemia (AML). The promyelocytic leukemia (PML) gene is also frequently involved in AML-associated translocation. Here we report that a specific isoform PML I forms a comple...

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Veröffentlicht in:	Blood 2005-01, Vol.105 (1), p.292-300
Hauptverfasser:	Nguyen, Lan Anh, Pandolfi, Pier Paolo, Aikawa, Yukiko, Tagata, Yusuke, Ohki, Misao, Kitabayashi, Issay
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Amino Acid Sequence Animals Binding Sites Biological and medical sciences Cell Differentiation - drug effects Cell Line, Tumor Cell Nucleus - metabolism Core Binding Factor Alpha 2 Subunit DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism E1A-Associated p300 Protein Gene Expression Regulation, Neoplastic Granulocyte Colony-Stimulating Factor - pharmacology Hematologic and hematopoietic diseases Humans Leukemia - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mice Molecular Sequence Data Myeloid Cells - cytology Myeloid Cells - drug effects Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Promyelocytic Leukemia Protein Protein Binding Protein Isoforms - chemistry Protein Isoforms - genetics Protein Isoforms - metabolism Protein Structure, Tertiary Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Sequence Alignment Signal Transduction Trans-Activators - metabolism Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Tumor Suppressor Proteins
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