Pt nanoparticle-based highly sensitive platform for the enzyme-free amperometric sensing of H2O2
Highly sensitive electrochemical platform based on polymer supported Pt nanoparticles (nPts) for the amperometric sensing of H(2)O(2) at sub-nanomolar level without any redox mediator or enzyme is developed. The nPts are generated by the chemical reduction of precursor pre-organized on the electrode...
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Veröffentlicht in: | Biosensors & bioelectronics 2009-07, Vol.24 (11), p.3264-3268 |
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description | Highly sensitive electrochemical platform based on polymer supported Pt nanoparticles (nPts) for the amperometric sensing of H(2)O(2) at sub-nanomolar level without any redox mediator or enzyme is developed. The nPts are generated by the chemical reduction of precursor pre-organized on the electrode surface and characterized by field emission scanning electron microscopy, X-ray diffraction, spectral and electrochemical measurements. The cationic polymer poly(diallyldimethylammonium) chloride was used to assist the pre-organization of metal precursor. nPts on the electrode surface have an average size of 17 nm. The nanoparticles show excellent electrocatalytic activity towards oxidation of H(2)O(2) at less positive potential than the polycrystalline Pt electrode. Unlike the polycrystalline Pt electrode, the nanoparticle-based electrode does not undergo deactivation by surface oxides and other species in solution. Particle loading on the electrode surface controls the electrocatalytic activity. The nanoparticle-based electrode is highly sensitive (9.15 microA/mM) and display linear response up to 3 mM. It could detect 0.5 nM (S/N=5) of H(2)O(2) under hydrodynamic condition in neutral solution and the electrode is highly stable. The detection limit achieved is significantly lower than the other nanoparticle-based electrodes. The excellent performance of the electrode is ascribed to the good catalytic activity of the particle and ensemble behavior of the nanoparticle-modified electrode. The analytical performance of the electrode in the development of glucose biosensor is demonstrated. The biosensor is used for the sensing of glucose in the micromolar level in neutral pH. |
doi_str_mv | 10.1016/j.bios.2009.04.015 |
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The nPts are generated by the chemical reduction of precursor pre-organized on the electrode surface and characterized by field emission scanning electron microscopy, X-ray diffraction, spectral and electrochemical measurements. The cationic polymer poly(diallyldimethylammonium) chloride was used to assist the pre-organization of metal precursor. nPts on the electrode surface have an average size of 17 nm. The nanoparticles show excellent electrocatalytic activity towards oxidation of H(2)O(2) at less positive potential than the polycrystalline Pt electrode. Unlike the polycrystalline Pt electrode, the nanoparticle-based electrode does not undergo deactivation by surface oxides and other species in solution. Particle loading on the electrode surface controls the electrocatalytic activity. The nanoparticle-based electrode is highly sensitive (9.15 microA/mM) and display linear response up to 3 mM. It could detect 0.5 nM (S/N=5) of H(2)O(2) under hydrodynamic condition in neutral solution and the electrode is highly stable. The detection limit achieved is significantly lower than the other nanoparticle-based electrodes. The excellent performance of the electrode is ascribed to the good catalytic activity of the particle and ensemble behavior of the nanoparticle-modified electrode. The analytical performance of the electrode in the development of glucose biosensor is demonstrated. The biosensor is used for the sensing of glucose in the micromolar level in neutral pH.</description><identifier>ISSN: 0956-5663</identifier><identifier>EISSN: 1873-4235</identifier><identifier>DOI: 10.1016/j.bios.2009.04.015</identifier><identifier>PMID: 19442506</identifier><language>eng</language><publisher>Kidlington: Elsevier</publisher><subject>Biological and medical sciences ; Biosensing Techniques - instrumentation ; Biosensors ; Biotechnology ; Chemistry ; Electrochemistry - instrumentation ; Electrodes ; Enzymes ; Equipment Design ; Equipment Failure Analysis ; Fundamental and applied biological sciences. Psychology ; Glucose - analysis ; Glucose - chemistry ; Glucose Oxidase - chemistry ; Hydrogen Peroxide - analysis ; Methods. Procedures. Technologies ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Platinum - chemistry ; Sensitivity and Specificity ; Various methods and equipments</subject><ispartof>Biosensors & bioelectronics, 2009-07, Vol.24 (11), p.3264-3268</ispartof><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-9ce9d563869efb8bb8ab2034b24d49b318a40f26f8283ba041f2bfe4df2d66703</citedby><cites>FETCH-LOGICAL-c434t-9ce9d563869efb8bb8ab2034b24d49b318a40f26f8283ba041f2bfe4df2d66703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21674345$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19442506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHAKRABORTY, Sudip</creatorcontrib><creatorcontrib>RETNA RAJ, C</creatorcontrib><title>Pt nanoparticle-based highly sensitive platform for the enzyme-free amperometric sensing of H2O2</title><title>Biosensors & bioelectronics</title><addtitle>Biosens Bioelectron</addtitle><description>Highly sensitive electrochemical platform based on polymer supported Pt nanoparticles (nPts) for the amperometric sensing of H(2)O(2) at sub-nanomolar level without any redox mediator or enzyme is developed. The nPts are generated by the chemical reduction of precursor pre-organized on the electrode surface and characterized by field emission scanning electron microscopy, X-ray diffraction, spectral and electrochemical measurements. The cationic polymer poly(diallyldimethylammonium) chloride was used to assist the pre-organization of metal precursor. nPts on the electrode surface have an average size of 17 nm. The nanoparticles show excellent electrocatalytic activity towards oxidation of H(2)O(2) at less positive potential than the polycrystalline Pt electrode. Unlike the polycrystalline Pt electrode, the nanoparticle-based electrode does not undergo deactivation by surface oxides and other species in solution. Particle loading on the electrode surface controls the electrocatalytic activity. The nanoparticle-based electrode is highly sensitive (9.15 microA/mM) and display linear response up to 3 mM. It could detect 0.5 nM (S/N=5) of H(2)O(2) under hydrodynamic condition in neutral solution and the electrode is highly stable. The detection limit achieved is significantly lower than the other nanoparticle-based electrodes. The excellent performance of the electrode is ascribed to the good catalytic activity of the particle and ensemble behavior of the nanoparticle-modified electrode. The analytical performance of the electrode in the development of glucose biosensor is demonstrated. The biosensor is used for the sensing of glucose in the micromolar level in neutral pH.</description><subject>Biological and medical sciences</subject><subject>Biosensing Techniques - instrumentation</subject><subject>Biosensors</subject><subject>Biotechnology</subject><subject>Chemistry</subject><subject>Electrochemistry - instrumentation</subject><subject>Electrodes</subject><subject>Enzymes</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose - analysis</subject><subject>Glucose - chemistry</subject><subject>Glucose Oxidase - chemistry</subject><subject>Hydrogen Peroxide - analysis</subject><subject>Methods. Procedures. 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Psychology</topic><topic>Glucose - analysis</topic><topic>Glucose - chemistry</topic><topic>Glucose Oxidase - chemistry</topic><topic>Hydrogen Peroxide - analysis</topic><topic>Methods. Procedures. Technologies</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - ultrastructure</topic><topic>Platinum - chemistry</topic><topic>Sensitivity and Specificity</topic><topic>Various methods and equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHAKRABORTY, Sudip</creatorcontrib><creatorcontrib>RETNA RAJ, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biosensors & bioelectronics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHAKRABORTY, Sudip</au><au>RETNA RAJ, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pt nanoparticle-based highly sensitive platform for the enzyme-free amperometric sensing of H2O2</atitle><jtitle>Biosensors & bioelectronics</jtitle><addtitle>Biosens Bioelectron</addtitle><date>2009-07-15</date><risdate>2009</risdate><volume>24</volume><issue>11</issue><spage>3264</spage><epage>3268</epage><pages>3264-3268</pages><issn>0956-5663</issn><eissn>1873-4235</eissn><abstract>Highly sensitive electrochemical platform based on polymer supported Pt nanoparticles (nPts) for the amperometric sensing of H(2)O(2) at sub-nanomolar level without any redox mediator or enzyme is developed. The nPts are generated by the chemical reduction of precursor pre-organized on the electrode surface and characterized by field emission scanning electron microscopy, X-ray diffraction, spectral and electrochemical measurements. The cationic polymer poly(diallyldimethylammonium) chloride was used to assist the pre-organization of metal precursor. nPts on the electrode surface have an average size of 17 nm. The nanoparticles show excellent electrocatalytic activity towards oxidation of H(2)O(2) at less positive potential than the polycrystalline Pt electrode. Unlike the polycrystalline Pt electrode, the nanoparticle-based electrode does not undergo deactivation by surface oxides and other species in solution. Particle loading on the electrode surface controls the electrocatalytic activity. The nanoparticle-based electrode is highly sensitive (9.15 microA/mM) and display linear response up to 3 mM. It could detect 0.5 nM (S/N=5) of H(2)O(2) under hydrodynamic condition in neutral solution and the electrode is highly stable. The detection limit achieved is significantly lower than the other nanoparticle-based electrodes. The excellent performance of the electrode is ascribed to the good catalytic activity of the particle and ensemble behavior of the nanoparticle-modified electrode. The analytical performance of the electrode in the development of glucose biosensor is demonstrated. The biosensor is used for the sensing of glucose in the micromolar level in neutral pH.</abstract><cop>Kidlington</cop><pub>Elsevier</pub><pmid>19442506</pmid><doi>10.1016/j.bios.2009.04.015</doi><tpages>5</tpages></addata></record> |
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subjects | Biological and medical sciences Biosensing Techniques - instrumentation Biosensors Biotechnology Chemistry Electrochemistry - instrumentation Electrodes Enzymes Equipment Design Equipment Failure Analysis Fundamental and applied biological sciences. Psychology Glucose - analysis Glucose - chemistry Glucose Oxidase - chemistry Hydrogen Peroxide - analysis Methods. Procedures. Technologies Nanoparticles - chemistry Nanoparticles - ultrastructure Platinum - chemistry Sensitivity and Specificity Various methods and equipments |
title | Pt nanoparticle-based highly sensitive platform for the enzyme-free amperometric sensing of H2O2 |
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