Transcription factors, pancreatic development, and β-cell maintenance

Transcription factors, pancreatic development, and β-cell maintenance

Transcription factors play an important role during pancreatic development ensuring normal differentiation of the islet endocrine cells. In mature β-cells, expression of specific transcription factors is essential in maintaining normal β-cell function.

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Bibliographische Detailangaben
Veröffentlicht in:Biochemical and biophysical research communications 2005-01, Vol.326 (4), p.699-702
Hauptverfasser: Cerf, M.E., Muller, C.J.F., Du Toit, D.F., Louw, J., Wolfe-Coote, S.A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Differentiation
Development
Diabetes
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - pathology
Gene Expression Regulation, Developmental
Humans
Islets of Langerhans - growth & development
Islets of Langerhans - metabolism
Islets of Langerhans - pathology
Pancreas
Pancreas - embryology
Pancreas - growth & development
Pancreas - metabolism
Pancreas - pathology
Transcription factors
Transcription Factors - metabolism
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Beschreibung
Zusammenfassung:Transcription factors play an important role during pancreatic development ensuring normal differentiation of the islet endocrine cells. In mature β-cells, expression of specific transcription factors is essential in maintaining normal β-cell function.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2004.10.217