Radiolabeling of monoclonal anti-vascular endothelial growth factor receptor 1 (VEGFR 1) with (177)Lu for potential use in radioimmunotherapy

The main goal of this study was to optimize the radioimmunoconjugation of monoclonal anti-vascular endothelial growth factor receptor 1 (VEGFR 1) with (177)Lu as a potential angiogenic molecular tracer for radioimmunotherapy (RIT). For a successful radiolabeling, we chose cysteine derivative DTPA-NC...

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Veröffentlicht in:	Applied radiation and isotopes 2009-07, Vol.67 (7-8), p.1185-1189
Hauptverfasser:	Lee, So-Young, Hong, Young-Don, Pyun, Mi-Sun, Felipe, Penelope M, Choi, Sun-Ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Carcinoma, Non-Small-Cell Lung - radiotherapy Cell Line, Tumor Humans Immunoconjugates - pharmacokinetics Isotope Labeling Lutetium - therapeutic use Mice Neovascularization, Pathologic - radiotherapy Radioimmunotherapy - methods Tissue Distribution Vascular Endothelial Growth Factor Receptor-1 - therapeutic use Xenograft Model Antitumor Assays
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