Combination with allogenic bone reduces early absorption of β-tricalcium phosphate (β-TCP) and enhances the role as a bone regeneration scaffold. Experimental animal study in rat mandibular bone defects
β-tricalcium phosphate (β-TCP) was grafted into rat mandibular bone defects to assess its potential as a scaffold material for bone regeneration. For this purpose, β-TCP (TCP), allogenic bone (Allograft), and allogenic bone combined with β-TCP (Combined) were employed as graft materials. To the left...
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| Veröffentlicht in: | Dental Materials Journal 2009, Vol.28(2), pp.153-161 |
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| creator | HIROTA, Makoto MATSUI, Yoshiro MIZUKI, Nobuyuki KISHI, Teruki WATANUKI, Kei OZAWA, Tomomichi FUKUI, Takafumi SHOJI, Shihomi ADACHI, Makoto MONDEN, Yuka IWAI, Toshinori TOHNAI, Iwai |
| description | β-tricalcium phosphate (β-TCP) was grafted into rat mandibular bone defects to assess its potential as a scaffold material for bone regeneration. For this purpose, β-TCP (TCP), allogenic bone (Allograft), and allogenic bone combined with β-TCP (Combined) were employed as graft materials. To the left side of the graft materials in the bone defects, platelet-rich plasma (PRP) was added. The rats were sacrificed at one, three, and five weeks. Bone formation rate (BFR), remaining β-TCP rate (RTR), β-TCP absorption rate (TAR), whole amount of β-TCP (WTCP), and total rate of BFR and RTR (TBR) were measured. Combined showed equivalent BFR to Allograft at five weeks, and showed higher RTR at one week and higher BFR at five weeks than TCP. Combined with PRP showed higher TAR than that without PRP at three weeks. Therefore, combination with allogenic bone showed reduced β-TCP absorption, hence enhancing the role of β-TCP in bone regeneration. These findings suggested that β-TCP is a better scaffold for bone regeneration if its early absorption is reduced when used in combination with an osteogenic material. |
| doi_str_mv | 10.4012/dmj.28.153 |
| format | Article |
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Experimental animal study in rat mandibular bone defects</title><source>MEDLINE</source><source>J-STAGE日本語サイト (Free Access)</source><source>Freely Accessible Japanese Titles</source><source>EZB Electronic Journals Library</source><creator>HIROTA, Makoto ; MATSUI, Yoshiro ; MIZUKI, Nobuyuki ; KISHI, Teruki ; WATANUKI, Kei ; OZAWA, Tomomichi ; FUKUI, Takafumi ; SHOJI, Shihomi ; ADACHI, Makoto ; MONDEN, Yuka ; IWAI, Toshinori ; TOHNAI, Iwai</creator><creatorcontrib>HIROTA, Makoto ; MATSUI, Yoshiro ; MIZUKI, Nobuyuki ; KISHI, Teruki ; WATANUKI, Kei ; OZAWA, Tomomichi ; FUKUI, Takafumi ; SHOJI, Shihomi ; ADACHI, Makoto ; MONDEN, Yuka ; IWAI, Toshinori ; TOHNAI, Iwai</creatorcontrib><description>β-tricalcium phosphate (β-TCP) was grafted into rat mandibular bone defects to assess its potential as a scaffold material for bone regeneration. For this purpose, β-TCP (TCP), allogenic bone (Allograft), and allogenic bone combined with β-TCP (Combined) were employed as graft materials. To the left side of the graft materials in the bone defects, platelet-rich plasma (PRP) was added. The rats were sacrificed at one, three, and five weeks. Bone formation rate (BFR), remaining β-TCP rate (RTR), β-TCP absorption rate (TAR), whole amount of β-TCP (WTCP), and total rate of BFR and RTR (TBR) were measured. Combined showed equivalent BFR to Allograft at five weeks, and showed higher RTR at one week and higher BFR at five weeks than TCP. Combined with PRP showed higher TAR than that without PRP at three weeks. Therefore, combination with allogenic bone showed reduced β-TCP absorption, hence enhancing the role of β-TCP in bone regeneration. These findings suggested that β-TCP is a better scaffold for bone regeneration if its early absorption is reduced when used in combination with an osteogenic material.</description><identifier>ISSN: 0287-4547</identifier><identifier>EISSN: 1881-1361</identifier><identifier>DOI: 10.4012/dmj.28.153</identifier><identifier>PMID: 19496394</identifier><language>eng</language><publisher>Japan: The Japanese Society for Dental Materials and Devices</publisher><subject>Absorbable Implants ; Animals ; Biocompatible Materials - therapeutic use ; Bone regeneration ; Bone Regeneration - physiology ; Bone Substitutes - therapeutic use ; Bone Transplantation - methods ; Calcium Phosphates - therapeutic use ; Dentistry ; Disease Models, Animal ; Male ; Mandible - pathology ; Mandibular Diseases - pathology ; Mandibular Diseases - surgery ; Microscopy, Electron, Scanning ; Osteogenesis - physiology ; Platelet-Rich Plasma ; Porosity ; Rats ; Rats, Wistar ; Scaffold ; Surface Properties ; Time Factors ; Tissue Scaffolds ; β-TCP</subject><ispartof>Dental Materials Journal, 2009, Vol.28(2), pp.153-161</ispartof><rights>2009 The Japanese Society for Dental Materials and Devices</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-216a73f13e3a8591858cc93b2e1c217e6ae1ff6bce1ea20ad9eb63417b10a6b53</citedby><cites>FETCH-LOGICAL-c467t-216a73f13e3a8591858cc93b2e1c217e6ae1ff6bce1ea20ad9eb63417b10a6b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19496394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HIROTA, Makoto</creatorcontrib><creatorcontrib>MATSUI, Yoshiro</creatorcontrib><creatorcontrib>MIZUKI, Nobuyuki</creatorcontrib><creatorcontrib>KISHI, Teruki</creatorcontrib><creatorcontrib>WATANUKI, Kei</creatorcontrib><creatorcontrib>OZAWA, Tomomichi</creatorcontrib><creatorcontrib>FUKUI, Takafumi</creatorcontrib><creatorcontrib>SHOJI, Shihomi</creatorcontrib><creatorcontrib>ADACHI, Makoto</creatorcontrib><creatorcontrib>MONDEN, Yuka</creatorcontrib><creatorcontrib>IWAI, Toshinori</creatorcontrib><creatorcontrib>TOHNAI, Iwai</creatorcontrib><title>Combination with allogenic bone reduces early absorption of β-tricalcium phosphate (β-TCP) and enhances the role as a bone regeneration scaffold. Experimental animal study in rat mandibular bone defects</title><title>Dental Materials Journal</title><addtitle>Dent. Mater. J.</addtitle><description>β-tricalcium phosphate (β-TCP) was grafted into rat mandibular bone defects to assess its potential as a scaffold material for bone regeneration. For this purpose, β-TCP (TCP), allogenic bone (Allograft), and allogenic bone combined with β-TCP (Combined) were employed as graft materials. To the left side of the graft materials in the bone defects, platelet-rich plasma (PRP) was added. The rats were sacrificed at one, three, and five weeks. Bone formation rate (BFR), remaining β-TCP rate (RTR), β-TCP absorption rate (TAR), whole amount of β-TCP (WTCP), and total rate of BFR and RTR (TBR) were measured. Combined showed equivalent BFR to Allograft at five weeks, and showed higher RTR at one week and higher BFR at five weeks than TCP. Combined with PRP showed higher TAR than that without PRP at three weeks. Therefore, combination with allogenic bone showed reduced β-TCP absorption, hence enhancing the role of β-TCP in bone regeneration. These findings suggested that β-TCP is a better scaffold for bone regeneration if its early absorption is reduced when used in combination with an osteogenic material.</description><subject>Absorbable Implants</subject><subject>Animals</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Bone regeneration</subject><subject>Bone Regeneration - physiology</subject><subject>Bone Substitutes - therapeutic use</subject><subject>Bone Transplantation - methods</subject><subject>Calcium Phosphates - therapeutic use</subject><subject>Dentistry</subject><subject>Disease Models, Animal</subject><subject>Male</subject><subject>Mandible - pathology</subject><subject>Mandibular Diseases - pathology</subject><subject>Mandibular Diseases - surgery</subject><subject>Microscopy, Electron, Scanning</subject><subject>Osteogenesis - physiology</subject><subject>Platelet-Rich Plasma</subject><subject>Porosity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Scaffold</subject><subject>Surface Properties</subject><subject>Time Factors</subject><subject>Tissue Scaffolds</subject><subject>β-TCP</subject><issn>0287-4547</issn><issn>1881-1361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc9u1DAQhy0EotvChQdAPiGKlCW2s4lzQmhV_kiV4FDO0diZNF45drAdwb4Wz4F4JlyyLZeZkebTNxr9CHnBym1VMv62nw5bLrdsJx6RDZOSFUzU7DHZlFw2RbWrmjNyHuOhLKu2lvIpOWNtnkRbbcjvvZ-UcZCMd_SHSSMFa_0tOqOp8g5pwH7RGClCsEcKKvow_4P9QP_8KlIwGqw2y0Tn0cd5hIT0dV7c7L9eUnA9RTeCuzOkMdu8RQqRwr08X8KwXo8ahsHbfkuvfs4YzIQugc0OM-UW09IfqXE003TKYqMWC2H19DigTvEZeTKAjfj81C_Itw9XN_tPxfWXj5_3768LXdVNKjiroREDEyhA7lomd1LrViiOTHPWYA3IhqFWGhkCL6FvUdWiYo1iJdRqJy7Iq9U7B_99wZi6yUSN1oJDv8SubgSvqqrM4JsV1MHHGHDo5vwXhGPHyu4uuy5n13HZ5ewy_PJkXdSE_X_0FFYG3q3AISa4xQcAQjLa4r2LryUrHzZ6hNChE38B_XayCg</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>HIROTA, Makoto</creator><creator>MATSUI, Yoshiro</creator><creator>MIZUKI, Nobuyuki</creator><creator>KISHI, Teruki</creator><creator>WATANUKI, Kei</creator><creator>OZAWA, Tomomichi</creator><creator>FUKUI, Takafumi</creator><creator>SHOJI, Shihomi</creator><creator>ADACHI, Makoto</creator><creator>MONDEN, Yuka</creator><creator>IWAI, Toshinori</creator><creator>TOHNAI, Iwai</creator><general>The Japanese Society for Dental Materials and Devices</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090301</creationdate><title>Combination with allogenic bone reduces early absorption of β-tricalcium phosphate (β-TCP) and enhances the role as a bone regeneration scaffold. Experimental animal study in rat mandibular bone defects</title><author>HIROTA, Makoto ; MATSUI, Yoshiro ; MIZUKI, Nobuyuki ; KISHI, Teruki ; WATANUKI, Kei ; OZAWA, Tomomichi ; FUKUI, Takafumi ; SHOJI, Shihomi ; ADACHI, Makoto ; MONDEN, Yuka ; IWAI, Toshinori ; TOHNAI, Iwai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-216a73f13e3a8591858cc93b2e1c217e6ae1ff6bce1ea20ad9eb63417b10a6b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Absorbable Implants</topic><topic>Animals</topic><topic>Biocompatible Materials - therapeutic use</topic><topic>Bone regeneration</topic><topic>Bone Regeneration - physiology</topic><topic>Bone Substitutes - therapeutic use</topic><topic>Bone Transplantation - methods</topic><topic>Calcium Phosphates - therapeutic use</topic><topic>Dentistry</topic><topic>Disease Models, Animal</topic><topic>Male</topic><topic>Mandible - pathology</topic><topic>Mandibular Diseases - pathology</topic><topic>Mandibular Diseases - surgery</topic><topic>Microscopy, Electron, Scanning</topic><topic>Osteogenesis - physiology</topic><topic>Platelet-Rich Plasma</topic><topic>Porosity</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Scaffold</topic><topic>Surface Properties</topic><topic>Time Factors</topic><topic>Tissue Scaffolds</topic><topic>β-TCP</topic><toplevel>online_resources</toplevel><creatorcontrib>HIROTA, Makoto</creatorcontrib><creatorcontrib>MATSUI, Yoshiro</creatorcontrib><creatorcontrib>MIZUKI, Nobuyuki</creatorcontrib><creatorcontrib>KISHI, Teruki</creatorcontrib><creatorcontrib>WATANUKI, Kei</creatorcontrib><creatorcontrib>OZAWA, Tomomichi</creatorcontrib><creatorcontrib>FUKUI, Takafumi</creatorcontrib><creatorcontrib>SHOJI, Shihomi</creatorcontrib><creatorcontrib>ADACHI, Makoto</creatorcontrib><creatorcontrib>MONDEN, Yuka</creatorcontrib><creatorcontrib>IWAI, Toshinori</creatorcontrib><creatorcontrib>TOHNAI, Iwai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Dental Materials Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HIROTA, Makoto</au><au>MATSUI, Yoshiro</au><au>MIZUKI, Nobuyuki</au><au>KISHI, Teruki</au><au>WATANUKI, Kei</au><au>OZAWA, Tomomichi</au><au>FUKUI, Takafumi</au><au>SHOJI, Shihomi</au><au>ADACHI, Makoto</au><au>MONDEN, Yuka</au><au>IWAI, Toshinori</au><au>TOHNAI, Iwai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination with allogenic bone reduces early absorption of β-tricalcium phosphate (β-TCP) and enhances the role as a bone regeneration scaffold. Experimental animal study in rat mandibular bone defects</atitle><jtitle>Dental Materials Journal</jtitle><addtitle>Dent. Mater. J.</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>28</volume><issue>2</issue><spage>153</spage><epage>161</epage><pages>153-161</pages><issn>0287-4547</issn><eissn>1881-1361</eissn><abstract>β-tricalcium phosphate (β-TCP) was grafted into rat mandibular bone defects to assess its potential as a scaffold material for bone regeneration. For this purpose, β-TCP (TCP), allogenic bone (Allograft), and allogenic bone combined with β-TCP (Combined) were employed as graft materials. To the left side of the graft materials in the bone defects, platelet-rich plasma (PRP) was added. The rats were sacrificed at one, three, and five weeks. Bone formation rate (BFR), remaining β-TCP rate (RTR), β-TCP absorption rate (TAR), whole amount of β-TCP (WTCP), and total rate of BFR and RTR (TBR) were measured. Combined showed equivalent BFR to Allograft at five weeks, and showed higher RTR at one week and higher BFR at five weeks than TCP. Combined with PRP showed higher TAR than that without PRP at three weeks. Therefore, combination with allogenic bone showed reduced β-TCP absorption, hence enhancing the role of β-TCP in bone regeneration. These findings suggested that β-TCP is a better scaffold for bone regeneration if its early absorption is reduced when used in combination with an osteogenic material.</abstract><cop>Japan</cop><pub>The Japanese Society for Dental Materials and Devices</pub><pmid>19496394</pmid><doi>10.4012/dmj.28.153</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Dental Materials Journal, 2009, Vol.28(2), pp.153-161 |
| issn | 0287-4547 1881-1361 |
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| source | MEDLINE; J-STAGE日本語サイト (Free Access); Freely Accessible Japanese Titles; EZB Electronic Journals Library |
| subjects | Absorbable Implants Animals Biocompatible Materials - therapeutic use Bone regeneration Bone Regeneration - physiology Bone Substitutes - therapeutic use Bone Transplantation - methods Calcium Phosphates - therapeutic use Dentistry Disease Models, Animal Male Mandible - pathology Mandibular Diseases - pathology Mandibular Diseases - surgery Microscopy, Electron, Scanning Osteogenesis - physiology Platelet-Rich Plasma Porosity Rats Rats, Wistar Scaffold Surface Properties Time Factors Tissue Scaffolds β-TCP |
| title | Combination with allogenic bone reduces early absorption of β-tricalcium phosphate (β-TCP) and enhances the role as a bone regeneration scaffold. Experimental animal study in rat mandibular bone defects |
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