Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid–based proteasome inhibitors

The anticancer potency of green tea and its individual components is being intensely investigated, and some cancer patients already self-medicate with this “miracle herb” in hopes of augmenting the anticancer outcome of their chemotherapy. Bortezomib (BZM) is a proteasome inhibitor in clinical use f...

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Veröffentlicht in:	Blood 2009-06, Vol.113 (23), p.5927-5937
Hauptverfasser:	Golden, Encouse B., Lam, Philip Y., Kardosh, Adel, Gaffney, Kevin J., Cadenas, Enrique, Louie, Stan G., Petasis, Nicos A., Chen, Thomas C., Schönthal, Axel H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - antagonists & inhibitors Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Biological and medical sciences Boronic Acids - antagonists & inhibitors Boronic Acids - chemistry Boronic Acids - pharmacology Bortezomib Cell Line, Tumor Chemotherapy Color Cytoprotection - drug effects Endoplasmic Reticulum - drug effects Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Glioblastoma - pathology Humans Medical sciences Mice Mice, Nude Molecular Structure Pharmacology. Drug treatments Phenols - pharmacology Plant Extracts - chemistry Plant Extracts - pharmacology Polyphenols Proteasome Endopeptidase Complex - metabolism Proteasome Inhibitors Pyrazines - antagonists & inhibitors Pyrazines - pharmacology Stress, Physiological - drug effects Tea - chemistry
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