Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 6: 3D hydrogels with positive and negative surface charges and polyelectrolyte complexes in spinal cord injury repair
Macroporous hydrogels are artificial biomaterials commonly used in tissue engineering, including central nervous system (CNS) repair. Their physical properties may be modified to improve their adhesion properties and promote tissue regeneration. We implanted four types of hydrogels based on 2-hydrox...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2009-07, Vol.20 (7), p.1571-1577 |
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| creator | Hejcl, A Lesný, P Prádný, M Sedý, J Zámecník, J Jendelová, P Michálek, J Syková, E |
| description | Macroporous hydrogels are artificial biomaterials commonly used in tissue engineering, including central nervous system (CNS) repair. Their physical properties may be modified to improve their adhesion properties and promote tissue regeneration. We implanted four types of hydrogels based on 2-hydroxyethyl methacrylate (HEMA) with different surface charges inside a spinal cord hemisection cavity at the Th8 level in rats. The spinal cords were processed 1 and 6 months after implantation and histologically evaluated. Connective tissue deposition was most abundant in the hydrogels with positively-charged functional groups. Axonal regeneration was promoted in hydrogels carrying charged functional groups; hydrogels with positively charged functional groups showed increased axonal ingrowth into the central parts of the implant. Few astrocytes grew into the hydrogels. Our study shows that HEMA-based hydrogels carrying charged functional groups improve axonal ingrowth inside the implants compared to implants without any charge. Further, positively charged functional groups promote connective tissue infiltration and extended axonal regeneration inside a hydrogel bridge. |
| doi_str_mv | 10.1007/s10856-009-3714-4 |
| format | Article |
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Part 6: 3D hydrogels with positive and negative surface charges and polyelectrolyte complexes in spinal cord injury repair</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Hejcl, A ; Lesný, P ; Prádný, M ; Sedý, J ; Zámecník, J ; Jendelová, P ; Michálek, J ; Syková, E</creator><creatorcontrib>Hejcl, A ; Lesný, P ; Prádný, M ; Sedý, J ; Zámecník, J ; Jendelová, P ; Michálek, J ; Syková, E</creatorcontrib><description>Macroporous hydrogels are artificial biomaterials commonly used in tissue engineering, including central nervous system (CNS) repair. Their physical properties may be modified to improve their adhesion properties and promote tissue regeneration. We implanted four types of hydrogels based on 2-hydroxyethyl methacrylate (HEMA) with different surface charges inside a spinal cord hemisection cavity at the Th8 level in rats. The spinal cords were processed 1 and 6 months after implantation and histologically evaluated. Connective tissue deposition was most abundant in the hydrogels with positively-charged functional groups. Axonal regeneration was promoted in hydrogels carrying charged functional groups; hydrogels with positively charged functional groups showed increased axonal ingrowth into the central parts of the implant. Few astrocytes grew into the hydrogels. Our study shows that HEMA-based hydrogels carrying charged functional groups improve axonal ingrowth inside the implants compared to implants without any charge. Further, positively charged functional groups promote connective tissue infiltration and extended axonal regeneration inside a hydrogel bridge.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-009-3714-4</identifier><identifier>PMID: 19252968</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Animals ; Biocompatible Materials - therapeutic use ; Biomaterials ; Biomedical Engineering and Bioengineering ; Biomedical materials ; Ceramics ; Chemistry and Materials Science ; Composites ; Glass ; Guided Tissue Regeneration - methods ; Hydrogels ; Hydrogels - therapeutic use ; Male ; Materials Science ; Materials Testing ; Methacrylates - therapeutic use ; Natural Materials ; Nerve Regeneration ; Nervous system ; Polymer Sciences ; Porosity ; Rats ; Rats, Wistar ; Regenerative Medicine/Tissue Engineering ; Spinal Cord Injuries - pathology ; Spinal Cord Injuries - therapy ; Static Electricity ; Surface Properties ; Surfaces and Interfaces ; Thin Films ; Thoracic Vertebrae - injuries ; Thoracic Vertebrae - pathology ; Tissue engineering ; Treatment Outcome</subject><ispartof>Journal of materials science. 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Part 6: 3D hydrogels with positive and negative surface charges and polyelectrolyte complexes in spinal cord injury repair</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci: Mater Med</addtitle><addtitle>J Mater Sci Mater Med</addtitle><description>Macroporous hydrogels are artificial biomaterials commonly used in tissue engineering, including central nervous system (CNS) repair. Their physical properties may be modified to improve their adhesion properties and promote tissue regeneration. We implanted four types of hydrogels based on 2-hydroxyethyl methacrylate (HEMA) with different surface charges inside a spinal cord hemisection cavity at the Th8 level in rats. The spinal cords were processed 1 and 6 months after implantation and histologically evaluated. Connective tissue deposition was most abundant in the hydrogels with positively-charged functional groups. Axonal regeneration was promoted in hydrogels carrying charged functional groups; hydrogels with positively charged functional groups showed increased axonal ingrowth into the central parts of the implant. Few astrocytes grew into the hydrogels. Our study shows that HEMA-based hydrogels carrying charged functional groups improve axonal ingrowth inside the implants compared to implants without any charge. Further, positively charged functional groups promote connective tissue infiltration and extended axonal regeneration inside a hydrogel bridge.</description><subject>Animals</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Biomaterials</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Biomedical materials</subject><subject>Ceramics</subject><subject>Chemistry and Materials Science</subject><subject>Composites</subject><subject>Glass</subject><subject>Guided Tissue Regeneration - methods</subject><subject>Hydrogels</subject><subject>Hydrogels - therapeutic use</subject><subject>Male</subject><subject>Materials Science</subject><subject>Materials Testing</subject><subject>Methacrylates - therapeutic use</subject><subject>Natural Materials</subject><subject>Nerve Regeneration</subject><subject>Nervous system</subject><subject>Polymer Sciences</subject><subject>Porosity</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Regenerative Medicine/Tissue Engineering</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Spinal Cord Injuries - therapy</subject><subject>Static Electricity</subject><subject>Surface Properties</subject><subject>Surfaces and Interfaces</subject><subject>Thin Films</subject><subject>Thoracic Vertebrae - injuries</subject><subject>Thoracic Vertebrae - pathology</subject><subject>Tissue engineering</subject><subject>Treatment Outcome</subject><issn>0957-4530</issn><issn>1573-4838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFUsuO1DAQtBCIHQY-gAuyOHDLYqf95IaWp7QIDnCOnKQzk5EnDnaybH6M78PzkBYhob243V1V3VJ3EfKcs0vOmH6dODNSFYzZAjQXhXhAVlxqKIQB85CsmJW6EBLYBXmS0o4xJqyUj8kFt6UsrTIr8vuLa2IYQwxzotuljWGDPtHaJWxpGGhZHIu3C07bxdN9DlmweDfhJf3m4kTVGwrv_pL-6qctHUPqp_4GqRtaOuDGHZM0x841SJutixtMR3AMfkGPzRTzZ8pY2I8ebzPaDzSN_eB8rsU2p7s5LjTi6Pr4lDzqnE_47BzX5MeH99-vPhXXXz9-vnp7XTQC-FQYyWxrLIKQTNRoAUBbpzoJtjFd2daldLUWToG1HWuxBq07hAYNa7jSFtbk1anvGMPPGdNU7fvUoPduwLyxSmkoQYO4lwgKSq2kuZdYcuCK5XdNXv5D3IU55nVkTsm50dYexvITKR8xpYhdNcZ-7-JScVYdPFKdPFJlj1QHj1QHzYtz47neY3unOJsiE8oTIWVo2GC8m_z_rn8A5o_KRA</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Hejcl, A</creator><creator>Lesný, P</creator><creator>Prádný, M</creator><creator>Sedý, J</creator><creator>Zámecník, J</creator><creator>Jendelová, P</creator><creator>Michálek, J</creator><creator>Syková, E</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0W</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Macroporous hydrogels based on 2-hydroxyethyl methacrylate. 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hejcl, A</au><au>Lesný, P</au><au>Prádný, M</au><au>Sedý, J</au><au>Zámecník, J</au><au>Jendelová, P</au><au>Michálek, J</au><au>Syková, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 6: 3D hydrogels with positive and negative surface charges and polyelectrolyte complexes in spinal cord injury repair</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><stitle>J Mater Sci: Mater Med</stitle><addtitle>J Mater Sci Mater Med</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>20</volume><issue>7</issue><spage>1571</spage><epage>1577</epage><pages>1571-1577</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Macroporous hydrogels are artificial biomaterials commonly used in tissue engineering, including central nervous system (CNS) repair. Their physical properties may be modified to improve their adhesion properties and promote tissue regeneration. We implanted four types of hydrogels based on 2-hydroxyethyl methacrylate (HEMA) with different surface charges inside a spinal cord hemisection cavity at the Th8 level in rats. The spinal cords were processed 1 and 6 months after implantation and histologically evaluated. Connective tissue deposition was most abundant in the hydrogels with positively-charged functional groups. Axonal regeneration was promoted in hydrogels carrying charged functional groups; hydrogels with positively charged functional groups showed increased axonal ingrowth into the central parts of the implant. Few astrocytes grew into the hydrogels. Our study shows that HEMA-based hydrogels carrying charged functional groups improve axonal ingrowth inside the implants compared to implants without any charge. Further, positively charged functional groups promote connective tissue infiltration and extended axonal regeneration inside a hydrogel bridge.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>19252968</pmid><doi>10.1007/s10856-009-3714-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Biocompatible Materials - therapeutic use Biomaterials Biomedical Engineering and Bioengineering Biomedical materials Ceramics Chemistry and Materials Science Composites Glass Guided Tissue Regeneration - methods Hydrogels Hydrogels - therapeutic use Male Materials Science Materials Testing Methacrylates - therapeutic use Natural Materials Nerve Regeneration Nervous system Polymer Sciences Porosity Rats Rats, Wistar Regenerative Medicine/Tissue Engineering Spinal Cord Injuries - pathology Spinal Cord Injuries - therapy Static Electricity Surface Properties Surfaces and Interfaces Thin Films Thoracic Vertebrae - injuries Thoracic Vertebrae - pathology Tissue engineering Treatment Outcome |
| title | Macroporous hydrogels based on 2-hydroxyethyl methacrylate. Part 6: 3D hydrogels with positive and negative surface charges and polyelectrolyte complexes in spinal cord injury repair |
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