Limited plasticity in T cell recognition of modified T cell receptor contact residues in MHC class II bound peptides

The balance between specific and degenerate T cell recognition of MHC class II bound peptides is crucial for T cell repertoire selection, and holds important implications for protective immunity versus autoimmunity. To investigate the degree of degeneracy in T cell recognition, we applied selected m...

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Veröffentlicht in:	Molecular Immunology 2005-02, Vol.42 (3), p.355-364
Hauptverfasser:	Haan, Ellen C. de, Wagenaar-Hilbers, Josée P.A., Liskamp, Rob M.J., Moret, Ed E., Wauben, Marca H.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - chemistry Animals Antibodies, Monoclonal - immunology Antigen presentation Autoimmunity Carbohydrates - chemistry Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Glycosylation Guinea Pigs Histocompatibility Antigens Class II - chemistry Histocompatibility Antigens Class II - metabolism Lymph Nodes - cytology Lymphocyte Activation - immunology Major histocompatibility complex Male MHC Molecular Structure Myelin Basic Protein - chemistry Myelin Basic Protein - immunology Myelin Basic Protein - metabolism Peptide Fragments - chemistry Peptide Fragments - immunology Peptide Fragments - metabolism Peptide modification Peptoids - immunology Rats Receptors, Antigen, T-Cell - immunology Specificity T cell receptor T-Lymphocytes - immunology T-Lymphocytes - metabolism TCR
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