Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion
In adults, bone marrow‐derived cells (BMDC) can contribute to the structure of various non‐haematopoietic tissues, including skin. However, the physiological importance of these cells is unclear. This study establishes that bone marrow‐derived epidermal cells are proliferative and, moreover, demonst...
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| Veröffentlicht in: | The Journal of pathology 2005-01, Vol.205 (1), p.1-13 |
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| container_title | The Journal of pathology |
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| creator | Brittan, Mairi Braun, Kristin M Reynolds, Louise E Conti, Francesco J Reynolds, Andrew R Poulsom, Richard Alison, Malcolm R Wright, Nicholas A Hodivala-Dilke, Kairbaan M |
| description | In adults, bone marrow‐derived cells (BMDC) can contribute to the structure of various non‐haematopoietic tissues, including skin. However, the physiological importance of these cells is unclear. This study establishes that bone marrow‐derived epidermal cells are proliferative and, moreover, demonstrates for the first time that BMDC can localize to a known stem cell niche: the CD34‐positive bulge region of mouse hair follicles. In addition, engraftment of bone marrow cells into the epidermis is significantly increased in wounded skin, bone marrow‐derived keratinocytes can form colonies in the regenerating epidermis in vivo, and the colony‐forming capacity of these cells can be recapitulated in vitro. In some tissues this apparent plasticity is attributed to differentiation, and in others to cell fusion. Evidence is also provided that bone marrow cells form epidermal keratinocytes without undergoing cell fusion. These data suggest a functional role for bone marrow cells in epidermal regeneration, entering known epidermal stem cell niches without heterokaryon formation. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/path.1682 |
| format | Article |
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However, the physiological importance of these cells is unclear. This study establishes that bone marrow‐derived epidermal cells are proliferative and, moreover, demonstrates for the first time that BMDC can localize to a known stem cell niche: the CD34‐positive bulge region of mouse hair follicles. In addition, engraftment of bone marrow cells into the epidermis is significantly increased in wounded skin, bone marrow‐derived keratinocytes can form colonies in the regenerating epidermis in vivo, and the colony‐forming capacity of these cells can be recapitulated in vitro. In some tissues this apparent plasticity is attributed to differentiation, and in others to cell fusion. Evidence is also provided that bone marrow cells form epidermal keratinocytes without undergoing cell fusion. These data suggest a functional role for bone marrow cells in epidermal regeneration, entering known epidermal stem cell niches without heterokaryon formation. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1682</identifier><identifier>PMID: 15546160</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; Biological and medical sciences ; bone marrow ; Bone Marrow Cells - pathology ; Bone Marrow Transplantation ; bone marrow-derived keratinocytes ; Cell Division ; Cell Fusion ; epidermal regeneration ; epidermal stem cell niche ; Epidermis - pathology ; Epidermis - physiology ; Female ; Investigative techniques, diagnostic techniques (general aspects) ; Keratinocytes - pathology ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Regeneration ; Skin - injuries ; Stem Cells - pathology ; Wound Healing</subject><ispartof>The Journal of pathology, 2005-01, Vol.205 (1), p.1-13</ispartof><rights>Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3912-7d1e9a80e7f87f01089782bf8747bbc7b991f5418815a7ffa4117bc936d505583</citedby><cites>FETCH-LOGICAL-c3912-7d1e9a80e7f87f01089782bf8747bbc7b991f5418815a7ffa4117bc936d505583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1682$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1682$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16360916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15546160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brittan, Mairi</creatorcontrib><creatorcontrib>Braun, Kristin M</creatorcontrib><creatorcontrib>Reynolds, Louise E</creatorcontrib><creatorcontrib>Conti, Francesco J</creatorcontrib><creatorcontrib>Reynolds, Andrew R</creatorcontrib><creatorcontrib>Poulsom, Richard</creatorcontrib><creatorcontrib>Alison, Malcolm R</creatorcontrib><creatorcontrib>Wright, Nicholas A</creatorcontrib><creatorcontrib>Hodivala-Dilke, Kairbaan M</creatorcontrib><title>Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>In adults, bone marrow‐derived cells (BMDC) can contribute to the structure of various non‐haematopoietic tissues, including skin. However, the physiological importance of these cells is unclear. This study establishes that bone marrow‐derived epidermal cells are proliferative and, moreover, demonstrates for the first time that BMDC can localize to a known stem cell niche: the CD34‐positive bulge region of mouse hair follicles. In addition, engraftment of bone marrow cells into the epidermis is significantly increased in wounded skin, bone marrow‐derived keratinocytes can form colonies in the regenerating epidermis in vivo, and the colony‐forming capacity of these cells can be recapitulated in vitro. In some tissues this apparent plasticity is attributed to differentiation, and in others to cell fusion. Evidence is also provided that bone marrow cells form epidermal keratinocytes without undergoing cell fusion. These data suggest a functional role for bone marrow cells in epidermal regeneration, entering known epidermal stem cell niches without heterokaryon formation. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>bone marrow</subject><subject>Bone Marrow Cells - pathology</subject><subject>Bone Marrow Transplantation</subject><subject>bone marrow-derived keratinocytes</subject><subject>Cell Division</subject><subject>Cell Fusion</subject><subject>epidermal regeneration</subject><subject>epidermal stem cell niche</subject><subject>Epidermis - pathology</subject><subject>Epidermis - physiology</subject><subject>Female</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Keratinocytes - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Regeneration</subject><subject>Skin - injuries</subject><subject>Stem Cells - pathology</subject><subject>Wound Healing</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhq0KRLcLh_4B5AtIPaS1k_jrWCr6gVYtEkU9Wk4yZg1Ze7Gzu-2_r9ON6ImLR9Y88847L0LHlJxSQsqztRmWp5TL8gDNKFG8UFLxN2iWe2VR1VQcoqOUfhNClGLsHTqkjNWccjJD9kvwgFcmxrDDLfR9wuB_RWMHvHPD0nk8LAHD2nUQVy5h4zu8jqF3FqIZAGdg67bhBcY-YNhm0reAg32Rw3aTXPDv0Vtr-gQfpjpHPy-_3l9cF4u7q5uL80XRVoqWhegoKCMJCCuFJZRIJWTZ5E8tmqYVjVLUsppKSZkR1pqaUtG0quIdI4zJao4-73Wzx78bSIPOpkcfxkPYJM1FVZaCqgye7ME2hpQiWL2OLsfwpCnRY6h6DFWPoWb24yS6aVbQvZJTihn4NAEmtaa30fjWpVeOV5yo_M7R2Z7buR6e_r9Rfz-_v55WF_sJlwZ4_Ddh4p_xFMH0w-2Vflj8kN_qqtZl9QzPj51h</recordid><startdate>200501</startdate><enddate>200501</enddate><creator>Brittan, Mairi</creator><creator>Braun, Kristin M</creator><creator>Reynolds, Louise E</creator><creator>Conti, Francesco J</creator><creator>Reynolds, Andrew R</creator><creator>Poulsom, Richard</creator><creator>Alison, Malcolm R</creator><creator>Wright, Nicholas A</creator><creator>Hodivala-Dilke, Kairbaan M</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200501</creationdate><title>Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion</title><author>Brittan, Mairi ; Braun, Kristin M ; Reynolds, Louise E ; Conti, Francesco J ; Reynolds, Andrew R ; Poulsom, Richard ; Alison, Malcolm R ; Wright, Nicholas A ; Hodivala-Dilke, Kairbaan M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3912-7d1e9a80e7f87f01089782bf8747bbc7b991f5418815a7ffa4117bc936d505583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>bone marrow</topic><topic>Bone Marrow Cells - pathology</topic><topic>Bone Marrow Transplantation</topic><topic>bone marrow-derived keratinocytes</topic><topic>Cell Division</topic><topic>Cell Fusion</topic><topic>epidermal regeneration</topic><topic>epidermal stem cell niche</topic><topic>Epidermis - pathology</topic><topic>Epidermis - physiology</topic><topic>Female</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Keratinocytes - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Regeneration</topic><topic>Skin - injuries</topic><topic>Stem Cells - pathology</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brittan, Mairi</creatorcontrib><creatorcontrib>Braun, Kristin M</creatorcontrib><creatorcontrib>Reynolds, Louise E</creatorcontrib><creatorcontrib>Conti, Francesco J</creatorcontrib><creatorcontrib>Reynolds, Andrew R</creatorcontrib><creatorcontrib>Poulsom, Richard</creatorcontrib><creatorcontrib>Alison, Malcolm R</creatorcontrib><creatorcontrib>Wright, Nicholas A</creatorcontrib><creatorcontrib>Hodivala-Dilke, Kairbaan M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brittan, Mairi</au><au>Braun, Kristin M</au><au>Reynolds, Louise E</au><au>Conti, Francesco J</au><au>Reynolds, Andrew R</au><au>Poulsom, Richard</au><au>Alison, Malcolm R</au><au>Wright, Nicholas A</au><au>Hodivala-Dilke, Kairbaan M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>2005-01</date><risdate>2005</risdate><volume>205</volume><issue>1</issue><spage>1</spage><epage>13</epage><pages>1-13</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>In adults, bone marrow‐derived cells (BMDC) can contribute to the structure of various non‐haematopoietic tissues, including skin. However, the physiological importance of these cells is unclear. This study establishes that bone marrow‐derived epidermal cells are proliferative and, moreover, demonstrates for the first time that BMDC can localize to a known stem cell niche: the CD34‐positive bulge region of mouse hair follicles. In addition, engraftment of bone marrow cells into the epidermis is significantly increased in wounded skin, bone marrow‐derived keratinocytes can form colonies in the regenerating epidermis in vivo, and the colony‐forming capacity of these cells can be recapitulated in vitro. In some tissues this apparent plasticity is attributed to differentiation, and in others to cell fusion. Evidence is also provided that bone marrow cells form epidermal keratinocytes without undergoing cell fusion. These data suggest a functional role for bone marrow cells in epidermal regeneration, entering known epidermal stem cell niches without heterokaryon formation. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>15546160</pmid><doi>10.1002/path.1682</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences bone marrow Bone Marrow Cells - pathology Bone Marrow Transplantation bone marrow-derived keratinocytes Cell Division Cell Fusion epidermal regeneration epidermal stem cell niche Epidermis - pathology Epidermis - physiology Female Investigative techniques, diagnostic techniques (general aspects) Keratinocytes - pathology Male Medical sciences Mice Mice, Inbred C57BL Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Regeneration Skin - injuries Stem Cells - pathology Wound Healing |
| title | Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion |
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