Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates

The pH-dependent binding of Igs to the neonatal FcR (FcRn) plays a critical role in the in vivo homeostasis of IgGs. Modulating the interaction between Fc and FcRn through protein engineering is one method for improving the pharmacokinetics of therapeutic Abs. Recent studies disputed the direct rela...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-06, Vol.182 (12), p.7663-7671
Hauptverfasser:	Yeung, Yik Andy, Leabman, Maya K, Marvin, Jonathan S, Qiu, Julia, Adams, Camellia W, Lien, Samantha, Starovasnik, Melissa A, Lowman, Henry B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibody Affinity - immunology Histocompatibility Antigens Class I - immunology Humans Hydrogen-Ion Concentration Immunoglobulin G - genetics Immunoglobulin G - immunology Immunoglobulin G - metabolism Immunoglobulin G - pharmacology Macaca fascicularis - immunology Mice Models, Molecular Mutation - genetics Protein Structure, Quaternary Receptors, Fc - immunology Recombinant Proteins - genetics Recombinant Proteins - immunology Recombinant Proteins - metabolism Recombinant Proteins - pharmacology
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