The action of the mast cell product tryptase on cyclooxygenase-2 (COX2) and subsequent fibroblast proliferation involves activation of the extracellular signal-regulated kinase isoforms 1 and 2 (erk1/2)

The mast cell product tryptase, via protease-activated receptor 2 (PAR2), induces cyclooxygenase-2 (COX2) and 15-deoxy-prostaglandin J2 (15d-PGJ2) synthesis. 15d-PGJ2, through the nuclear peroxisome proliferator activated receptor gamma (PPARγ), subsequently causes fibroblast proliferation. In this...

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Veröffentlicht in:	Cellular signalling 2005-04, Vol.17 (4), p.525-533
Hauptverfasser:	Frungieri, Mónica B., Albrecht, Martin, Raemsch, Romi, Mayerhofer, Artur
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Ca 2 Calcium - metabolism cAMP Cell Proliferation Cyclic AMP - metabolism Cyclooxygenase 2 Fibroblasts - cytology Fibroblasts - enzymology Human immunodeficiency virus 2 Humans Male MAP kinases Mast Cells - enzymology Membrane Proteins Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Molecular Sequence Data Prostaglandin-Endoperoxide Synthases - metabolism Protein Isoforms - metabolism Serine Endopeptidases - metabolism Signal Transduction Transcription factors Tryptase Tryptases Up-Regulation
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