LysK CHAP endopeptidase domain is required for lysis of live staphylococcal cells

LysK is a staphylococcal bacteriophage endolysin composed of three domains: an N-terminal cysteine, histidine-dependent amidohydrolases/peptidases (CHAP) endopeptidase domain, a midprotein amidase 2 domain, and a C-terminal SH3b_5 (SH3b) cell wall-binding domain. Both catalytic domains are active on...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	FEMS microbiology letters 2009-05, Vol.294 (1), p.52-60
Hauptverfasser:	Becker, Stephen C, Dong, Shengli, Baker, John R, Foster-Frey, Juli, Pritchard, David G, Donovan, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amidase animal pathogenic bacteria Anti-Bacterial Agents - metabolism Assaying autolysin Bacteriolysis bacteriophage endolysin bacteriophages Binding Cell walls Coagulase coagulase-negative Staphylococcus D-Alanine Domains Endopeptidases Endopeptidases - genetics Endopeptidases - metabolism enzyme activity Glycine Histidine Ionization L-Alanine Lysis LysK Lysostaphin Lysostaphin - metabolism Microbial Sensitivity Tests Microbial Viability Microbiology Minimum inhibitory concentration N-Acetylmuramoyl-L-alanine amidase Peptidases Peptides peptidoglycan peptidoglycan hydrolase Peptidoglycans proteinases Reduction Sequence Deletion Staphylococcus Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - virology Staphylococcus Phages - enzymology Turbidity viral proteins Viral Proteins - genetics Viral Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!