Prognostic value of computed tomography coronary angiography in patients with suspected coronary artery disease: a 24-month follow-up study
The aim of this study was to determine the predictive value of 64-slice computed tomography coronary angiography (CTCA) for major cardiac events in patients with suspected coronary artery disease (CAD). A total of 187 consecutive patients (119 men, age 62.5 ± 10.5 years) without known heart disease...
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| Veröffentlicht in: | European radiology 2009-07, Vol.19 (7), p.1653-1660 |
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| creator | Aldrovandi, Annachiara Maffei, Erica Palumbo, Alessandro Seitun, Sara Martini, Chiara Brambilla, Valerio Zuccarelli, Alessandra Tarantini, Giuseppe Weustink, Annick C. Mollet, Nico R. Ruffini, Livia Crisi, Girolamo Ardissino, Diego de Feyter, Pim J. Krestin, Gabriel P. Cademartiri, Filippo |
| description | The aim of this study was to determine the predictive value of 64-slice computed tomography coronary angiography (CTCA) for major cardiac events in patients with suspected coronary artery disease (CAD). A total of 187 consecutive patients (119 men, age 62.5 ± 10.5 years) without known heart disease underwent single-source 64-slice CTCA (Somatom Sensation 64, Siemens) for clinical suspicion of CAD. Patients underwent follow-up for the occurrence of cardiac death, nonfatal myocardial infarction, unstable angina and cardiac revascularization. In total, 2,822 coronary segments were assessed. Forty-two segments (1.5%) were not assessable because of insufficient image quality. Overall, CTCA revealed absence of CAD in 65 (34.7%) patients, nonobstructive CAD (coronary plaque ≤50%) in 87 (46.5%) patients and obstructive CAD (>50%) in 35 (18.8%) patients. A total of 20 major cardiac events (3 myocardial infarctions, 16 cardiac revascularizations, 1 unstable angina) occurred during a mean follow-up of 24 months. One noncardiac death occurred. Seventeen events occurred in the group of patients with obstructive CAD and three events occurred in the group of nonobstructive CAD. The event rate was 0% among patients with normal coronary arteries at CTCA. CTCA has a 100% negative predictive value for major cardiac events at 24-month follow-up in patients with normal coronary arteries. |
| doi_str_mv | 10.1007/s00330-009-1344-3 |
| format | Article |
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A total of 187 consecutive patients (119 men, age 62.5 ± 10.5 years) without known heart disease underwent single-source 64-slice CTCA (Somatom Sensation 64, Siemens) for clinical suspicion of CAD. Patients underwent follow-up for the occurrence of cardiac death, nonfatal myocardial infarction, unstable angina and cardiac revascularization. In total, 2,822 coronary segments were assessed. Forty-two segments (1.5%) were not assessable because of insufficient image quality. Overall, CTCA revealed absence of CAD in 65 (34.7%) patients, nonobstructive CAD (coronary plaque ≤50%) in 87 (46.5%) patients and obstructive CAD (>50%) in 35 (18.8%) patients. A total of 20 major cardiac events (3 myocardial infarctions, 16 cardiac revascularizations, 1 unstable angina) occurred during a mean follow-up of 24 months. One noncardiac death occurred. Seventeen events occurred in the group of patients with obstructive CAD and three events occurred in the group of nonobstructive CAD. The event rate was 0% among patients with normal coronary arteries at CTCA. CTCA has a 100% negative predictive value for major cardiac events at 24-month follow-up in patients with normal coronary arteries.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-009-1344-3</identifier><identifier>PMID: 19224218</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Aged ; Angina pectoris ; Blood pressure ; Cardiac ; Cardiology ; Cardiovascular disease ; Coronary Angiography - statistics & numerical data ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - mortality ; Coronary vessels ; Diagnostic Radiology ; Dyspnea ; Female ; Follow-Up Studies ; Heart attacks ; Humans ; Imaging ; Incidence ; Internal Medicine ; Interventional Radiology ; Italy - epidemiology ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroradiology ; Patients ; Pharmacists ; Prognosis ; Radiology ; Reproducibility of Results ; Sensitivity and Specificity ; Survival Analysis ; Survival Rate ; Tomography ; Tomography, X-Ray Computed - statistics & numerical data ; Ultrasound ; Vein & artery diseases</subject><ispartof>European radiology, 2009-07, Vol.19 (7), p.1653-1660</ispartof><rights>European Society of Radiology 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-59cabd7dbd84ff23446927158212942bfdca659b74ab85d2e29c1ad5ed604fc73</citedby><cites>FETCH-LOGICAL-c400t-59cabd7dbd84ff23446927158212942bfdca659b74ab85d2e29c1ad5ed604fc73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-009-1344-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-009-1344-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19224218$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aldrovandi, Annachiara</creatorcontrib><creatorcontrib>Maffei, Erica</creatorcontrib><creatorcontrib>Palumbo, Alessandro</creatorcontrib><creatorcontrib>Seitun, Sara</creatorcontrib><creatorcontrib>Martini, Chiara</creatorcontrib><creatorcontrib>Brambilla, Valerio</creatorcontrib><creatorcontrib>Zuccarelli, Alessandra</creatorcontrib><creatorcontrib>Tarantini, Giuseppe</creatorcontrib><creatorcontrib>Weustink, Annick C.</creatorcontrib><creatorcontrib>Mollet, Nico R.</creatorcontrib><creatorcontrib>Ruffini, Livia</creatorcontrib><creatorcontrib>Crisi, Girolamo</creatorcontrib><creatorcontrib>Ardissino, Diego</creatorcontrib><creatorcontrib>de Feyter, Pim J.</creatorcontrib><creatorcontrib>Krestin, Gabriel P.</creatorcontrib><creatorcontrib>Cademartiri, Filippo</creatorcontrib><title>Prognostic value of computed tomography coronary angiography in patients with suspected coronary artery disease: a 24-month follow-up study</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>The aim of this study was to determine the predictive value of 64-slice computed tomography coronary angiography (CTCA) for major cardiac events in patients with suspected coronary artery disease (CAD). A total of 187 consecutive patients (119 men, age 62.5 ± 10.5 years) without known heart disease underwent single-source 64-slice CTCA (Somatom Sensation 64, Siemens) for clinical suspicion of CAD. Patients underwent follow-up for the occurrence of cardiac death, nonfatal myocardial infarction, unstable angina and cardiac revascularization. In total, 2,822 coronary segments were assessed. Forty-two segments (1.5%) were not assessable because of insufficient image quality. Overall, CTCA revealed absence of CAD in 65 (34.7%) patients, nonobstructive CAD (coronary plaque ≤50%) in 87 (46.5%) patients and obstructive CAD (>50%) in 35 (18.8%) patients. A total of 20 major cardiac events (3 myocardial infarctions, 16 cardiac revascularizations, 1 unstable angina) occurred during a mean follow-up of 24 months. One noncardiac death occurred. Seventeen events occurred in the group of patients with obstructive CAD and three events occurred in the group of nonobstructive CAD. The event rate was 0% among patients with normal coronary arteries at CTCA. CTCA has a 100% negative predictive value for major cardiac events at 24-month follow-up in patients with normal coronary arteries.</description><subject>Aged</subject><subject>Angina pectoris</subject><subject>Blood pressure</subject><subject>Cardiac</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Coronary Angiography - statistics & numerical data</subject><subject>Coronary Artery Disease - diagnostic imaging</subject><subject>Coronary Artery Disease - mortality</subject><subject>Coronary vessels</subject><subject>Diagnostic Radiology</subject><subject>Dyspnea</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Imaging</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Patients</subject><subject>Pharmacists</subject><subject>Prognosis</subject><subject>Radiology</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Tomography</subject><subject>Tomography, X-Ray Computed - 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Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aldrovandi, Annachiara</au><au>Maffei, Erica</au><au>Palumbo, Alessandro</au><au>Seitun, Sara</au><au>Martini, Chiara</au><au>Brambilla, Valerio</au><au>Zuccarelli, Alessandra</au><au>Tarantini, Giuseppe</au><au>Weustink, Annick C.</au><au>Mollet, Nico R.</au><au>Ruffini, Livia</au><au>Crisi, Girolamo</au><au>Ardissino, Diego</au><au>de Feyter, Pim J.</au><au>Krestin, Gabriel P.</au><au>Cademartiri, Filippo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of computed tomography coronary angiography in patients with suspected coronary artery disease: a 24-month follow-up study</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>19</volume><issue>7</issue><spage>1653</spage><epage>1660</epage><pages>1653-1660</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>The aim of this study was to determine the predictive value of 64-slice computed tomography coronary angiography (CTCA) for major cardiac events in patients with suspected coronary artery disease (CAD). A total of 187 consecutive patients (119 men, age 62.5 ± 10.5 years) without known heart disease underwent single-source 64-slice CTCA (Somatom Sensation 64, Siemens) for clinical suspicion of CAD. Patients underwent follow-up for the occurrence of cardiac death, nonfatal myocardial infarction, unstable angina and cardiac revascularization. In total, 2,822 coronary segments were assessed. Forty-two segments (1.5%) were not assessable because of insufficient image quality. Overall, CTCA revealed absence of CAD in 65 (34.7%) patients, nonobstructive CAD (coronary plaque ≤50%) in 87 (46.5%) patients and obstructive CAD (>50%) in 35 (18.8%) patients. A total of 20 major cardiac events (3 myocardial infarctions, 16 cardiac revascularizations, 1 unstable angina) occurred during a mean follow-up of 24 months. One noncardiac death occurred. Seventeen events occurred in the group of patients with obstructive CAD and three events occurred in the group of nonobstructive CAD. The event rate was 0% among patients with normal coronary arteries at CTCA. CTCA has a 100% negative predictive value for major cardiac events at 24-month follow-up in patients with normal coronary arteries.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19224218</pmid><doi>10.1007/s00330-009-1344-3</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Angina pectoris Blood pressure Cardiac Cardiology Cardiovascular disease Coronary Angiography - statistics & numerical data Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - mortality Coronary vessels Diagnostic Radiology Dyspnea Female Follow-Up Studies Heart attacks Humans Imaging Incidence Internal Medicine Interventional Radiology Italy - epidemiology Male Medical imaging Medicine Medicine & Public Health Middle Aged Neuroradiology Patients Pharmacists Prognosis Radiology Reproducibility of Results Sensitivity and Specificity Survival Analysis Survival Rate Tomography Tomography, X-Ray Computed - statistics & numerical data Ultrasound Vein & artery diseases |
| title | Prognostic value of computed tomography coronary angiography in patients with suspected coronary artery disease: a 24-month follow-up study |
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