MYC-Dependent Regulation and Prognostic Role of CIP2A in Gastric Cancer

Background Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified human oncoprotein that stabilizes the c-Myc (MYC) protein. However, the clinical relevance of CIP2A to human cancers had not been demonstrated, but the mechanism of its regulation and its clinical role in cance...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2009-06, Vol.101 (11), p.793-805
Hauptverfasser:	Khanna, Anchit, Böckelman, Camilla, Hemmes, Annabrita, Junttila, Melissa R., Wiksten, Jan-Patrik, Lundin, Mikael, Junnila, Siina, Murphy, Daniel J., Evan, Gerard I., Haglund, Caj, Westermarck, Jukka, Ristimäki, Ari
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemistry Adenocarcinoma - mortality Autoantigens - analysis Autoantigens - genetics Autoantigens - immunology Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Biomarkers, Tumor - immunology Cancer Cell Cycle Cell Line, Tumor Cell Proliferation Down-Regulation Feedback, Physiological Finland Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal diseases Gene expression Gene Expression Regulation, Neoplastic Humans Immunoblotting Immunohistochemistry Kaplan-Meier Estimate Medical prognosis Medical sciences Membrane Proteins - analysis Membrane Proteins - genetics Membrane Proteins - immunology Oncology Predictive Value of Tests Prognosis Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - immunology Proto-Oncogene Proteins c-myc - metabolism Registries Retrospective Studies RNA, Messenger - analysis RNA, Small Interfering - analysis Stomach Neoplasms - chemistry Stomach Neoplasms - mortality Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tissue Array Analysis Tumors
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