Preparation and characterization of solid lipid nanoparticles loaded with doxorubicin

Solid lipid nanoparticles (SLN) loaded with doxorubicin were prepared by solvent emulsification-diffusion method. Glyceryl caprate (Capmul ®MCM C10) was used as lipid core, and curdlan as the shell material. Dimethyl sulfoxide (DMSO) was used to dissolve both lipid and drug. Polyethylene glycol 660...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2009-06, Vol.37 (3), p.508-513
Hauptverfasser:	Subedi, Robhash Kusam, Kang, Keon Wook, Choi, Hoo-Kyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - pharmacology beta-Glucans - chemistry Biological and medical sciences Calorimetry, Differential Scanning Cell Line, Tumor Cell Survival - drug effects Curdlan Dialysis Dimethyl Sulfoxide Doxorubicin Doxorubicin - administration & dosage Doxorubicin - chemistry Doxorubicin - pharmacology Drug Compounding Drug delivery Drug Delivery Systems Drug Stability Female Freeze Drying General pharmacology Glyceryl caprate Humans Lipids - chemistry Medical sciences Nanoparticles Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solid lipid nanoparticles Solubility Solvents Spectrometry, Fluorescence
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