HDL cholesterol and cardiovascular disease in a population with hypertension and type 2 diabetes mellitus. RICARHD Study
To assess the prevalence of low serum levels of HDL cholesterol (HDL-C) and its relationship with the presence of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (DM) and arterial hypertension attended in Internal Medicine and Nephrology offices. Cross-sectional, multicenter s...
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| Veröffentlicht in: | Revista clínica espanõla 2009-05, Vol.209 (5), p.227-233 |
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| creator | Conthe, P Gómez-Fernández, P de Alvaro, F Fernández-Pérez, C González-Esteban, J Cea-Calvo, L |
| description | To assess the prevalence of low serum levels of HDL cholesterol (HDL-C) and its relationship with the presence of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (DM) and arterial hypertension attended in Internal Medicine and Nephrology offices.
Cross-sectional, multicenter study, conducted in diabetic patients with hypertension, aged >/= 55 years old. Demographic, clinical and biochemical data were obtained from the patient's hospital records. Low HDL-C was defined as |
| doi_str_mv | 10.1016/S0014-2565(09)71239-1 |
| format | Article |
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Cross-sectional, multicenter study, conducted in diabetic patients with hypertension, aged >/= 55 years old. Demographic, clinical and biochemical data were obtained from the patient's hospital records. Low HDL-C was defined as <40 mg/dl (men) or <46 mg/dl (women). The relationship between low HDL-C and CVD was assessed using logistic regression models.
In 2,021 patients (mean age: 68.6 years, 48.9% women, 51.1% with established CVD), the prevalence of low HDL-C was 33.7% (95% CI: 31.5-35.7), it being higher in women (38.0%) than in men (29.6%, p<0.001), and higher in patients with previous CVD (37.3% vs. 29.9% in patients without CVD, p=0.001). In the multivariate analysis that included cardiovascular risk factors, an independent relationship between low HDL-C levels and CVD was observed (OR for CVD in patients with low HDL-C: 1.46 [CI 95%: 1.19-1.79, p<0.001]), compared to patients with normal HDL-C blood levels. A second model which was also adjusted for left ventricular hypertrophy and renal disease showed a similar association (OR 1.55 [1.21-2.00], p=0.001). This association was stronger in women than in men.
One out of three patients with diabetes and hypertension examined in Internal Medicine and Nephrology outpatient offices had low serum levels of HDL-C. Low HDL-C showed an independent relationship with a higher prevalence of CVD.</description><identifier>ISSN: 0014-2565</identifier><identifier>DOI: 10.1016/S0014-2565(09)71239-1</identifier><identifier>PMID: 19480779</identifier><language>spa</language><publisher>Spain</publisher><subject>Aged ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - epidemiology ; Cholesterol, HDL - blood ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Female ; Humans ; Hypertension - blood ; Hypertension - complications ; Male</subject><ispartof>Revista clínica espanõla, 2009-05, Vol.209 (5), p.227-233</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19480779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conthe, P</creatorcontrib><creatorcontrib>Gómez-Fernández, P</creatorcontrib><creatorcontrib>de Alvaro, F</creatorcontrib><creatorcontrib>Fernández-Pérez, C</creatorcontrib><creatorcontrib>González-Esteban, J</creatorcontrib><creatorcontrib>Cea-Calvo, L</creatorcontrib><creatorcontrib>Investigadores del estudio RICARHD</creatorcontrib><title>HDL cholesterol and cardiovascular disease in a population with hypertension and type 2 diabetes mellitus. RICARHD Study</title><title>Revista clínica espanõla</title><addtitle>Rev Clin Esp</addtitle><description>To assess the prevalence of low serum levels of HDL cholesterol (HDL-C) and its relationship with the presence of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (DM) and arterial hypertension attended in Internal Medicine and Nephrology offices.
Cross-sectional, multicenter study, conducted in diabetic patients with hypertension, aged >/= 55 years old. Demographic, clinical and biochemical data were obtained from the patient's hospital records. Low HDL-C was defined as <40 mg/dl (men) or <46 mg/dl (women). The relationship between low HDL-C and CVD was assessed using logistic regression models.
In 2,021 patients (mean age: 68.6 years, 48.9% women, 51.1% with established CVD), the prevalence of low HDL-C was 33.7% (95% CI: 31.5-35.7), it being higher in women (38.0%) than in men (29.6%, p<0.001), and higher in patients with previous CVD (37.3% vs. 29.9% in patients without CVD, p=0.001). In the multivariate analysis that included cardiovascular risk factors, an independent relationship between low HDL-C levels and CVD was observed (OR for CVD in patients with low HDL-C: 1.46 [CI 95%: 1.19-1.79, p<0.001]), compared to patients with normal HDL-C blood levels. A second model which was also adjusted for left ventricular hypertrophy and renal disease showed a similar association (OR 1.55 [1.21-2.00], p=0.001). This association was stronger in women than in men.
One out of three patients with diabetes and hypertension examined in Internal Medicine and Nephrology outpatient offices had low serum levels of HDL-C. Low HDL-C showed an independent relationship with a higher prevalence of CVD.</description><subject>Aged</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cholesterol, HDL - blood</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - complications</subject><subject>Male</subject><issn>0014-2565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRb0A0VL4BJBXCBYBO47jZIlaoEiVkFpYRxN7ohrlRewA_XtcUVhd6ejc0cwQcsHZLWc8vdswxpMolqm8ZvmN4rHII35Epv94Qk6de2csloKLEzLheZIxpfIp-V4uVlRvuxqdx6GrKbSGahiM7T7B6bGGgRrrEBxS21KgfdcH6G3X0i_rt3S763Hw2Lo92Zd9ADQOJSjRo6MN1rX1o7ul6-f5_Xq5oBs_mt0ZOa6gdnh-yBl5e3x4nS-j1ctT8FZRz0XuI1NmmdBSG0glMpUklQaV8VxwqFClIhGgQWKsOQNhjMgqJlXIKs1ZWZaZmJGr37n90H2M4cqisU6HnaDFbnRFqgRPMxYH8fIgjmWDpugH28CwK_5-JX4A4VxsMA</recordid><startdate>200905</startdate><enddate>200905</enddate><creator>Conthe, P</creator><creator>Gómez-Fernández, P</creator><creator>de Alvaro, F</creator><creator>Fernández-Pérez, C</creator><creator>González-Esteban, J</creator><creator>Cea-Calvo, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200905</creationdate><title>HDL cholesterol and cardiovascular disease in a population with hypertension and type 2 diabetes mellitus. RICARHD Study</title><author>Conthe, P ; Gómez-Fernández, P ; de Alvaro, F ; Fernández-Pérez, C ; González-Esteban, J ; Cea-Calvo, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p139t-db883c5cda65e0744fca781931afe76343aca5e2c10a3dd38f057dd3f690bbb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>spa</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cholesterol, HDL - blood</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - complications</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conthe, P</creatorcontrib><creatorcontrib>Gómez-Fernández, P</creatorcontrib><creatorcontrib>de Alvaro, F</creatorcontrib><creatorcontrib>Fernández-Pérez, C</creatorcontrib><creatorcontrib>González-Esteban, J</creatorcontrib><creatorcontrib>Cea-Calvo, L</creatorcontrib><creatorcontrib>Investigadores del estudio RICARHD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista clínica espanõla</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conthe, P</au><au>Gómez-Fernández, P</au><au>de Alvaro, F</au><au>Fernández-Pérez, C</au><au>González-Esteban, J</au><au>Cea-Calvo, L</au><aucorp>Investigadores del estudio RICARHD</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HDL cholesterol and cardiovascular disease in a population with hypertension and type 2 diabetes mellitus. RICARHD Study</atitle><jtitle>Revista clínica espanõla</jtitle><addtitle>Rev Clin Esp</addtitle><date>2009-05</date><risdate>2009</risdate><volume>209</volume><issue>5</issue><spage>227</spage><epage>233</epage><pages>227-233</pages><issn>0014-2565</issn><abstract>To assess the prevalence of low serum levels of HDL cholesterol (HDL-C) and its relationship with the presence of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (DM) and arterial hypertension attended in Internal Medicine and Nephrology offices.
Cross-sectional, multicenter study, conducted in diabetic patients with hypertension, aged >/= 55 years old. Demographic, clinical and biochemical data were obtained from the patient's hospital records. Low HDL-C was defined as <40 mg/dl (men) or <46 mg/dl (women). The relationship between low HDL-C and CVD was assessed using logistic regression models.
In 2,021 patients (mean age: 68.6 years, 48.9% women, 51.1% with established CVD), the prevalence of low HDL-C was 33.7% (95% CI: 31.5-35.7), it being higher in women (38.0%) than in men (29.6%, p<0.001), and higher in patients with previous CVD (37.3% vs. 29.9% in patients without CVD, p=0.001). In the multivariate analysis that included cardiovascular risk factors, an independent relationship between low HDL-C levels and CVD was observed (OR for CVD in patients with low HDL-C: 1.46 [CI 95%: 1.19-1.79, p<0.001]), compared to patients with normal HDL-C blood levels. A second model which was also adjusted for left ventricular hypertrophy and renal disease showed a similar association (OR 1.55 [1.21-2.00], p=0.001). This association was stronger in women than in men.
One out of three patients with diabetes and hypertension examined in Internal Medicine and Nephrology outpatient offices had low serum levels of HDL-C. Low HDL-C showed an independent relationship with a higher prevalence of CVD.</abstract><cop>Spain</cop><pmid>19480779</pmid><doi>10.1016/S0014-2565(09)71239-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Cardiovascular Diseases - blood Cardiovascular Diseases - complications Cardiovascular Diseases - epidemiology Cholesterol, HDL - blood Cross-Sectional Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Female Humans Hypertension - blood Hypertension - complications Male |
| title | HDL cholesterol and cardiovascular disease in a population with hypertension and type 2 diabetes mellitus. RICARHD Study |
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