Positional Scanning for Peptide Secondary Structure by Systematic Solid-Phase Synthesis of Amino Lactam Peptides

Incorporation of amino lactams into biologically active peptides has been commonly used to restrict conformational mobility, enhance selectivity, and increase potency. A solid-phase method using a Fmoc-protection strategy has been developed for the systematic synthesis of peptides containing configu...

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Veröffentlicht in:	Journal of the American Chemical Society 2009-06, Vol.131 (22), p.7917-7927
Hauptverfasser:	Jamieson, Andrew G, Boutard, Nicolas, Beauregard, Kim, Bodas, Mandar S, Ong, Huy, Quiniou, Christiane, Chemtob, Sylvain, Lubell, William D
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Fluorenes - chemistry Lactams - chemical synthesis Lactams - chemistry Oligopeptides - chemistry Peptides - chemical synthesis Peptides - chemistry Protein Structure, Secondary Receptors, Interleukin-1 - chemistry Stereoisomerism Sulfonamides - chemistry
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