Novel polymeric film coatings for colon targeting: Drug release from coated pellets

The aim of this study was to prepare and characterize novel types of polymer coated pellets allowing for the site-specific delivery of drugs to the colon. 5-Aminosalicylic acid (5-ASA)-loaded beads were prepared by extrusion–spheronization and coated with different Nutriose:ethylcellulose blends. In...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2009-06, Vol.37 (3), p.427-433
Hauptverfasser:	Karrout, Youness, Neut, Christel, Wils, Daniel, Siepmann, Florence, Deremaux, Laëtitia, Flament, Marie-Pierre, Dubreuil, Luc, Desreumaux, Pierre, Siepmann, Juergen
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Biological and medical sciences Capsules Cellulose - analogs & derivatives Colon - metabolism Colon targeting Delayed-Action Preparations Drug Delivery Systems Ethylcellulose Excipients - chemistry Feces - chemistry Film coating Gastrointestinal Tract - metabolism General pharmacology Humans Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - metabolism Medical sciences Mesalamine - administration & dosage Mesalamine - chemistry Pellets Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers - chemistry Tablets, Enteric-Coated
Online-Zugang:	Volltext
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