Conversion to dementia in mild cognitive impairment is associated with decline of N -actylaspartate and creatine as revealed by magnetic resonance spectroscopy
Abstract The purpose of the present study was to longitudinally track changes of metabolite markers detectable by magnetic resonance spectroscopy (MRS) in subjects with mild cognitive impairment (MCI) and to analyze these changes with respect to the rate of cognitive decline and clinical disease pro...
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| Veröffentlicht in: | Psychiatry research. Neuroimaging 2009-07, Vol.173 (1), p.1-7 |
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| creator | Pilatus, Ulrich Lais, Christoph Rochmont, Anna du Mesnil de Kratzsch, Tillmann Frölich, Lutz Maurer, Konrad Zanella, Friedhelm E Lanfermann, Heinrich Pantel, Johannes |
| description | Abstract The purpose of the present study was to longitudinally track changes of metabolite markers detectable by magnetic resonance spectroscopy (MRS) in subjects with mild cognitive impairment (MCI) and to analyze these changes with respect to the rate of cognitive decline and clinical disease progression. Fifteen subjects with MCI and 12 healthy elderly controls were investigated longitudinally (average follow-up period: 3.4 years) using absolute quantification of metabolites within the mid-parietal grey matter and the parietal white matter [ N -acetylaspartate (NAA), myo -inositol, choline, creatine, glutamine)] Our main findings include that a longitudinal decline in cognitive function (particularly in memory function) within the MCI group was predicted by a decline in absolute concentrations of the metabolic markers NAA and creatine. This effect was mainly explained by a significant decrease of NAA and creatine in those MCI subjects who converted to Alzheimer's dementia (AD) during the follow-up period. No differences were found at baseline between MCI converters and stable subjects, indicating that at least in the present study MRS did provide a predictive discrimination between converters and stable subjects. Our findings support the use of MRS as a tool for objectively monitoring disease progression even during the earliest stages of AD. |
| doi_str_mv | 10.1016/j.pscychresns.2008.07.015 |
| format | Article |
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Fifteen subjects with MCI and 12 healthy elderly controls were investigated longitudinally (average follow-up period: 3.4 years) using absolute quantification of metabolites within the mid-parietal grey matter and the parietal white matter [ N -acetylaspartate (NAA), myo -inositol, choline, creatine, glutamine)] Our main findings include that a longitudinal decline in cognitive function (particularly in memory function) within the MCI group was predicted by a decline in absolute concentrations of the metabolic markers NAA and creatine. This effect was mainly explained by a significant decrease of NAA and creatine in those MCI subjects who converted to Alzheimer's dementia (AD) during the follow-up period. No differences were found at baseline between MCI converters and stable subjects, indicating that at least in the present study MRS did provide a predictive discrimination between converters and stable subjects. Our findings support the use of MRS as a tool for objectively monitoring disease progression even during the earliest stages of AD.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2008.07.015</identifier><identifier>PMID: 19427767</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aged ; Alzheimer Disease - metabolism ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Biological and medical sciences ; Brain - metabolism ; Choline - metabolism ; Cognition ; Cognition Disorders - diagnosis ; Cognition Disorders - metabolism ; Cognition Disorders - psychology ; Conversion to dementia ; Creatine - metabolism ; Dementia - diagnosis ; Dementia - metabolism ; Dementia - psychology ; Disease Progression ; Female ; Follow-Up Studies ; Geriatrics ; Glutamine - metabolism ; Humans ; Inositol - metabolism ; Longitudinal Studies ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Memory ; Middle Aged ; Mild cognitive impairment ; MRS ; NAA ; Parietal Lobe - metabolism ; Prognosis ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiology ; Severity of Illness Index</subject><ispartof>Psychiatry research. Neuroimaging, 2009-07, Vol.173 (1), p.1-7</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2008 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-3a829d1bcf31380900359d3929c10b877ef197b9d204a41ccdab488c7350852b3</citedby><cites>FETCH-LOGICAL-c491t-3a829d1bcf31380900359d3929c10b877ef197b9d204a41ccdab488c7350852b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pscychresns.2008.07.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21683947$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19427767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pilatus, Ulrich</creatorcontrib><creatorcontrib>Lais, Christoph</creatorcontrib><creatorcontrib>Rochmont, Anna du Mesnil de</creatorcontrib><creatorcontrib>Kratzsch, Tillmann</creatorcontrib><creatorcontrib>Frölich, Lutz</creatorcontrib><creatorcontrib>Maurer, Konrad</creatorcontrib><creatorcontrib>Zanella, Friedhelm E</creatorcontrib><creatorcontrib>Lanfermann, Heinrich</creatorcontrib><creatorcontrib>Pantel, Johannes</creatorcontrib><title>Conversion to dementia in mild cognitive impairment is associated with decline of N -actylaspartate and creatine as revealed by magnetic resonance spectroscopy</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res</addtitle><description>Abstract The purpose of the present study was to longitudinally track changes of metabolite markers detectable by magnetic resonance spectroscopy (MRS) in subjects with mild cognitive impairment (MCI) and to analyze these changes with respect to the rate of cognitive decline and clinical disease progression. Fifteen subjects with MCI and 12 healthy elderly controls were investigated longitudinally (average follow-up period: 3.4 years) using absolute quantification of metabolites within the mid-parietal grey matter and the parietal white matter [ N -acetylaspartate (NAA), myo -inositol, choline, creatine, glutamine)] Our main findings include that a longitudinal decline in cognitive function (particularly in memory function) within the MCI group was predicted by a decline in absolute concentrations of the metabolic markers NAA and creatine. This effect was mainly explained by a significant decrease of NAA and creatine in those MCI subjects who converted to Alzheimer's dementia (AD) during the follow-up period. No differences were found at baseline between MCI converters and stable subjects, indicating that at least in the present study MRS did provide a predictive discrimination between converters and stable subjects. Our findings support the use of MRS as a tool for objectively monitoring disease progression even during the earliest stages of AD.</description><subject>Aged</subject><subject>Alzheimer Disease - metabolism</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Choline - metabolism</subject><subject>Cognition</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - metabolism</subject><subject>Cognition Disorders - psychology</subject><subject>Conversion to dementia</subject><subject>Creatine - metabolism</subject><subject>Dementia - diagnosis</subject><subject>Dementia - metabolism</subject><subject>Dementia - psychology</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Geriatrics</subject><subject>Glutamine - metabolism</subject><subject>Humans</subject><subject>Inositol - metabolism</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Middle Aged</subject><subject>Mild cognitive impairment</subject><subject>MRS</subject><subject>NAA</subject><subject>Parietal Lobe - metabolism</subject><subject>Prognosis</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiology</subject><subject>Severity of Illness Index</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2O1DAQhSMEYoaBKyCzgF2asp2O4w0Sag0_0ggWwNpynMqMm8QOrnSjnIar4qhbgNjAypL9varye1UUzzhsOPD65X4zkVvcXUIKtBEAzQbUBvj2XnHJGyVKtYX6fnEJWmzLSgt1UTwi2gMI2dTyYXHBdSWUqtVl8WMXwxET-RjYHFmHI4bZW-YDG_3QMRdvg5_9EZkfJ-vT-sw8MUsUnbczduy7n--y0A0-IIs9-8BK6-ZlsDTZNGeE2ZALJbTzSlhiCY9ohyxtFzba24Czd_mSYrDBIaMJ3ZwiuTgtj4sHvR0In5zPq-LLm-vPu3flzce373evb0pXaT6X0jZCd7x1veSyAQ0gt7qTWmjHoW2Uwp5r1epOQGUr7lxn26ppnJJbaLailVfFi1PdKcVvB6TZjJ4cDoMNGA9kaiV5LWv-T1BAXQldqQzqE-jyVyhhb6bkR5sWw8GsMZq9-SNGs8ZoQJkcY9Y-PTc5tCN2v5Xn3DLw_AxYcnboUzbO0y9O8LqRpyF2Jw6zd0ePyZDzmE3ufMommy76_xrn1V9V1rB9bvwVF6R9PKSQwzHckDBgPq17t64dNAAc6lr-BG522cg</recordid><startdate>20090715</startdate><enddate>20090715</enddate><creator>Pilatus, Ulrich</creator><creator>Lais, Christoph</creator><creator>Rochmont, Anna du Mesnil de</creator><creator>Kratzsch, Tillmann</creator><creator>Frölich, Lutz</creator><creator>Maurer, Konrad</creator><creator>Zanella, Friedhelm E</creator><creator>Lanfermann, Heinrich</creator><creator>Pantel, Johannes</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20090715</creationdate><title>Conversion to dementia in mild cognitive impairment is associated with decline of N -actylaspartate and creatine as revealed by magnetic resonance spectroscopy</title><author>Pilatus, Ulrich ; Lais, Christoph ; Rochmont, Anna du Mesnil de ; Kratzsch, Tillmann ; Frölich, Lutz ; Maurer, Konrad ; Zanella, Friedhelm E ; Lanfermann, Heinrich ; Pantel, Johannes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-3a829d1bcf31380900359d3929c10b877ef197b9d204a41ccdab488c7350852b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Aged</topic><topic>Alzheimer Disease - metabolism</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Choline - metabolism</topic><topic>Cognition</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - metabolism</topic><topic>Cognition Disorders - psychology</topic><topic>Conversion to dementia</topic><topic>Creatine - metabolism</topic><topic>Dementia - diagnosis</topic><topic>Dementia - metabolism</topic><topic>Dementia - psychology</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Geriatrics</topic><topic>Glutamine - metabolism</topic><topic>Humans</topic><topic>Inositol - metabolism</topic><topic>Longitudinal Studies</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Middle Aged</topic><topic>Mild cognitive impairment</topic><topic>MRS</topic><topic>NAA</topic><topic>Parietal Lobe - metabolism</topic><topic>Prognosis</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Radiology</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pilatus, Ulrich</creatorcontrib><creatorcontrib>Lais, Christoph</creatorcontrib><creatorcontrib>Rochmont, Anna du Mesnil de</creatorcontrib><creatorcontrib>Kratzsch, Tillmann</creatorcontrib><creatorcontrib>Frölich, Lutz</creatorcontrib><creatorcontrib>Maurer, Konrad</creatorcontrib><creatorcontrib>Zanella, Friedhelm E</creatorcontrib><creatorcontrib>Lanfermann, Heinrich</creatorcontrib><creatorcontrib>Pantel, Johannes</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research. Neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pilatus, Ulrich</au><au>Lais, Christoph</au><au>Rochmont, Anna du Mesnil de</au><au>Kratzsch, Tillmann</au><au>Frölich, Lutz</au><au>Maurer, Konrad</au><au>Zanella, Friedhelm E</au><au>Lanfermann, Heinrich</au><au>Pantel, Johannes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conversion to dementia in mild cognitive impairment is associated with decline of N -actylaspartate and creatine as revealed by magnetic resonance spectroscopy</atitle><jtitle>Psychiatry research. Neuroimaging</jtitle><addtitle>Psychiatry Res</addtitle><date>2009-07-15</date><risdate>2009</risdate><volume>173</volume><issue>1</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>0925-4927</issn><eissn>1872-7506</eissn><abstract>Abstract The purpose of the present study was to longitudinally track changes of metabolite markers detectable by magnetic resonance spectroscopy (MRS) in subjects with mild cognitive impairment (MCI) and to analyze these changes with respect to the rate of cognitive decline and clinical disease progression. Fifteen subjects with MCI and 12 healthy elderly controls were investigated longitudinally (average follow-up period: 3.4 years) using absolute quantification of metabolites within the mid-parietal grey matter and the parietal white matter [ N -acetylaspartate (NAA), myo -inositol, choline, creatine, glutamine)] Our main findings include that a longitudinal decline in cognitive function (particularly in memory function) within the MCI group was predicted by a decline in absolute concentrations of the metabolic markers NAA and creatine. This effect was mainly explained by a significant decrease of NAA and creatine in those MCI subjects who converted to Alzheimer's dementia (AD) during the follow-up period. No differences were found at baseline between MCI converters and stable subjects, indicating that at least in the present study MRS did provide a predictive discrimination between converters and stable subjects. Our findings support the use of MRS as a tool for objectively monitoring disease progression even during the earliest stages of AD.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19427767</pmid><doi>10.1016/j.pscychresns.2008.07.015</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Alzheimer Disease - metabolism Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biological and medical sciences Brain - metabolism Choline - metabolism Cognition Cognition Disorders - diagnosis Cognition Disorders - metabolism Cognition Disorders - psychology Conversion to dementia Creatine - metabolism Dementia - diagnosis Dementia - metabolism Dementia - psychology Disease Progression Female Follow-Up Studies Geriatrics Glutamine - metabolism Humans Inositol - metabolism Longitudinal Studies Magnetic Resonance Spectroscopy Male Medical sciences Memory Middle Aged Mild cognitive impairment MRS NAA Parietal Lobe - metabolism Prognosis Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiology Severity of Illness Index |
| title | Conversion to dementia in mild cognitive impairment is associated with decline of N -actylaspartate and creatine as revealed by magnetic resonance spectroscopy |
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