An Ion-channel Modulator from the Saliva of the Brown Ear Tick has a Highly Modified Kunitz/BPTI Structure

Ra-KLP, a 75 amino acid protein secreted by the salivary gland of the brown ear tick Rhipicephalus appendiculatus has a sequence resembling those of Kunitz/BPTI proteins. We report the detection, purification and characterization of the function of Ra-KLP. In addition, determination of the three-dim...

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Veröffentlicht in:	Journal of molecular biology 2009-06, Vol.389 (4), p.734-747
Hauptverfasser:	Paesen, Guido C., Siebold, Christian, Dallas, Mark L., Peers, Chris, Harlos, Karl, Nuttall, Patricia A., Nunn, Miles A., Stuart, David I., Esnouf, Robert M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aprotinin - chemistry Aprotinin - classification Aprotinin - genetics Aprotinin - metabolism Cell Line Crystallography, X-Ray Dimerization Evolution, Molecular Humans Ion Channels - metabolism Ixodidae Kunitz domains maxiK channel activation Models, Molecular Molecular Sequence Data Patch-Clamp Techniques Phylogeny Protein Structure, Secondary Protein Structure, Tertiary Rhipicephalus - chemistry Rhipicephalus appendiculatus Saliva - chemistry salivary gland Sequence Alignment Sequence Homology, Amino Acid sulphur SAD
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