The Orally Active Antihyperglycemic Drug β-Guanidinopropionic Acid Is Transported by the Human Proton-Coupled Amino Acid Transporter hPAT1

The orally administered creatine analogue β-guanidinopropionic acid (β-GPA) decreases plasma glucose levels by increasing the sensitivity to insulin. This effect is based on a β-GPA induced expression of mRNA and total protein content of the insulin-responsive glucose transporter GLUT4. Although the...

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Veröffentlicht in:	Molecular pharmaceutics 2009-06, Vol.6 (3), p.1006-1011
Hauptverfasser:	Metzner, Linda, Dorn, Madlen, Markwardt, Fritz, Brandsch, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport Systems - metabolism Biological Transport - physiology Caco-2 Cells Electrophysiology Glycine - analogs & derivatives Glycine - metabolism Guanidines - chemistry Guanidines - metabolism Humans Hypolipidemic Agents - chemistry Hypolipidemic Agents - metabolism Kinetics Molecular Structure Proline - metabolism Symporters - metabolism
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