DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

The mTORC1 and mTORC2 pathways regulate cell growth, proliferation, and survival. We identify DEPTOR as an mTOR-interacting protein whose expression is negatively regulated by mTORC1 and mTORC2. Loss of DEPTOR activates S6K1, Akt, and SGK1, promotes cell growth and survival, and activates mTORC1 and...

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Veröffentlicht in:	Cell 2009-05, Vol.137 (5), p.873-886
Hauptverfasser:	Peterson, Timothy R., Laplante, Mathieu, Thoreen, Carson C., Sancak, Yasemin, Kang, Seong A., Kuehl, W. Michael, Gray, Nathanael S., Sabatini, David M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cell Survival Cyclin D1 - metabolism Cyclin D3 Cyclins - metabolism Humans HUMDISEASE Intracellular Signaling Peptides and Proteins Multiple Myeloma - metabolism Phosphatidylinositol 3-Kinases - metabolism Protein Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal Transduction SIGNALING TOR Serine-Threonine Kinases - metabolism
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