Incidence of human papilloma virus in lung cancer

Abstract HPV has been identified not only in gynaecological carcinomas but also in tumors of other organs, especially of the oropharynx and upper aero-digestive tract. In this study we focused on the available literature on HPV in lung carcinomas. In total, 53 publications reporting on 4508 cases we...

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Veröffentlicht in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2009-07, Vol.65 (1), p.13-18
Hauptverfasser: Klein, Friederike, Amin Kotb, Waleed F.M, Petersen, Iver
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container_end_page 18
container_issue 1
container_start_page 13
container_title Lung cancer (Amsterdam, Netherlands)
container_volume 65
creator Klein, Friederike
Amin Kotb, Waleed F.M
Petersen, Iver
description Abstract HPV has been identified not only in gynaecological carcinomas but also in tumors of other organs, especially of the oropharynx and upper aero-digestive tract. In this study we focused on the available literature on HPV in lung carcinomas. In total, 53 publications reporting on 4508 cases were reviewed and assessed for the following parameters: continent and region of the study, number of cases, detection method, material type, HPV type, histological subtype and number of the HPV-positive cases. Overall, the mean incidence of HPV in lung cancer was 24.5%. While in Europe and the America the average reported frequencies were 17% and 15%, respectively, the mean number of HPV in asian lung cancer samples was 35.7%. There was a considerable heterogeneity between certain countries and regions. Particular high frequencies of up to 80% were seen in Okinawa (Japan) and Taichung (Taiwan). However, there were also discrepant results within the same region pointing to methodological differences and the need for validation. All lung cancer subtypes were affected and especially the high risk types 16, 18, 31 and 33 as well as the low risk types 6 and 11 were found, the later mainly in association with squamous cell carcinomas. The data suggest that HPV is the second most important cause of lung cancer after cigarette smoking and strongly argues for additional research on this issue.
doi_str_mv 10.1016/j.lungcan.2008.10.003
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All lung cancer subtypes were affected and especially the high risk types 16, 18, 31 and 33 as well as the low risk types 6 and 11 were found, the later mainly in association with squamous cell carcinomas. 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All lung cancer subtypes were affected and especially the high risk types 16, 18, 31 and 33 as well as the low risk types 6 and 11 were found, the later mainly in association with squamous cell carcinomas. 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subjects Americas - epidemiology
Asia - epidemiology
Australia - epidemiology
Biological and medical sciences
Cancer
Epidemiology
Europe - epidemiology
Hematology, Oncology and Palliative Medicine
HPV
Humans
Incidence
ISH
Lung
Lung Neoplasms - epidemiology
Lung Neoplasms - virology
Medical sciences
Papillomaviridae - isolation & purification
Papillomavirus Infections - epidemiology
PCR
Pneumology
Pulmonary/Respiratory
Risk factor
Tumors
Tumors of the respiratory system and mediastinum
title Incidence of human papilloma virus in lung cancer
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