Comparison of morphine and tramadol effects on phagocytic activity of mice peritoneal phagocytes in vivo
It has been claimed that, in contrast to most opioids, tramadol does not suppress immune functions. We therefore, studied the effects of tramadol in comparison to morphine, on the number of phagocytes and the number of sheep red blood cells (SRBCs) engulfed by each individual cell (phagocytic index)...
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| Veröffentlicht in: | International immunopharmacology 2009-07, Vol.9 (7), p.968-970 |
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| creator | Shirzad, Hedayatollah Shahrani, Mehrdad Rafieian-Kopaei, Mahmoud |
| description | It has been claimed that, in contrast to most opioids, tramadol does not suppress immune functions. We therefore, studied the effects of tramadol in comparison to morphine, on the number of phagocytes and the number of sheep red blood cells (SRBCs) engulfed by each individual cell (phagocytic index) of mouse peritoneal phagocyte.
In an experimental study, 63 BALB/c mice received morphine, tramadol or saline intraperitoneally. On days 3, 5, and 10, the peritoneal phagocytes were incubated with an equal number of SRBCs. The cells were then cytocentrifuged onto gelatin-coated slides and examined microscopically.
Ten days after the start of drug administration, the number of phagocytes and the phagocytic index reduced in morphine group (
P
<
0.05), and enhanced in tramadol group (
P
<
0.05).
In conclusion, tramadol stimulation of immune system may offer a good alternative to morphine for the treatment of patients in whom immunosuppression might be hazardous or in patients who cannot tolerate the side effects of morphine. |
| doi_str_mv | 10.1016/j.intimp.2009.04.002 |
| format | Article |
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In an experimental study, 63 BALB/c mice received morphine, tramadol or saline intraperitoneally. On days 3, 5, and 10, the peritoneal phagocytes were incubated with an equal number of SRBCs. The cells were then cytocentrifuged onto gelatin-coated slides and examined microscopically.
Ten days after the start of drug administration, the number of phagocytes and the phagocytic index reduced in morphine group (
P
<
0.05), and enhanced in tramadol group (
P
<
0.05).
In conclusion, tramadol stimulation of immune system may offer a good alternative to morphine for the treatment of patients in whom immunosuppression might be hazardous or in patients who cannot tolerate the side effects of morphine.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2009.04.002</identifier><identifier>PMID: 19361579</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Animals ; Biological and medical sciences ; Coculture Techniques ; Erythrocytes - metabolism ; Immune response ; Immune system ; Immunosuppression ; Injections, Intraperitoneal ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - immunology ; Macrophages, Peritoneal - metabolism ; Macrophages, Peritoneal - pathology ; Male ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Microscopy ; Morphine ; Morphine - administration & dosage ; Phagocyte ; Phagocytosis ; Phagocytosis - drug effects ; Phagocytosis - immunology ; Pharmacology. Drug treatments ; Sheep ; Tramadol ; Tramadol - administration & dosage</subject><ispartof>International immunopharmacology, 2009-07, Vol.9 (7), p.968-970</ispartof><rights>2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-dad15f1fbf7bdf0d823c469ae4a01a199c3e6a41e9f5e333d4fa9d04cfe5a2573</citedby><cites>FETCH-LOGICAL-c446t-dad15f1fbf7bdf0d823c469ae4a01a199c3e6a41e9f5e333d4fa9d04cfe5a2573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1567576909001325$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21673518$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19361579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shirzad, Hedayatollah</creatorcontrib><creatorcontrib>Shahrani, Mehrdad</creatorcontrib><creatorcontrib>Rafieian-Kopaei, Mahmoud</creatorcontrib><title>Comparison of morphine and tramadol effects on phagocytic activity of mice peritoneal phagocytes in vivo</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>It has been claimed that, in contrast to most opioids, tramadol does not suppress immune functions. We therefore, studied the effects of tramadol in comparison to morphine, on the number of phagocytes and the number of sheep red blood cells (SRBCs) engulfed by each individual cell (phagocytic index) of mouse peritoneal phagocyte.
In an experimental study, 63 BALB/c mice received morphine, tramadol or saline intraperitoneally. On days 3, 5, and 10, the peritoneal phagocytes were incubated with an equal number of SRBCs. The cells were then cytocentrifuged onto gelatin-coated slides and examined microscopically.
Ten days after the start of drug administration, the number of phagocytes and the phagocytic index reduced in morphine group (
P
<
0.05), and enhanced in tramadol group (
P
<
0.05).
In conclusion, tramadol stimulation of immune system may offer a good alternative to morphine for the treatment of patients in whom immunosuppression might be hazardous or in patients who cannot tolerate the side effects of morphine.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Coculture Techniques</subject><subject>Erythrocytes - metabolism</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunosuppression</subject><subject>Injections, Intraperitoneal</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Macrophages, Peritoneal - metabolism</subject><subject>Macrophages, Peritoneal - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microscopy</subject><subject>Morphine</subject><subject>Morphine - administration & dosage</subject><subject>Phagocyte</subject><subject>Phagocytosis</subject><subject>Phagocytosis - drug effects</subject><subject>Phagocytosis - immunology</subject><subject>Pharmacology. Drug treatments</subject><subject>Sheep</subject><subject>Tramadol</subject><subject>Tramadol - administration & dosage</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-LFDEQxZtF2b9-A5Fc9NZt0p2kJxdBBnWFBS_uOdQkFSdDd9ImmYH59pt1hvWmdami-L2ieK9p3jLaMcrkx13nQ_Hz0vWUqo7yjtL-orlmq3HVspGKV3UWcmzFKNVVc5PzjtK65-yyuWJqkEyM6rrZruO8QPI5BhIdmWNatj4ggWBJSTCDjRNB59CUTCqzbOFXNMfiDQFT_MGX4x-dN0gWTL7EgDC9YJiJD-TgD_Guee1gyvjm3G-bx69ffq7v24cf376vPz-0hnNZWguWCcfcxo0b66hd9YPhUgFyoAyYUmZACZyhcgKHYbDcgbKUG4cCejEOt82H090lxd97zEXPPhucJggY91nLcWC9pOy_YLVV1uoryE-gSTHnhE4vyc-QjppR_RyF3ulTFM8apSnXNYoqe3e-v9_MaP-Kzt5X4P0ZgGxgcgmC8fmF61l9VbBV5T6dOKy2HTwmnY3HYND6VGPRNvp_f_IE3wOrrQ</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Shirzad, Hedayatollah</creator><creator>Shahrani, Mehrdad</creator><creator>Rafieian-Kopaei, Mahmoud</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20090701</creationdate><title>Comparison of morphine and tramadol effects on phagocytic activity of mice peritoneal phagocytes in vivo</title><author>Shirzad, Hedayatollah ; Shahrani, Mehrdad ; Rafieian-Kopaei, Mahmoud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-dad15f1fbf7bdf0d823c469ae4a01a199c3e6a41e9f5e333d4fa9d04cfe5a2573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Coculture Techniques</topic><topic>Erythrocytes - metabolism</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunosuppression</topic><topic>Injections, Intraperitoneal</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Macrophages, Peritoneal - metabolism</topic><topic>Macrophages, Peritoneal - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microscopy</topic><topic>Morphine</topic><topic>Morphine - administration & dosage</topic><topic>Phagocyte</topic><topic>Phagocytosis</topic><topic>Phagocytosis - drug effects</topic><topic>Phagocytosis - immunology</topic><topic>Pharmacology. Drug treatments</topic><topic>Sheep</topic><topic>Tramadol</topic><topic>Tramadol - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shirzad, Hedayatollah</creatorcontrib><creatorcontrib>Shahrani, Mehrdad</creatorcontrib><creatorcontrib>Rafieian-Kopaei, Mahmoud</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shirzad, Hedayatollah</au><au>Shahrani, Mehrdad</au><au>Rafieian-Kopaei, Mahmoud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of morphine and tramadol effects on phagocytic activity of mice peritoneal phagocytes in vivo</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>9</volume><issue>7</issue><spage>968</spage><epage>970</epage><pages>968-970</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><abstract>It has been claimed that, in contrast to most opioids, tramadol does not suppress immune functions. We therefore, studied the effects of tramadol in comparison to morphine, on the number of phagocytes and the number of sheep red blood cells (SRBCs) engulfed by each individual cell (phagocytic index) of mouse peritoneal phagocyte.
In an experimental study, 63 BALB/c mice received morphine, tramadol or saline intraperitoneally. On days 3, 5, and 10, the peritoneal phagocytes were incubated with an equal number of SRBCs. The cells were then cytocentrifuged onto gelatin-coated slides and examined microscopically.
Ten days after the start of drug administration, the number of phagocytes and the phagocytic index reduced in morphine group (
P
<
0.05), and enhanced in tramadol group (
P
<
0.05).
In conclusion, tramadol stimulation of immune system may offer a good alternative to morphine for the treatment of patients in whom immunosuppression might be hazardous or in patients who cannot tolerate the side effects of morphine.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><pmid>19361579</pmid><doi>10.1016/j.intimp.2009.04.002</doi><tpages>3</tpages></addata></record> |
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| ispartof | International immunopharmacology, 2009-07, Vol.9 (7), p.968-970 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Coculture Techniques Erythrocytes - metabolism Immune response Immune system Immunosuppression Injections, Intraperitoneal Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism Macrophages, Peritoneal - pathology Male Medical sciences Mice Mice, Inbred BALB C Microscopy Morphine Morphine - administration & dosage Phagocyte Phagocytosis Phagocytosis - drug effects Phagocytosis - immunology Pharmacology. Drug treatments Sheep Tramadol Tramadol - administration & dosage |
| title | Comparison of morphine and tramadol effects on phagocytic activity of mice peritoneal phagocytes in vivo |
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