Dipyridamole inhibits cobalt chloride-induced osteopontin expression in NRK52E cells

Osteopontin plays a pivotal role in the progression of interstitial fibrosis in renal ischemia. In the present study, rat renal tubular NRK52E cells treated with hypoxia mimetic cobalt chloride (CoCl 2) increased osteopontin production, and are associated with increased phosphorylation of Akt/PKB (p...

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Veröffentlicht in:	European journal of pharmacology 2009-06, Vol.613 (1), p.10-18
Hauptverfasser:	Chen, Tso-Hsiao, Chang, Chia-Fang, Yu, Shu-Chuan, Wang, Jiueng-Chueng, Chen, Cheng-Hsien, Chan, Paul, Lee, Horng-Mo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocatalysis Biological and medical sciences Carbon Monoxide - metabolism Cell Line Cobalt - pharmacology Dipyridamole Dipyridamole - pharmacology Enzyme Induction - drug effects Epithelial Cells - drug effects Epithelial Cells - metabolism Gene Expression Regulation - drug effects Heme - metabolism Heme oxygenase-1 Heme Oxygenase-1 - biosynthesis Kidney Tubules - cytology Medical sciences Mitogen-Activated Protein Kinase Phosphatases - metabolism NRK52E tubular cell Osteopontin Osteopontin - biosynthesis Osteopontin - metabolism Pharmacology. Drug treatments Rats Reactive Oxygen Species - metabolism
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